Renato de Falco

Study protocol on quality of life and erectile function recovery in unfavorable intermediate-risk prostate cancer: REDI-CaP trial

Rossella Di Franco, Simona Mercogliano, Rocco Mottareale, Valentina Borzillo et autres

In unfavorable intermediate-risk prostate cancer, radiotherapy plus androgen deprivation therapy (ADT) is standard, but GnRH agonists can cause testosterone flare and delayed hormonal recovery, negatively affecting erectile function (EF) and quality of life (QoL). Relugolix, an oral GnRH antagonist, enables rapid testosterone …

Study protocol on quality of life and erectile function recovery in unfavorable intermediate-risk prostate cancer: REDI-CaP trial

Rossella Di Franco, Simona Mercogliano, Rocco Mottareale, Valentina Borzillo et autres

In unfavorable intermediate-risk prostate cancer, radiotherapy plus androgen deprivation therapy (ADT) is standard, but GnRH agonists can cause testosterone flare and delayed hormonal recovery, negatively affecting erectile function (EF) and quality of life (QoL). Relugolix, an oral GnRH antagonist, enables rapid testosterone …

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Study protocol on quality of life and erectile function recovery in unfavorable intermediate-risk prostate cancer: REDI-CaP trial

Rossella Di Franco, Simona Mercogliano, Rocco Mottareale, Valentina Borzillo et autres

In unfavorable intermediate-risk prostate cancer, radiotherapy plus androgen deprivation therapy (ADT) is standard, but GnRH agonists can cause testosterone flare and delayed hormonal recovery, negatively affecting erectile function (EF) and quality of life (QoL). Relugolix, an oral GnRH antagonist, enables rapid testosterone …

Parotid Metastases from Head–Neck Cutaneous Squamous Cell Carcinoma: A Prognostic Stratification

Giulia Togo, Luca Calabrese, Giovanni Dell’Aversana Orabona, Franco Ionna et autres

BACKGROUND/OBJECTIVES: Cutaneous squamous cell carcinomas (cSCC) of the head and neck district are among the most common non melanocytic malignant skin carcinomas. The proposal to differentiate, within the N stage, parotid metastases from lateral cervical metastases, originates from the different prognostic value …

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Healthful and Unhealthful Plant-Based Diets and Their Association with Cardiometabolic Targets in Women Diagnosed with Breast Cancer: A Cross-Sectional Analysis of a Lifestyle Trial

Sara Vitale, Elvira Palumbo, Angela D’Angelo, Matteo Di Maso et autres

BACKGROUND: Plant-based diets are recommended in guidelines for the prevention of cancer and cardiometabolic diseases, which remain major causes of death in breast cancer survivors (BCS). Since not all plant foods are healthy, we calculated the plant-based dietary index (PDI), healthy (hPDI) …

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Vitamin D Supplementation and Testosterone Levels in Breast Cancer Survivors

Anita Minopoli, Piergiacomo Di Gennaro, Giuseppe Porciello, Elvira Palumbo et autres

Vitamin D plays a key role in immune modulation, cell proliferation, and hormone regulation. Dysregulated testosterone may contribute to breast cancer progression. We investigated whether long-term vitamin D supplementation affects serum testosterone levels in breast cancer survivors. Complete data at baseline, 12, …

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Assessing Urinary Para-Hydroxyphenylacetic Acid as a Biomarker Candidate in Neuroendocrine Neoplasms

Renato de Falco, Susan Costantini, Luigi Russo, Denise Giannascoli et autres

The management of neuroendocrine neoplasms (NENs) involves the measurement of serum chromogranin A (s-CGA), serum neuro-specific enolase (s-NSE), and urinary 5-hydroxindolacetic acid (5-HIAA). Urinary para-hydroxyphenylacetic acid (u-pHPAA), a metabolite of tyrosine, has been proposed as a potential biomarker for these diseases. This …

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Prevalence and distribution of M-proteins in the oncologic population affected by solid tumor

Renato de Falco, Giulia Togo, Anita Minopoli, Marco Cuomo et autres

Monoclonal Gammopathies (MG) are characterized by the proliferation of monoclonal plasma cells in the bone marrow with abnormal secretion of monoclonal immunoglobulins (M-proteins). MG include malignant disorders, such as Multiple Myeloma and Waldenström Macroglobulinemia and premalignant conditions, such as Smoldering Multiple Myeloma …

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Evaluation of Antioxidant Defence Systems and Inflammatory Status in Basketball Elite Athletes

Alessandro Gentile, Carolina Punziano, Mariella Calvanese, Renato de Falco et autres

Intense physical activity can induce metabolic changes that modify specific biochemical biomarkers. In this scenario, the purpose of our study was to evaluate how intense physical activity can affect oxidative metabolism. Following this, fifteen professional basketball players and fifteen sedentary controls were …

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B-Type Natriuretic Peptides and High-Sensitive Troponin I as COVID-19 Survival Factors: Which One Is the Best Performer?

Renato de Falco, Maria Vargas, Daniela De Palma, Marcella Savoia et autres

Increased concentrations of B-type natriuretic peptide (BNP), N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponin I (HsTnI) in COVID-19 patients have already been reported. The aim of this study is to evaluate which of these common markers of cardiac disease is the …

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Urinary Biomarkers: Diagnostic Tools for Monitoring Athletes’ Health Status

Raffaela Pero, Mariarita Brancaccio, Cristina Mennitti, Luca Gentile et autres

Acute or intense exercise is sometimes related to infections of the urinary tract. It can also lead to incorrect hydration as well as incorrect glomerular filtration due to the presence of high-molecular-weight proteins that cause damage to the kidneys. In this context, …

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Lipid profile and genetic status in a familial hypercholesterolemia pediatric population: exploring the LDL/HDL ratio

Maria Donata Di Taranto, Renato de Falco, Ornella Guardamagna, Giulia Massini et autres

Background Familial hypercholesterolemia (FH) is a genetic disorder caused by mutations in genes involved in low-density lipoprotein (LDL) uptake (LDLR, APOB and PCSK9). Genetic diagnosis is particularly useful in asymptomatic children allowing for the detection of definite FH patients. Furthermore, defining their …

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