Jeeban P. Das

CT-Derived Predictors of Incisional Hernia Following Colorectal Cancer Resection: A Systematic Review

Mohamed Alfatih Hamza, Omar Abu Saadeh, Hugo C. Temperley, Niall J. O’Sullivan et autres

Background/Objectives: To systematically review computed tomography (CT)-derived body composition and morphological predictors of incisional hernia (IH) following colorectal cancer (CRC) resection. Methods: PubMed/MEDLINE, Embase, Scopus, Web of Science, Cochrane Library, and CINAHL were searched from inception to May 2026, supplemented by grey …

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A phase 2 trial of IO102-IO103 and nivolumab-relatlimab in previously untreated, unresectable melanoma.

James W. Smithy, Hannah L. Kalvin, Jaykumar Thumar, Alexander Shoushtari et autres

9519 Background: IO102-IO103 is an investigational cancer vaccine that targets both tumor and immune-suppressive cells in the tumor microenvironment. IO102-IO103 has demonstrated clinical activity in combination with anti-PD-1 monotherapy in advanced melanoma, with concordant clonal T cell expansion observed in the tumor …

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CCTG BR.38: Consolidative use of radiotherapy to block (CURB2) oligoprogression in patients with metastatic non–small-cell lung cancer—A randomized phase III trial.

CJillian Tsai, A SUN, Penelope Ann Bradbury, Devin Schellenberg et autres

TPS8124 Background: Immune checkpoint inhibitor (ICI)–based regimens are standard first-line therapy for metastatic non–small-cell lung cancer (NSCLC) without actionable driver mutations; however, most patients experience disease progression within 12 months. A subset develop oligoprogression, defined by progression at a limited number of …

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Long-standing Large Nonfunctional Cardiac Paraganglioma

Thomas Martin Schwedhelm, Jeeban P. Das

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Precision imaging and evolving therapies in paragangliomas and pheochromocytomas: from molecular diagnostics to imaging-guided management

Aurélie Choucair, Anna Zdunek, Matthew J. Liao, Lisa Bodei et autres

Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors originating from neural crest-derived chromaffin tissue, marked by clinical heterogeneity and substantial genetic underpinnings. With up to 70% of cases linked to germline or somatic mutations, including Succinate DeHydrogenase genetic alterations (SDHx), and Von …

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Cancer-Associated Fibroblasts: Clinical Applications in Imaging and Therapy

Neda Nilforoushan, Ashkan Khavaran, Maierdan Palihati, Yashvi Patel et autres

Cancer-associated fibroblasts (CAFs) are an abundant and diverse cell population within tumor microenvironments of solid tumors. Multiple subtypes of CAFs, defined by molecular and functional markers, have been described in the literature. CAFs contribute to tumor progression by remodeling the extracellular matrix, …

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Impact of Tumor Shape on Local Staging Accuracy Using VI-RADS in Bladder Cancer: Implications for MRI Protocol Selection

Yuki Arita, Thomas C. Kwee, Keisuke Shigeta, Noam Nissan et autres

Motivation: Accurate local staging of bladder cancer is essential for guiding treatment decisions. However, the influence of tumor morphology on diagnostic performance of VI-RADS remains unclear. Goal(s): To examine how the shape of bladder tumors influences the diagnostic accuracy of biparametric MRI …

Emerging PET Imaging Agents and Targeted Radioligand Therapy: A Review of Clinical Applications and Trials

Maierdan Palihati, Jeeban P. Das, Randy Yeh, Kathleen M. Capaccione

Targeted radioligand therapy (RLT) is an emerging field in anticancer therapeutics with great potential across tumor types and stages of disease. While much progress has focused on agents targeting somatostatin receptors and prostate-specific membrane antigen (PSMA), the same advanced radioconjugation methods and …

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The evolving role of multimodal imaging, artificial intelligence and radiomics in the radiologic assessment of immune related adverse events

Jeeban P. Das, Yanjun Hong, Conor Prendergast, Alireza Baniasadi Dahooiyeh et autres

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Real-world clinical outcomes of sacituzumab govitecan after prior exposure to enfortumab vedotin in patients with metastatic urothelial carcinoma

Michal Sternschuss, Nicolas Toumbacaris, Jeeban P. Das, T. Powles et autres

BACKGROUND: Sacituzumab govitecan (SG) is an antibody-drug conjugate associated with clinically meaningful responses as advanced-line treatment of metastatic urothelial carcinoma (mUC). Practically, SG has been most commonly used in the post-enfortumab vedotin (EV) setting, but data are scarce regarding the efficacy in …

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Single dose of neoadjuvant ipilimumab and nivolumab in resectable melanoma with CD8+ cell imaging: Interim results of the C-IT Neo trial.

Sarah E. Lochrin, Cecilia Lezcano, James Russell, Jeeban P. Das et autres

9513 Background: Neoadjuvant (neoadj) immune checkpoint blockade (ICB) is standard of care for patients (pts) with resectable stage III/IV melanoma. A single ICB dose induces substantial peripheral immune activation and 1 dose of neoadj pembrolizumab has promising activity. The efficacy of 1 …

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Natural Language Processing of Radiology Reports to Assess Survival in Patients with Advanced Melanoma

Jeeban P. Das, Jordan Eichholz, Varadan Sevilimedu, Natalie Gangai et autres

Background/Objectives: To use natural language processing (NLP) to extract large-scale data from the CT radiology reports of patients with advanced melanoma treated with immunotherapy and to determine whether liver metastases affect survival. Methods: Patient criteria (M1 disease subclassified into M1a, M1b, or …

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