Adam Robinson

Add-On Treatment With Zilebesiran for Inadequately Controlled Hypertension

Akshay S. Desai, Adam Karns, Jolita Badarienė, Ahmad Aswad et autres

Importance: In prior monotherapy studies of patients with hypertension, single subcutaneous doses of zilebesiran, an investigational RNA interference therapeutic, reduced serum angiotensinogen levels and systolic blood pressure (SBP) at 3 and 6 months. Objective: To evaluate the efficacy and safety of zilebesiran …

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RNA Interference With Zilebesiran for Mild to Moderate Hypertension

George L. Bakris, Manish Saxena, Anil Gupta, Fadi Chalhoub et autres

Importance: Angiotensinogen is the most upstream precursor of the renin-angiotensin-aldosterone system, a key pathway in blood pressure (BP) regulation. Zilebesiran, an investigational RNA interference therapeutic, targets hepatic angiotensinogen synthesis. Objective: To evaluate antihypertensive efficacy and safety of different zilebesiran dosing regimens. Design, …

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Using Fact Data to Predict Preference-Based Utility Measures For People With Malignant Melanoma: A Review of The Evidence

Roberta Ara, Suzy Paisley, Adam Robinson, Ahmed Azough et autres

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Localization and Delocalization in a Mixed-Valence Dicopper Helicate

John C. Jeffery, T. Riis‐Johannessen, Callum J. Anderson, Christopher J. Adams et autres

The coordination chemistry of the tetradentate pyridyl-thiazole (py-tz) N-donor ligand 6,6'-bis(4-phenylthiazol-2-yl)-2,2'-bipyridine (L1) has been investigated. Reaction of L1 with equimolar copper(II) ions results in the formation of the single-stranded mononuclear complex [Cu(L1)(ClO4)2] (1), whereas reaction with copper(I) ions results in the double-stranded …

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