Accès ouvert
2025
article
OpenAlex
Wei Teng, Ting‐Tsung Chang, Chien‐Wei Su, Jie Xu et autres
OBJECTIVES: This study investigated the impact and related mechanisms of single-nucleotide variants (SNVs) in the HBV pre-S/S region on tumor development, and evaluated the role of antiviral therapy. METHODS: A retrospective analysis was conducted in 104 patients of the gray zone. HCC-associated …
tw
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Accès ouvert
2025
article
OpenAlex
Wen‐Chun Liu, Hsin‐Yu Kuo, Hung‐Wen Tsai, Yih‐Jyh Lin et autres
BACKGROUND: The human microbiome is increasingly recognized as a factor in cancer development, though its role in primary liver cancer (PLC) remains unclear. This retrospective cohort study examines tissue-specific microbiota differences between hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), and explores their association …
tw
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Accès ouvert
2025
erratum
OpenAlex
Edward Gane, Ewa Janczewska, Tetsuo Takehara, Wan‐Long Chuang et autres
[This corrects the article DOI: 10.1016/j.jhepr.2025.101516.].
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Accès ouvert
2025
article
OpenAlex
Edward Gane, Ewa Janczewska, Tetsuo Takehara, Wan‐Long Chuang et autres
Background & aims Previous studies showed combination treatment with short interfering RNA JNJ-73763989 (JNJ-3989)±capsid assembly modulator bersacapavir (JNJ-56136379) and nucleos(t)ide analogs (NAs) was well tolerated by chronic hepatitis B (CHB) patients, with JNJ-3989 dose-dependent reductions in viral markers, including hepatitis B surface …
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Accès ouvert
2025
article
OpenAlex
Hsin‐Ni Liu, Selena Y. Lin, Ricardo Ramírez, Shin‐En Chen et autres
This study characterized a hepatitis B virus (HBV) hybridization-capture next-generation sequencing (HBV-NGS) assay and applied it to develop a model for estimating the integrated HBV DNA (iDNA) quantity and for HBV genetics liquid biopsy. Using HBV monomers and reconstituted cell line DNA …
us, tw
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Accès ouvert
2025
article
OpenAlex
C. Chiang, Yih‐Jyh Lin, Wen‐Chun Liu, Ting‐Tsung Chang et autres
The posttransplantation recurrence rate of hepatitis B virus (HBV) infection in patients with chronic hepatitis B (CHB) is underestimated and linked with unfavorable outcomes. We investigated HBV recurrence by serum assays in patients with CHB following liver transplantation. We enrolled patients with …
tw
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Accès ouvert
2025
review
OpenAlex
Richard S. Finn, Kangsheng Gu, Xi Chen, Philippe Merle et autres
Background & Aims: We performed a meta-analysis of data from the KEYNOTE-240 and KEYNOTE-394 studies to obtain a more precise estimate of the pembrolizumab treatment effect in participants with previously treated advanced hepatocellular carcinoma (HCC). Methods: Participants with confirmed HCC and disease …
us, cn, fr, kr, tw, jp
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2024
conference-paper
OpenAlex
Young‐Suk Lim, Grace Wong, Sang Hoon Ahn, Wai Kay Seto et autres
Background In an integrated analysis of 2 global Phase 3 studies, we evaluated HCC incidence and risk at 8 years in patients treated with TAF and those treated initially with TDF and then switched to TAF for up to 6 years (y). …
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2024
conference-abstract
OpenAlex
Lorenza Rimassa, Daneng Li, Masafumi Ikeda, Mark Yarchoan et autres
484 Background: Combinations of a PD-1/L1 inhibitor with a CTLA-4 or VEGF inhibitor have been approved as 1L treatment options for pts with advanced HCC. The multicenter, phase 2 KEYSTEP-004 study (NCT04740307) was conducted to evaluate the coformulation of quavonlimab (CTLA-4 inhibitor) …
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Accès ouvert
2023
article
OpenAlex
Selena Y. Lin, Wei Xia, Amy K. Kim, Dion Chen et autres
An optimized hepatocellular carcinoma (HCC)-targeted methylation next generation sequencing assay was developed to discover HCC-associated methylation markers directly from urine for HCC screening. Urine cell-free DNA (ucfDNA) isolated from a discovery cohort of 31 non-HCC and 30 HCC was used for biomarker …
us, tw
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Accès ouvert
2023
article
OpenAlex
Young‐Suk Lim, Henry Lik‐Yuen Chan, Sang Hoon Ahn, Wai Kay Seto et autres
Background & Aims Antiviral therapy may attenuate the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). We aimed to explore how tenofovir alafenamide (TAF) and tenofovir disoproxil fumarate (TDF) affect HCC risk in patients with CHB. Methods The …
kr, hk, cn, gb, ca, nl, tw, jp, in, it, sg, us, nz, es
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Accès ouvert
2023
article
OpenAlex
Hsueh‐Chien Chiang, Yang-Cheng Lee, Ting‐Tsung Chang, Yih‐Jyh Lin et autres
Immune checkpoint inhibitors (ICIs) combined with multitarget tyrosine kinase inhibitors (MTKIs) exert a synergistic effect and are effective in unresectable hepatocellular carcinoma (uHCC). However, precise data regarding the real-world clinical applications of these combination therapies in uHCC are lacking. This study compared …
tw
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