Anne Searls De Groot

Reduced T cell epitope cross-conservation and immunogenic potential is associated with emergence of a dominant influenza subclade K in 2025

Andres Hazaet Gutierrez, Jacob Tivin, Benjamin Gabriel, Anne Searls De Groot

Subclade K is a newly emergent influenza A/H3N2 strain that became the dominant strain circulating globally; more than 90% of influenza A virus (IAV) cases in 2025-26 were subclade K. While seasonal vaccines elicited measurable cross-reactive hemagglutination inhibition (HI) and neutralizing antibody …

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HLA Class II Alleles DRB1*11:01 and DQB1*03:01 Unmask Immunogenetic Susceptibility to Anti-Nivolumab Antibodies in Combination with Ipilimumab

Surendran Rajendran, Andres H. Gutierrez, Ming‐Shan Chien, Tracy Tang et autres

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In Silico Hypersensitivity Risk Assessment of Product-Specific Human Contaminant Proteins in Commercial IVIg Products

Ben Gabriel, Kevin Van Cott, Anne Searls De Groot

Background Intravenous immunoglobulin (IVIg) products are widely used to treat immune deficiency and autoimmune disorders; however, infusion-related reactions remain a significant clinical concern. Differences in tolerability among commercial Ig products may be associated with variability in the number and types of human …

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Proceedings of the 2024 FDA-CRCG Workshop: Scientific and Regulatory Considerations for Assessment of Immunogenicity Risk for Generic Peptide and Oligonucleotide Drug Products

Jennifer Lee, Ha-Na Lee, Sudhir Agrawal, Joseph A. Balsamo et autres

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Oportuna Vacuna: A Prospective Study of Vaccine Confidence and Vaccine Uptake in a Low-Income, Spanish-Speaking Rhode Island Population in the Post-Pandemic Era

Julia Testa, Morgan Leonard, C Wang, Sharon Farrar et autres

Background: Clínica Esperanza/Hope Clinic (CEHC), a free clinic for low-income, uninsured, Spanish-speaking patients, located in Providence, RI, piloted an intervention to improve vaccination rates. This program, named “Oportuna Vacuna” (OV) aimed to assess vaccine hesitancy in the post-pandemic period and measure improvements …

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Immunogenicity risk assessment of peptide-related impurities identified in generic teriparatide products

Aimee E. Mattei, Brian Roberts, Sandra Lélias, Shah Jahan Miah et autres

Teriparatide is one of several generic peptides named in a recent Food and Drug Administration (FDA) guidance (FDA-2017-D-5767-0002), which outlines a potential strategy to inform immunogenicity risk assessment for synthetic generic peptides without requiring clinical studies. Specifically, the guidance states that for …

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Oportuna Vacuna: A Prospective Study of Vaccine Confidence and Vaccine Uptake in a Low-Income, Spanish-Speaking Rhode Island Population in the Post-Pandemic Era

Julia Testa, Morgan Leonard, C Wang, Sharon Farrer et autres

Background: Clínica Esperanza/Hope Clinic (CEHC), a free clinic for low-income, uninsured, Spanish-speaking patients located in Providence RI, piloted an intervention to improve vaccination rates. This program, named “Oportuna Vacuna” (OV) aimed to assess vaccine hesitancy in the post-pandemic period and measure improvements …

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Establishment of Immune Biobank for Vaccine Immunogenicity Prediction Using In Vitro and In Silico Methods Against Porcine Reproductive and Respiratory Syndrome Virus

Chaitawat Sirisereewan, John Joseph Byrne, Lanre Sulaiman, Abigail Williams et autres

BACKGROUND/OBJECTIVES: Porcine reproductive and respiratory syndrome virus (PRRSV) remains one of the most economically significant pathogens in the global swine industry. Despite the availability of commercial vaccines for over three decades, they fail to induce sterile immunity and often provide inconsistent protection …

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Establishment of Immune Biobank for Vaccine Immunogenicity Prediction Using In Vitro and In Silico Methods Against Porcine Reproductive and Respiratory Syndrome Virus

Chaitawat Sirisereewan, John Joseph Byrne, Lanre Sulaiman, Abigail Williams et autres

Background/Objectives: Porcine reproductive and respiratory syndrome virus (PRRSV) remains one of the most economically significant pathogens in the global swine industry. Despite the availability of commercial vaccines for over three decades, they fail to induce sterile immunity and often provide inconsistent protection …

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Coordinating rural healthcare to support whole families caring for children with medical complexity

Anne Searls De Groot, Karen A. Hutchinson, Raghu Lingam, Jeffrey Fletcher et autres

Background: Accessing healthcare for children with medical complexity (CMC) living outside of major cities is often time-consuming and challenging to navigate, impacting quality of life and wellbeing of multiple family members caring for CMC and influencing how the whole family functions. Approach: …

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A method for identifying neoantigens through isolation of circulating tumor cells using apheresis among patients with advanced-stage cancer

Daiki Kobayashi, Takuya Kosumi, Queenie Lai Kwan Lam, Shigeharu Fujita et autres

Background Immune checkpoint inhibitors show limited efficacy in tumors with low tumor mutational burden, partly due to insufficient neoantigen presentation. Methods We developed a novel approach for neoantigen identification using circulating tumor cells (CTCs) isolated via leukapheresis and flow cytometry. Peripheral blood …

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T cell epitope content comparison using EpiCC correlates with vaccine efficacy against heterologous porcine reproductive and respiratory syndrome virus type 2 strains

James Mark Hammer, Andres Hazaet Gutierrez, Lucas Huntimer, Benjamin Gabriel et autres

Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most ubiquitous RNA viruses affecting pigs and pig farms globally. While vaccines are available, they are not entirely effective, and the introduction of modified live virus vaccines (MLV) has contributed to …

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