Nathan Godfrey

Association Between Duration of Transient Neurological Events and Diffusion‐Weighted Brain Lesions

Raed A. Joundi, Amy Yu, Eric E. Smith, Charlotte Zerna et autres

Background The relationship between duration of transient neurological events and presence of diffusion-weighted lesions by symptom type is unclear. Methods and Results This was a substudy of SpecTRA (Spectrometry for Transient Ischemic Attack Rapid Assessment), a multicenter prospective cohort of patients with …

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Development of an Open Face Home Cage Running Wheel for Testing Activity-Based Anorexia and Other Applications

Nathan Godfrey, Kehan Chen, Temoor Tayyab, Gina Dimitropoulos et autres

Running wheels for mice residing in the home cage are useful for the continuous measurement of locomotor activity for studies testing exercise interventions or exercise-induced effects on brain and metabolism. Here, we have developed an open source, printable, open-faced running wheel that …

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Activation of LH GABAergic inputs counteracts fasting-induced changes in tVTA/RMTG neurons

Nathan Godfrey, Min Qiao, Stephanie L. Borgland

Abstract Dopamine neurons in the ventral tegmental area (VTA) are strongly innervated by GABAergic neurons in the ‘tail of the VTA’ (tVTA), also known as the rostralmedial tegmental nucleus (RMTg). Disinhibition of dopamine neurons through firing of the GABAergic neurons projecting from …

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Dopamine Inputs from the Ventral Tegmental Area into the Medial Prefrontal Cortex Modulate Neuropathic Pain-Associated Behaviors in Mice

Shuo Huang, Zizhen Zhang, Eder Gambeta, Shi Chen Xu et autres

(Cell Reports 31, 107812-1–107812-9.e1–e6; June 23, 2020) In the originally published version of this article, the bars in Figures 2D and 2E were incorrectly superimposed on the individual data points that reflect the experimental measurements. Figures 2D and 2E have now been …

Sex differences in the effect of acute fasting on excitatory and inhibitory synapses onto ventral tegmental area dopamine neurons

Nathan Godfrey, Stephanie L. Borgland

KEY POINTS: Fasting can increase motivation for food and can energize reward-seeking. Ventral tegmental area (VTA) dopamine neurons respond to motivationally relevant information and fasting can influence mesolimbic dopamine concentration. An acute overnight fast differentially alters food approach behaviours and excitatory synaptic …

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Sex differences in the effect of acute fasting on excitatory and inhibitory synapses onto ventral tegmental area dopamine neurons

Nathan Godfrey, Stephanie L. Borgland

Abstract Dopamine neurons in the ventral tegmental area (VTA) are important for energizing goal directed behaviour towards food and are sensitive to changes in metabolic states. Fasting increases the incentive motivation for food, mobilization of energy stores and have sex-dependent effects. However, …

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Evidence for rapid gut clearance of microplastic polyester fibers fed to Chinook salmon: A tank study

Andrew R. Spanjer, Theresa L. Liedtke, Kathleen E. Conn, Lisa K. Weiland et autres

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Dopamine Inputs from the Ventral Tegmental Area into the Medial Prefrontal Cortex Modulate Neuropathic Pain-Associated Behaviors in Mice

Shuo Huang, Zizhen Zhang, Eder Gambeta, Shi Chen Xu et autres

The medial prefrontal cortex (mPFC) is a brain region involved in the affective components of pain and undergoes plasticity during the development of chronic pain. Dopamine (DA) is a key neuromodulator in the mesocortical circuit and modulates working memory and aversion. Although …

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Diversity in the lateral hypothalamic input to the ventral tegmental area

Nathan Godfrey, Stephanie L. Borgland

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