Taíza H. Figueiredo

Persistently Elevated Gamma Power and Delayed Brain Damage in Aged Rats Acutely Exposed to Soman Without Status Epilepticus: Comparisons with Seizing Rats Treated with Midazolam or with Tezampanel and Caramiphen

Taíza H. Figueiredo, Vassiliki Aroniadou-Anderjaska, Marcio de Araujo Furtado, Volodymyr I. Pidoplichko et autres

Aged animals or humans are more susceptible to permanent brain damage from status epilepticus (SE), making the selection of antiseizure medication even more crucial. This study compared the antiseizure and neuroprotective efficacy of midazolam with that of tezampanel combined with caramiphen in …

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Sex-dependent differences in the antiseizure and neuroprotective effects of midazolam after soman exposure: Superior, sex-independent efficacy of tezampanel and caramiphen

Taíza H. Figueiredo, Vassiliki Aroniadou‐Anderjaska, Volodymyr I. Pidoplichko, Marcio de Araujo Furtado et autres

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α-linolenic acid-induced facilitation of GABAergic synaptic transmission is mediated via acid-sensing ion channel (ASIC1a) activity in the basolateral amygdala

Volodymyr I. Pidoplichko, Taíza H. Figueiredo, Maria F. M. Braga, Ann M. Marini

Epilepsy affects more than 70 million people worldwide. A seizure focus that develops in different cortical brain regions can present as either focal or generalized seizures. Temporal lobe epilepsy is a highly pharmacoresistant form of epilepsy that involves the amygdala, hippocampus with …

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Alterations in GABAA receptor-mediated inhibition triggered by status epilepticus and their role in epileptogenesis and increased anxiety

Vassiliki Aroniadou‐Anderjaska, Taíza H. Figueiredo, Marcio de Araujo Furtado, Volodymyr I. Pidoplichko et autres

The triggers of status epilepticus (SE) in non-epileptic patients can vary widely, from idiopathic causes to exposure to chemoconvulsants. Regardless of its etiology, prolonged SE can cause significant brain damage, commonly resulting in the development of epilepsy, which is often accompanied by …

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Mechanisms of Organophosphate Toxicity and the Role of Acetylcholinesterase Inhibition

Vassiliki Aroniadou‐Anderjaska, Taíza H. Figueiredo, Marcio de Araujo Furtado, Volodymyr I. Pidoplichko et autres

Organophosphorus compounds (OPs) have applications in agriculture (e.g., pesticides), industry (e.g., flame retardants), and chemical warfare (nerve agents). In high doses or chronic exposure, they can be toxic or lethal. The primary mechanism, common among all OPs, that initiates their toxic effects …

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Preventing Long-Term Brain Damage by Nerve Agent–Induced Status Epilepticus in Rat Models Applicable to Infants: Significant Neuroprotection by Tezampanel Combined with Caramiphen but Not by Midazolam Treatment

Marcio de Araujo Furtado, Vassiliki Aroniadou‐Anderjaska, Taíza H. Figueiredo, Volodymyr I. Pidoplichko et autres

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Alpha-linolenic acid enhances the facilitation of GABAergic neurotransmission in the BLA and CA1

V.I. Pidoplichko, Taíza H. Figueiredo, Maria F. M. Braga, Hongna Pan et autres

Hyperexcitability is a major mechanism implicated in several neuropsychiatric disorders, such as organophosphate-induced status epilepticus (SE), primary epilepsy, stroke, spinal cord injury, traumatic brain injury, schizophrenia, and autism spectrum disorders. Underlying mechanisms are diverse, but a functional impairment and loss of GABAergic …

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Delayed tezampanel and caramiphen treatment but not midazolam protects against long-term neuropathology after soman exposure

Taíza H. Figueiredo, Vassiliki Aroniadou‐Anderjaska, James P. Apland, Katia Rossetti et autres

Prolonged status epilepticus (SE) can cause brain damage; therefore, treatment must be administered promptly after seizure onset to limit SE duration and prevent neuropathology. Timely treatment of SE is not always feasible; this would be particularly true in a mass exposure to …

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Antiseizure and Neuroprotective Efficacy of Midazolam in Comparison with Tezampanel (LY293558) against Soman-Induced Status Epilepticus

Taíza H. Figueiredo, Vassiliki Aroniadou‐Anderjaska, Volodymyr I. Pidoplichko, James P. Apland et autres

Acute exposure to nerve agents induces status epilepticus (SE), which can cause death or long-term brain damage. Diazepam is approved by the FDA for the treatment of nerve agent-induced SE, and midazolam (MDZ) is currently under consideration to replace diazepam. However, animal …

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GABAergic circuits of the basolateral amygdala and generation of anxiety after traumatic brain injury

Maria F. M. Braga, Jenifer J. Juranek, Lee E. Eiden, Zheng Li et autres

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Increased inhibitory activity in the basolateral amygdala and decreased anxiety during estrus: A potential role for ASIC1a channels

Volodymyr I. Pidoplichko, Vassiliki Aroniadou‐Anderjaska, Taíza H. Figueiredo, Camilla Wilbraham et autres

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Acetylcholinesterase inhibitors (nerve agents) as weapons of mass destruction: History, mechanisms of action, and medical countermeasures

Vassiliki Aroniadou‐Anderjaska, James P. Apland, Taíza H. Figueiredo, Marcio de Araujo Furtado et autres

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