Dosang Lee

Bioactive compounds and multifaceted health benefits of noni (Morinda citrifolia L.) and fermented noni: a review

Ji‐Hyun Im, Xiaolu Fu, Sun‐Il Choi, Jae-Yeon Lee et autres

17-DMAG-Loaded HER2-Targeted Extracellular Vesicles Induce PARP/Caspase3-Mediated Apoptosis in Gastric Carcinoma

Sin Hye Park, Deok Yong Sim, Dosang Lee, Chan Mi Lee et autres

Gastric cancer remains a major clinical challenge, underscoring the need for more effective drug delivery strategies. Approximately 10–20% of gastric cancers overexpress HER2, conferring aggressive tumor characteristics and poor survival, yet resistance to trastuzumab-based targeted therapy and limited intratumoral antibody penetration continue …

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Analysis of the Bioactive Compounds and Physiological Activities of Commonly Consumed Noni Juice in Republic of Korea

Xiaolu Fu, Min-Hye Kim, Geon Oh, Ji‐Hyun Im et autres

L.) juice is increasingly recognized for its potential health-promoting properties. In this research, the bioactive compounds and physiological effects of commercial noni juice products in Korea were assessed. Noni juice was found to contain high levels of total phenolics (6.39 ± 1.45 …

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Rupatadine suppresses tumor growth and EMT in pancreatic cancer: Evidence from in vitro and in vivo models

Byung Ock Choi, Ho Joong Choi, Dosang Lee, Jung Woo Park et autres

Rupatadine, primarily used for treating allergic rhinitis as a selective histamine H1 receptor and platelet‑activating factor antagonist, has potential anticancer properties, specifically through inducing lysosomal membrane permeabilization. The present study explores the efficacy of rupatadine in pancreatic cancer. The study assessed the …

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A novel strategy for sorafenib-resistant hepatocellular carcinoma: autotaxin Inhibition by PF-8380

Bong Jun Kwak, Jung‐Hyun Park, Ok‐Hee Kim, Dosang Lee et autres

By inhibiting the conversion of lysophosphatidylcholine into lysophosphatidic acid, a process pivotal to tumor progression, the autotaxin (ATX) inhibitor PF-8380 offers a new anticancer therapeutic strategy, distinct from the action mechanism of sorafenib. This study explored the potential anticancer effects of the …

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Intraparenchymal Penicillin G Injection Promotes Wound Healing and Lowers POPF in Pigs After Pancreatic Surgery

Jung Hyun Park, Jae Hyun Han, Dosang Lee, Kee‐Hwan Kim et autres

Background: Postoperative pancreatic fistula (POPF) is a significant complication following pancreatic surgery, considerably influenced by the texture of the pancreatic tissue. This study aims to explore the potential of Penicillin G (PG) in reducing the severity of POPF in a porcine surgical …

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Assessing the Efficacy of Mitochondria-Accumulating Self-Assembly Peptides in Pancreatic Cancer: An Animal Study

Ho Joong Choi, Seongeon Jin, Junghyun Park, Dosang Lee et autres

Although pancreatic cancer presents with one of the most unfavorable prognoses, its treatment options are very limited. Mitochondria-targeting moieties, considered a new and prominent treatment modality, are expected to demonstrate synergistic anticancer effects due to their distinct mechanism compared to conventional chemotherapeutic …

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Enhanced drug delivery in cancer therapy: role of TMPRSS4 protease in liposomal engineering

Ji Hoon Kim, Jeong Hun Kwak, Ho Joong Choi, Dosang Lee et autres

Abstract This research centers on leveraging the proteolytic activity of TMPRSS4 (transmembrane protease, serine 4), a transmembrane protease frequently found on tumor cell membranes, for the development of anticancer therapeutics. A novel liposome design was developed, incorporating transmembrane peptides (TMPRSS4-cleavable peptides; TCPs) …

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Synergistic anticancer effects of mitochondria-targeting peptide combined with paclitaxel in breast cancer cells: a preclinical study

Juneyoung Ahn, Ok‐Hee Kim, Song Jin, Ja‐Hyoung Ryu et autres

Purpose: Mitochondria-accumulating amphiphilic peptide (Mito-FF) was designed to selectively target mitochondria in cancer cells and enhance anticancer effects through its unique structure. Mito-FF consists of (1) diphenylalanine, a β-sheet-forming building block critical for self-assembly; (2) triphenylphosphonium, a mitochondrial targeting moiety guiding the …

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Scaffold implantation vs. intravenous delivery: a comparative preclinical animal study evaluating peroxisome proliferator-activated receptor gamma coactivator 1-alpha adipose-derived stem cells in liver fibrosis treatment

Joseph Ahn, Ho Joong Choi, Dosang Lee, Ha‐Eun Hong et autres

Purpose: Regenerative medicine is expected to offer an alternative to liver transplantation for treating liver diseases in the future, with one significant challenge being the establishment of an effective stem cell administration route. This study assessed the antifibrogenic effects of adipose-derived stem …

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Utilizing miR-34a-Loaded HER2-Targeting Exosomes to Improve Breast Cancer Treatment: Insights From an Animal Model

Woo Young Sun, Dosang Lee, Jung Hyun Park, Ok‐Hee Kim et autres

PURPOSE: Exosomes, nanoscale vesicles with high biocompatibility, were engineered to express human epidermal growth factor receptor 2 (HER2)-binding peptides and carry miR-34a, targeting HER2 and programmed death-ligand 1 (PD-L1)-positive breast cancer cells. METHODS: xenograft breast cancer model was established by subcutaneously injecting …

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Profiling of phytochemicals in Adenophora triphylla using LC-Q-TOF/MS-based untargeted metabolomics

Yoonjeong Kim, Jiye Pyeon, Yeong-Eun Yu, Chul-Jong Jung et autres

This study investigated the metabolic changes upon hydrothermal extraction of A. triphylla root, employing untargeted metabolomics analysis.

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