Wuping Sun

PACAP Alleviates Paclitaxel‐Induced Peripheral Neuropathy by Targeting Oxidative Stress and Mitochondrial Damage via the PGC‐1α Pathway

Ruyue Mo, Chuanming Wang, Haibei Hu, Shuqi Shi et autres

BACKGROUND: Paclitaxel-induced peripheral neuropathy (PIPN) is a severe and dose-limiting side effect. This study investigated the therapeutic potential of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and its underlying mechanism. METHODS: A murine PIPN model was established. Behavioral tests assessed neuropathic pain. Molecular and …

cn (code pays fourni par la source)

Tmem45b modulates itch via endoplasmic reticulum calcium regulation

Sashuang Wang, Liang Chen, Ruolin Wang, Zelin Sun et autres

Objective: This study aimed to investigate the role of Tmem45b, a gene expressed in itch-associated Dorsal root ganglion (DRG) neurons, in the regulation of itch sensation. Methods: conditional knockout (cKO) mice. Chronic itch was evaluated using both atopic dermatitis-like and dry skin-like …

cn (code pays fourni par la source)

Decoding Bone Cancer Pain: Pathological Mechanisms and Targeted Interventions

Mingzhu Zhai, Wuping Sun

Abstract Bone cancer pain (BCP) is one of the most prominent and disabling symptoms in patients with primary bone malignancies (e.g. osteosarcoma, Ewing’s sarcoma) and metastatic bone tumors (e.g. multiple myeloma), severely impacting quality of life and treatment efficacy. Conventional analgesic approaches …

cn (code pays fourni par la source)

Chikungunya fever: pathogenesis and mechanisms underlying pain symptoms

Wuping Sun, Shuo Shi, Shengyun Liao, Mingzhu Zhai

Chikungunya fever (CHIKF), caused by the Chikungunya virus (CHIKV) and transmitted by Aedes mosquitoes, has rapidly evolved from localized outbreaks to a significant global health threat. While the initial high fever is often debilitating, it is the severe and frequently long-lasting pain, …

cn (code pays fourni par la source)

Mitochondrial Disruption in Viral‐Mediated Neuronal Injury: A Mechanistic Perspective

Shuo Shi, Mingzhu Zhai, Benqing Wu, Wuping Sun

Neuronal injury is a major pathological issue that cannot be ignored during viral infections. Mitochondria, the energy factories of the cell, play a unique role in this scenario and are severely impacted when viruses infect host cells. Viruses invade and infect cells …

cn (code pays fourni par la source)

Cavidine alleviates paclitaxel-induced peripheral neuropathy by promoting mitochondrial autophagy through inhibiting PKM2-mediated histone lactylation

Zhenhui Luo, Zicen Fang, Xiaomin Cheng, Shuo Shi et autres

cn (code pays fourni par la source)

Single-nucleus rna sequencing identifies universal camk1d upregulation and dysregulated c-ltmr subtypes as key drivers of paclitaxel-induced neuropathy

Wuping Sun, Rongzhen Li, Xinyi Zhang, Songbin Wu et autres

Neuropathic pain triggered by chemotherapy poses a significant clinical challenge. Investigating cell type-specific alterations through single-cell transcriptome analysis holds promise in understanding symptom development and pathogenesis. In this study, we performed single nuclei RNA (snRNA) sequencing of dorsal root ganglions (DRG) to …

cn, hk (code pays fourni par la source)

The Application of HSV-1 in Investigating Neurological Diseases

Zeyi Huang, Peng Li, Chunfu Zheng, Wuping Sun

cn, ca (code pays fourni par la source)

Roseburia intestinalis-derived butyrate alleviates neuropathic pain

Yanjun Jiang, Ziheng Huang, Wuping Sun, Jiabin Huang et autres

Approximately 20% of patients with shingles develop postherpetic neuralgia (PHN). We investigated the role of gut microbiota in shingle- and PHN-related pain. Patients with shingles or PHN exhibited significant alterations in their gut microbiota with microbial markers predicting PHN development among patients …

hk, cn (code pays fourni par la source)

An analysis of the global burden of gallbladder and biliary tract cancer attributable to high BMI in 204 countries and territories: 1990–2021

Zhiping Hu, Xue Wang, Xin Zhang, Wuping Sun et autres

Background: Gallbladder and biliary tract cancers (GBTCs) are aggressive with poor prognosis, often undetected until advanced stages. High Body Mass Index (BMI) is a significant risk factor, contributing substantially to GBTC mortality and Disability-Adjusted Life Years (DALYs). This study aimed to quantify …

cn (code pays fourni par la source)

Deciphering the cellular and molecular landscapes of Wnt/β-catenin signaling in mouse embryonic kidney development

Hui Zhao, Hui Gong, Peide Zhu, Chang Sun et autres

Abstract Background The Wnt/β-catenin signaling pathway is critical in kidney development, yet its specific effects on gene expression in different embryonic kidney cell types are not fully understood. Methods Wnt/β-catenin signaling was activated in mouse E12.5 kidneys in vitro using CHIR99021, with …

cn (code pays fourni par la source)

Identification and characterization of Varicella Zoster Virus circular RNA in lytic infection

Shaomin Yang, Di Cao, Dabbu Kumar Jaijyan, Mei Wang et autres

Abstract This study investigates the role of circular RNAs (circRNAs) in the context of Varicella-Zoster Virus (VZV) lytic infection. We employ two sequencing technologies, short-read sequencing and long-read sequencing, following RNase R treatment on VZV-infected neuroblastoma cells to identify and characterize both …

hk, cn, us (code pays fourni par la source)