Piers Klein

Role of Thrombectomy Technique in Alteplase Bridging Intravenous Thrombolysis for Basilar Artery Occlusion

Muhammad Jaffar, Kazi Ahmed, Samir Abu‐Rumeileh, Markus Otto et autres

Background Endovascular treatment (EVT) is the standard of care for acute basilar artery occlusion (BAO) although the role of bridging intravenous thrombolysis (IVT) with alteplase prior to EVT remains debated. Whether the effect of bridging IVT differs across EVT techniques has not …

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Racial disparities in off-guideline endovascular treatments for acute ischaemic stroke

Jacklyn Samaha, Ngoc Mai Le, Ananya Iyyangar, Eunyoung Lee et autres

Introduction Endovascular thrombectomy (EVT) is an established treatment for large vessel occlusion acute ischaemic stroke, and indications have expanded to include broader patient groups. Whether this expansion has occurred equitably across racial and ethnic populations remains unclear. Materials/methods We analysed the SVIN …

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Role of Perfusion Parameters on Outcomes and Safety of Endovascular Therapy in Posterior Cerebral Artery Stroke

Norma J. Diel, Davide Strambo, Mohamad Abdalkader, Muhammad M. Qureshi et autres

BACKGROUND: The optimal management of isolated posterior cerebral artery occlusion (iPCAO) remains unclear. We investigated whether baseline perfusion imaging parameters are associated with clinical outcomes and whether they modify the association between endovascular therapy (EVT) and outcomes in iPCAO. METHODS: This prespecified …

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MAD-MT Score: A Tool to Optimize Patient Selection for Mechanical Thrombectomy in Distal Vessel Occlusions

Huanwen Chen, Dhairya A. Lakhani, Hamza Salim, Marco Colasurdo et autres

BACKGROUND: Endovascular thrombectomy (EVT) for distal and medium vessel occlusion stroke remains uncertain. We aimed to develop a medium and distal mechanical thrombectomy score integrating clinical need and procedural risk to guide patient selection. METHODS: This retrospective cohort analysis used an international …

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Intracranial Stenting During Acute Endovascular Therapy of Stroke: Clinical and Radiological Outcomes of the RESISTANT International Registry

Manuel Requena, Marta Olivé‐Gadea, Francesco Diana, Johannes Kaesmacher et autres

BACKGROUND: In the case of failed reperfusion or severe stenosis during endovascular treatment of acute stroke, intracranial stenting is a growing practice. We aimed to study clinical and radiological outcomes in a large multicenter cohort. METHODS: The RESISTANT registry (Registry of Endovascular …

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Intravenous Thrombolysis in Distal Medium Middle Cerebral Artery Occlusion Patients with Unsuccessful Mechanical Reperfusion

Hamza Salim, Benjamin Pulli, Vivek Yedavalli, Dhairya A. Lakhani et autres

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Safety and efficacy of intravenous thrombolytics among patients with emergent intracranial stenting after thrombectomy: Subanalysis of the RESISTANT registry

Adnan Mujanović, Marta Olivé‐Gadea, Francesco Diana, Greta Sökeland et autres

BACKGROUND: The value of intravenous thrombolysis (IVT) prior to endovascular therapy (EVT) with emergent stenting for intracranial atherosclerotic disease (ICAD)-large vessel occlusion (LVO) is unknown. We aimed to investigate the safety and efficacy of IVT among patients with adjuvant intracranial stenting after …

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Outcomes of Witnessed Versus Unwitnessed Patients With Stroke After Endovascular Therapy in the Extended Time Window

Liisa Tomppo, Nicolas Martinez‐Majander, Muhammad M. Qureshi, Thanh N. Nguyen et autres

BACKGROUND: It remains unclear whether outcomes of patients treated with endovascular thrombectomy with large-vessel occlusion and unwitnessed onset of stroke differ from those with witnessed onset in the extended time window. METHODS: We enrolled patients with anterior circulation large-vessel occlusion (internal carotid …

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Prevalence and Radiologic Manifestations of Internal Jugular Venous Stenosis in Patients with Pulsatile Tinnitus: A Case-Control Study

Zhongyuan Zhang, Piers Klein, Bindu N. Setty, Pamela Semaan et autres

ABSTRACT BACKGROUND AND PURPOSE: The role of internal jugular venous stenosis (IJVS) in the development of pulsatile tinnitus (PT) is unclear. In this study, we aim to assess the prevalence of IJVS and to analyze the associated imaging findings in patients with …

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Fibromuscular Dysplasia and Spontaneous Cervical Artery Dissection

Ahmad Nehme, Liqi Shu, Marion Boulanger, Junpeng Ma et autres

Importance: Fibromuscular dysplasia (FMD) is found in 6 to 14% of patients with spontaneous cervical artery dissection (SCEAD) and may be associated with recurrent SCEAD. Objective: To evaluate the correlates of FMD in patients with SCEAD and to determine whether FMD is …

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Impaired Perfusion and Early Ischemic Stroke Recurrence in Symptomatic Intracranial Atherosclerosis: BIORISK ICAS Study

Shadi Yaghi, Farhan Khan, Skylar Lewis, Ava Stipanovich et autres

BACKGROUND: Intracranial atherosclerosis (ICAS) is associated with an increased risk of early recurrent ischemic stroke. We evaluated whether biomarkers of impaired distal perfusion—specifically, anterior circulation borderzone infarct, and hypoperfusion mismatch volume—were associated with recurrent ischemic stroke within 90 days. METHODS: The BIORISK …

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Factors associated with early neurological deterioration in minor distal medium vessel acute ischemic stroke: A multinational multicenter study

Dhairya A. Lakhani, Hamza Salim, Vivek Yedavalli, Basel Musmar et autres

Background: Patients with acute ischemic stroke secondary to distal and medium vessel occlusion (AIS-DMVO) and minor strokes present a challenge in determining the most appropriate emergent treatment. Factors leading to early neurological deterioration (END) in this patient population are understudied, but END …

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