Accès ouvert
2025
article
OpenAlex
Franco Luis Lombino, Mohsin Shafiq, Andreu Matamoros‐Angles, Jürgen R. Schwarz et autres
Extracellular vesicles (EVs) are membranous structures that cells release into the extracellular space. EVs carry various molecules such as proteins, lipids, and nucleic acids, and serve as specialized transporters to influence other cells. In the central nervous system, EVs have been linked …
de, au
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Accès ouvert
2024
article
OpenAlex
Liana S. Mkrtchyan, Harutyun Sahakyan, Jodene Eldstrom, Tatev Karapetyan et autres
KCNQ1 potassium channels play a pivotal role in the physiology and pathophysiology of several human excitable and epithelial tissues. The latest cryo-electron microscopy (cryo-EM) structures provide unique insights into channel function and pharmacology, opening avenues for different therapeutic strategies against human diseases …
ca, de
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Accès ouvert
2024
article
OpenAlex
Jürgen R. Schwarz, Sandra Freitag, Yvonne Pechmann, Irm Hermans-Borgmeyer et autres
Potassium channels stabilize the resting potential and neuronal excitability. Among them, erg (ether-à-go-go–related gene) K + channels represent a subfamily of voltage-gated channels, consisting of erg1, erg2, and erg3 subunits; however, their subunit-specific neuronal functions in vivo are barely understood. To find …
de
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Accès ouvert
2023
article
OpenAlex
Franco Luis Lombino, Jürgen R. Schwarz, Yvonne Pechmann, Michaela Schweizer et autres
Dynamic microtubules critically regulate synaptic functions, but the role of microtubule severing in these processes is barely understood. Katanin is a neuronally expressed microtubule-severing complex regulating microtubule number and length in cell division or neurogenesis; however, its potential role in synaptic functions …
de
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Accès ouvert
2023
article
OpenAlex
Astghik Abrahamyan, Jodene Eldstrom, Harutyun Sahakyan, Nare Karagulyan et autres
KCNQ1 voltage-gated K+ channels are involved in a wide variety of fundamental physiological processes and exhibit the unique feature of being markedly inhibited by external K+. Despite the potential role of this regulatory mechanism in distinct physiological and pathological processes, its exact …
am, ca
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Accès ouvert
2022
article
OpenAlex
Mary Muhia, PingAn Yuanxiang, Jan Sedlacik, Jürgen R. Schwarz et autres
Muskelin (Mkln1) is implicated in neuronal function, regulating plasma membrane receptor trafficking. However, its influence on intrinsic brain activity and corresponding behavioral processes remains unclear. Here we show that murine Mkln1 knockout causes non-habituating locomotor activity, increased exploratory drive, and decreased locomotor …
at, de, gb
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Accès ouvert
2022
preprint
OpenAlex
Franco Luis Lombino, Jürgen R. Schwarz, Yvonne Pechmann, Michaela Schweizer et autres
Abstract Dynamic microtubules transiently polymerize into dendritic spines, however intracellular factors that regulate this process and their functional role at synapses are hardly understood. Using live imaging, electrophysiology, and glutamate uncaging, we show that the microtubule-severing complex katanin is located at individual …
de
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Accès ouvert
2021
article
OpenAlex
Jürgen R. Schwarz
Abstract In myelinated nerve fibres, action potentials are generated at nodes of Ranvier. These structures are located at interruptions of the myelin sheath, forming narrow gaps with small rings of axolemma freely exposed to the extracellular space. The mammalian node contains a …
de
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Accès ouvert
2020
article
OpenAlex
André Teixeira Lopes, Torben Johann Hausrat, Frank F. Heisler, Kira V. Gromova et autres
Mutations in the gene encoding the microtubule-severing protein spastin (spastic paraplegia 4 [SPG4]) cause hereditary spastic paraplegia (HSP), associated with neurodegeneration, spasticity, and motor impairment. Complicated forms (complicated HSP [cHSP]) further include cognitive deficits and dementia; however, the etiology and dysfunctional mechanisms …
de
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Accès ouvert
2019
article
OpenAlex
Stephen Graf Brohawn, Weiwei Wang, Annie Handler, Ernest B. Campbell et autres
TRAAK is a membrane tension-activated K+ channel that has been associated through behavioral studies to mechanical nociception. We used specific monoclonal antibodies in mice to show that TRAAK is localized exclusively to nodes of Ranvier, the action potential propagating elements of myelinated …
us, de
(code pays fourni par la source)
Accès ouvert
2019
peer-review
OpenAlex
Stephen Graf Brohawn, Weiwei Wang, Annie Handler, Ernest B. Campbell et autres
The mechanosensitive potassium channel TRAAK is localized to nodes of Ranvier is mammalian axons where it hyperpolarizes the resting potential and may contribute to mechanical repolarization of neurons.
us, de
(code pays fourni par la source)
Accès ouvert
2019
article
OpenAlex
Mona K. Roesler, Franco Luis Lombino, Sandra Freitag, Michaela Schweizer et autres
The actin cytoskeleton is crucial for function and morphology of neuronal synapses. Moreover, altered regulation of the neuronal actin cytoskeleton has been implicated in neuropsychiatric diseases such as autism spectrum disorder (ASD). Myosin XVI is a neuronally expressed unconventional myosin known to …
de
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