Daniel Amsterdam

Evaluating Bacterial-Antimicrobial Agent Interactions In The Laboratory To Understand The Challenge of Resistance

Daniel Amsterdam

In this overview, multiple laboratory interactions of antimicrobial agents and bacteria used to define resistance are described.The ability to demonstrate antimicrobial resistance through standard and innovative laboratory techniques is characterized Using innovative techniques in the microbiology laboratory.Potential resistance to bacteriophage therapy, previously …

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Confronting Accelerating Global Antimicrobial Resistance and the Associated Increase in Deaths

Daniel Amsterdam

Although advances in contemporary medical care have broadened access to healthcare and extended the human life span, deaths resulting from antimicrobial-resistant pathogens continue to increase. This minireview summarizes the evidence that AI and machine learning, coupled with precision medicine and alternative therapies, …

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Perspective: Limiting Antimicrobial Resistance with Artificial Intelligence/Machine Learning

Daniel Amsterdam

The author traces his experience with the application of computers in clinical microbiology over the past 60 years, specifically in directing clinicians to treat bacterial infections diagnosed by the laboratory and the antibacterial agent(s) that could be used to treat those infections. …

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Immunological Investigations Thematic: Editors’ Introduction

Barbara E. Ostrov, Daniel Amsterdam

This year’s Thematic was created in the crucible of the COVID-19 pandemic. March 2021 marked the one-year anniversary of world-wide recognition of the impact of COVID-19. Lessons from years combatt...

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Recalibration of the Antimicrobial MIC

Daniel Amsterdam

In 2009, the World health organization (WHO) referred to the problem of antibiotics and antibiotic resistance stating, “Antibiotic Resistance – one of the three greatest threats to human health.” In 2019 (i.e., just as the COVID-19 pandemic was evolving), more than 2.8 …

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Interplay of Anti-Viral Vaccines with Biologic Agents and Immunomodulators in Individuals with Autoimmune and Autoinflammatory Diseases

Barbara E. Ostrov, Daniel Amsterdam

Vaccines are an essential part of a preventative healthcare strategy. However, response to vaccines may be less predictable in immunocompromised people. While outcomes for individuals with autoimmune and autoinflammatory diseases have dramatically improved with treatment using immunomodulating and biologic agents, infections have …

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Limitations of Immunotherapeutic Approaches for Cancer Treatment

Daniel Amsterdam

Of the multiple approaches to cancer therapy, few are as complex as those regimens that encompass immune-based agents. Immunotherapeutic approaches have been the central focus of medical investigators for the past several years.

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The Impact of the Microbiome on Immunosenescence

Daniel Amsterdam, Barbara E. Ostrov

Human microbiome investigations now provide evidence that changes in the microbiome over time and their interaction with the immune, endocrine, and nervous systems are associated with a wide array of disorders. Human immunological studies typically absent a microbiome consideration in their investigations. …

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Unique natural and adaptive response mechanisms to control and eradicate HIV infection

Daniel Amsterdam

During the more than 35 years since the discovery of HIV as the causative agent of AIDS a preventative and/or therapeutic vaccine has not been achieved in spite of innovative and unique break-through discoveries in the diagnosis, monitoring of disease progression and …

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Immunomodulatory interplay of the microbiome and therapy of rheumatic diseases

Barbara E. Ostrov, Daniel Amsterdam

Modulation of the immune system by microbes, especially from the gastrointestinal tract, is increasingly considered a key factor in the onset, course and outcome of rheumatic diseases. The interplay of the microbiome, along with genetic predisposition and environmental exposure, is thought to …

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Index

Daniel Amsterdam

Immunotherapeutic Approaches for the Control and Eradication of HIV

Daniel Amsterdam

Since the onset of the AIDS epidemic over 35 years ago, attempts at immunologic manipulation to develop preventative and therapeutic approaches to HIV infection have been the subject of intense focus by the scientific community. New tactics such as latency reveal agents …

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