Hidekatsu Fukuta

NT-proBNP changes and clinical outcomes in contemporary heart failure trials: A trial-level meta-regression analysis

Hidekatsu Fukuta, Toshihiko Goto

Association between treatment-induced changes in the Kansas City Cardiomyopathy Questionnaire and clinical outcomes in chronic heart failure: a trial-level meta-regression analysis

Hidekatsu Fukuta, Toshihiko Goto

Patient-reported outcomes such as the Kansas City Cardiomyopathy Questionnaire (KCCQ) are increasingly recognized for their prognostic value. While the composite endpoint of cardiovascular death and heart failure (HF) hospitalization is the standard primary outcome in contemporary HF trials, the potential for KCCQ …

jp (code pays fourni par la source)

Colonic transit study in patients with chronic constipation using Japanese-made radiopaque markers

Takeshi KAMIYA, Eiji Kubota, Keiji Ozeki, Mamoru TANAKA et autres

A Colonic transit study (CTS) is useful and necessary for understanding the pathophysiology of disease that present with colonic motility dysfunction such as chronic constipation (CC). CTSs using radiopaque markers are a simple, safe, inexpensive, and easy to perform. However, no radiopaque …

jp (code pays fourni par la source)

Sharing Our Experience with Our First Post-COVID‒19 Pandemic FDA GCP Inspection

Akiko HATTORI-SHIME, Keiji Ozeki, Hidekatsu Fukuta, Takeshi Kamiya

jp (code pays fourni par la source)

Effects of hypoxia-inducible factor prolyl hydroxylase inhibitors on hemoglobin, B-type natriuretic peptide, and renal function in anemic heart failure patients: A systematic review and meta-analysis

Hidekatsu Fukuta, Toshihiko Goto, Takeshi Kamiya

Anemia is a common comorbidity in heart failure (HF) patients, often leading to worsened outcomes. Hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitors represent a novel approach for anemia management, yet their efficacy and safety in HF patients remain unclear. We aimed to conduct …

jp (code pays fourni par la source)

Cardiac Presynaptic Sympathetic Nervous Function Evaluated by Cardiac PET in Patients with Chronotropic Incompetence Without Heart Failure

Toshihiko Goto, Shohei Kikuchi, Yomei Sakurai, Yoshiro Tsuruta et autres

Chronotropic incompetence (CTI), the inability of the heart to increase its rate with increased activity, leads to exercise intolerance and predicts overall mortality. We previously reported that cardiac β-adrenergic receptor downregulation occurs in patients with CTI without heart failure (HF), indicating postsynaptic …

jp (code pays fourni par la source)

Effects of hypoxia-inducible factor prolyl hydroxylase inhibitors in anemic heart failure patients: a protocol for systematic review and meta-analysis

Hidekatsu Fukuta, Toshihiko Goto, Takeshi Kamiya

Sensitivity analysisMeta-regression will be used to determine whether the effect of HIF-PH inhibitors will be confounded by baseline clinical characteristics.

ru (code pays fourni par la source)

Effects of calcium channel blockers in patients with heart failure with preserved and mildly reduced ejection fraction: A systematic review and meta-analysis

Hidekatsu Fukuta, Toshihiko Goto, Takeshi Kamiya

In contrast to beta-blockers and renin-angiotensin system inhibitors, the role of calcium channel blockers (CCBs) in patients with heart failure with preserved ejection fraction (HFpEF) remains uncertain. Despite several randomized controlled trials (RCTs) and cohort studies exploring the effects of CCBs on …

jp (code pays fourni par la source)

Effects of calcium channel blockers in patients with heart failure with preserved ejection fraction: A protocol for systematic review and meta-analysis

Hidekatsu Fukuta, Toshihiko Goto, Takeshi Kamiya

BACKGROUND: Nearly half of patients with heart failure (HF) have preserved ejection fraction (EF) and the mortality and morbidity of patients with HF with preserved EF (HFpEF) are high. Patients with HFpEF are often elderly and their primary chronic symptom is severe …

jp (code pays fourni par la source)

Association of epicardial fat with cardiac structure and function and exercise capacity in heart failure with preserved ejection fraction: A systematic review and meta-analysis

Hidekatsu Fukuta, Toshihiko Goto, Takeshi Kamiya

Studies have reported the association of epicardial adipose tissue (EAT) with cardiac structure and function as well as exercise capacity in patients with heart failure with preserved ejection fraction (HFpEF), yielding inconsistent results. We aimed to conduct a meta-analysis of studies on …

jp (code pays fourni par la source)

Effects of calcium channel blockers in patients with heart failure with preserved ejection fraction: a protocol for systematic review and meta-analysis

Hidekatsu Fukuta, Toshihiko Goto, Takeshi Kamiya

Condition being studied Heart failure with preserved ejection fraction (HFpEF). METHODSParticipant or population Patients with HFpEF. Intervention Calcium channel blockers (CCBs).Comparator Placebo or standard therapy.

jp, ru (code pays fourni par la source)

Association of epicardial fat with cardiac structure and function and exercise capacity in heart failure with preserved ejection fraction: a protocol for systematic review and meta-analysis

Hidekatsu Fukuta, Toshihiko Goto, Takeshi Kamiya

Sensitivity analysisMeta-regression will be used to determine whether the association of increased epicardial fat with outcomes will be confounded by baseline clinical characteristics. Country(ies) involved Japan.

jp (code pays fourni par la source)