Lesley C. Kaye

Responsive stimulation of the thalamus for idiopathic generalized epilepsy: Results of the randomized controlled NAUTILUS trial through 18 months

Utku Uysal, Patrick Landazuri, David E. Burdette, Sanjay Patra et autres

OBJECTIVE: This study was undertaken to evaluate the safety and effectiveness of responsive thalamic stimulation as adjunctive therapy for drug-resistant idiopathic generalized epilepsy (IGE) with generalized tonic-clonic seizures (GTCSs). METHODS: NAUTILUS is a prospective, multicenter, single-blind, randomized sham-controlled pivotal trial. Patients were …

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Postapproval Study for Brain-Responsive Neurostimulation for Drug-Resistant Focal Epilepsy

Dawn Eliashiv, Vikram R. Rao, Barbara C. Jobst, Jerzy P. Szaflarski et autres

BACKGROUND AND OBJECTIVES: Neuromodulation therapies are approved for the treatment of focal epilepsy based on data from randomized controlled trials (RCTs). After approval of a responsive direct brain stimulation device (The RNS System for focal epilepsy), the Food and Drug Administration required …

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Feasibility study of microburst VNS therapy in drug-resistant focal and generalized epilepsy

Cornelia Natasha Drees, Pegah Afra, Ryan S. Verner, Lesley C. Kaye et autres

BACKGROUND: Vagus nerve stimulation (VNS) at low frequencies (≤30 Hz) has been an established treatment for drug-resistant epilepsy (DRE) for over 25 years. OBJECTIVE: To examine the initial safety and efficacy performance of an investigational, high-frequency (≥250 Hz) VNS paradigm herein called …

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Microburst Vagus Nerve Stimulation: Safety and Efficacy Outcomes (S44.003)

Cornelia Natasha Drees, Mesha‐Gay Brown, Danielle McDermott, Lesley C. Kaye et autres

We assessed the clinical impact of Microburst-VNS in an early feasibility study.

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Clinical factors associated with late seizure remission after failed epilepsy surgery

Lesley C. Kaye, Zoe A. Poolos, John W. Miller, Nicholas P. Poolos

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