Mingze Wang

Phase I dose-escalation study of tenecteplase, a third-generation fibrinolytic agent, combined with neuronavigation-assisted stereotactic minimally invasive puncture, in patients with acute spontaneous deep cerebral haemorrhage

Zhiyou Wu, Mingze Wang, Jinyi Tang, Ni Yang et autres

INTRODUCTION: Tenecteplase (TNK) offers logistical advantages in stroke thrombolytic therapy with its single bolus administration compared with alteplase. Moreover, its high specificity for fibrin may contribute to a reduction in haemorrhage complications. However, the safety, tolerability and efficacy of TNK, combined with …

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Neuronavigation-assisted stereotactic minimally invasive puncture with tenecteplase for the treatment of acute spontaneous deep intracerebral haemorrhage (NAS-TNK): rationale and design of a multicentre randomised trial

Mingze Wang, Zhiyou Wu, Jingyi Tang, Shaozhi Zhao et autres

INTRODUCTION: Minimally invasive puncture surgery followed by thrombolysis has been proven to be an effective approach for managing hypertensive intracerebral haemorrhage (ICH). Nevertheless, its impact on improving neurological outcomes remains controversial. The integration of neuronavigation-assisted stereotactic (NAS) technology will significantly help enhance …

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One-stage hybrid operation for hypervascular central nervous system tumors: a single-center experience of 31 cases

Mingze Wang, Zhikang Zhao, Shuo Wang, Yong Bao Cao et autres

BACKGROUND: Surgical resection for hypervascular central nervous system tumors poses a significant challenge for neurosurgeons. Controversy remains about the effect and safety of the traditional therapeutic mode, which combines preoperative embolization and delayed tumor resection, remain controversial. Whether a one-stage hybrid operation …

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Emergency neurosurgical hybrid operating platform for acute intracranial hemorrhage (E-HOPE)

Mingze Wang, P. T. Ge, Yuming Jiao, Xiaofeng Deng et autres

BACKGROUND: Precise diagnosis and rapid treatment for acute complex intracranial hemorrhage (ICH) are crucial. The neurosurgical hybrid operating platform integrates traditional open neurosurgery operating room functionalities with endovascular therapy capabilities and is developing in the neurosurgical practice. However, its effect on the …

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Multimodal treatments of brain arteriovenous malformations: a comparison of microsurgical timings after endovascular embolization

Chaofan Zeng, Mingze Wang, Xiaowen Song, Qingzhen Zhang et autres

Background: To compare the clinical outcomes of hybrid microsurgery and embolization with multistaged procedure for patients harboring brain arteriovenous malformations (bAVMs).Methods: We retrospectively reviewed bAVM patients from a multicenter, prospectively collected database (NCT03774017) between June 2016 and June 2020.Patients were divided into …

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Comparison of Endovascular Embolization Plus Simultaneous Microsurgical Resection vs. Primary Microsurgical Resection for High-Grade Brain Arteriovenous Malformations

Mingze Wang, Fa Lin, Hancheng Qiu, Yong Bao Cao et autres

Aim: It remains a challenge in surgical treatments of brain arteriovenous malformations (AVMs) in Spetzler-Martin Grade (SMG) IV and V to achieve both optimal neurological outcomes and complete obliteration. The authors reported a series of patients with AVMs in SMG IV and …

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Chinese Cerebrovascular Neurosurgery Society and Chinese Interventional & Hybrid Operation Society, of Chinese Stroke Association Clinical Practice Guidelines for Management of Brain Arteriovenous Malformations in Eloquent Areas

Mingze Wang, Yuming Jiao, Chaofan Zeng, Qingzhen Zhang et autres

Aim:The aim of this guideline is to present current and comprehensive recommendations for the management of brain arteriovenous malformations (bAVMs) located in eloquent areas. Methods:An extended literature search on MEDLINE was performed between Jan 1970 and May 2020. Eloquence-related literature was further …

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Clinical features and outcomes of PComA aneurysms originating from fetal posterior communicating arteries in a single institution

Xin Chen, Hao Li, Mingze Wang, Maogui Li et autres

Abstract Background The aim of this study was to retrospectively analyze our experience with the patients who underwent surgical treatment of posterior communicating artery (PComA) aneurysms originating from fetal posterior cerebral artery (fPCA) and analyze the risk factors for the postoperative radiological …

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Efficacy of Surgical Revascularizations in Young and Middle-aged Patients with Symptomatic Middle Cerebral Arterial Occlusion

Mingze Wang, Xingju Liu, Yan Zhang, Yuanli Zhao et autres

Abstract Background: Treatments on middle cerebral arterial occlusions (MCAO) remain controversial. This study aims at investigating efficacies of surgical revascularizations in young and middle-aged patients (aged 18-65 y) with symptomatic MCAO, and making comparisons between surgical procedures.Methods: From a seven-year prospective consecutive …

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Efficacy of Surgical Revascularizations in Young and Middle-aged Patients with Symptomatic Middle Cerebral Arterial Occlusion

Mingze Wang, Xingju Liu, Yong Hui Cao, Yan Zhang et autres

Abstract Background: Treatments on middle cerebral arterial occlusions (MCAO) remain controversial. This study aims at investigating efficacies of surgical revascularizations in young and middle-aged patients (aged 18-65 y) with symptomatic MCAO, and making comparisons between surgical procedures.Methods: From a seven-year prospective consecutive …

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Clinical characteristics and risk factors of perioperative outcomes in elderly patients with intracranial tumors

Xiaowen Song, Chaofan Zeng, Mingze Wang, Wen Wang et autres

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One-staged in situ embolization combined with surgical resection for eloquence protection of AVM: technical note

Mingze Wang, Hancheng Qiu, Yong Bao Cao, Shuo Wang et autres

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