Isobel Marion Harris

Methodological development for core outcome sets in population health research: a mixed-methods study

Ameeta Retzer, Peymané Adab, Melanie Jane Calvert, Niyah Campbell et autres

BACKGROUND: Core outcome sets (COS) aid evidence synthesis and promote relevance of and reduce waste from trials. COS are commonly used in biomedical research settings, but their application in population health research is less established. There is growing interest in using COS …

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Methodological review reveals essential gaps and inconsistencies in clinical claims, effects, and outcomes in HTA reviews of diagnostic tests

Jacqueline Dinnes, Clare F Davenport, Isobel Marion Harris, Lavinia Ferrante di Ruffano et autres

BACKGROUND AND OBJECTIVE: Essential first steps in performing a health technology assessment (HTA) for a diagnostic test include consideration of the clinical pathway in which the test will be used, specifying the clinical claim for the test (how the test may add …

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A systematic review and network meta-analysis of interventions to preserve insulin-secreting beta cell function in people newly diagnosed with type 1 diabetes: results from randomised controlled trials of immunomodulatory therapies

Sophie Elizabeth Beese, Malcolm James Price, Claire L Tomlinson, Pawana Sharma et autres

Abstract Background Type 1 diabetes is characterised by the immune-mediated destruction of pancreatic beta cells. We aimed to determine the effectiveness of immunotherapies for preserving residual beta cell function in newly diagnosed (stage 3) type 1 diabetes. Methods Searches were carried out …

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Methodological Review of Clinical Claims, Effects and Outcomes in Hta Reviews of Diagnostic Tests Shows Lack of Coherence

Jacqueline Dinnes, Clare F Davenport, Isobel Marion Harris, Lavinia Ferrante di Ruffano et autres

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Barriers and Facilitators to Physical Activity Among Older Adults in Residential Aged Care Facilities: A Mixed Methods Systematic Review Using the Social Ecological Model

Sumana Baidya, Cathy Connolly, Jasmine Maria Petersen, Claire E. Baldwin et autres

Objective To ascertain the barriers and facilitators to physical activity (PA) for older adults in Residential Aged Care Facilities (RACFs), from the perspective of residents, staff, and family. Methods A mixed-methods systematic review, underpinned by the Social Ecological Model (SEM). Five databases …

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Experiences as a clinical teaching fellow: interviews with clinical teaching fellows in the West Midlands

Isobel Marion Harris, Nicola Dennis, Derek J. Ward, Alice J. Sitch et autres

BACKGROUND: The majority of junior doctors in the UK do not proceed directly into specialty training after completing mandatory foundation training but instead take a year out of training. A common post undertaken during a year out of training is a clinical …

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The Clinical Teaching Fellow role: exploring expectations and experiences

Isobel Marion Harris, Heather McNeilly, Derek J. Ward, Alice J. Sitch et autres

BACKGROUND: Many UK junior doctors are now taking a year out of the traditional training pathway, usually before specialty training, and some choose to work as a clinical teaching fellow (CTF). CTFs primarily have responsibility for delivering hospital-based teaching to undergraduate medical …

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Pressure-garment therapy for preventing hypertrophic scarring after burn injury

Isobel Marion Harris, Kwang Chear Lee, Jonathan J Deeks, David Moore et autres

BACKGROUND: Burn damage to skin often results in scarring; however in some individuals the failure of normal wound-healing processes results in excessive scar tissue formation, termed 'hypertrophic scarring'. The most commonly used method for the prevention and treatment of hypertrophic scarring is …

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A toolkit for capturing a representative and equitable sample in health research

Ameeta Retzer, Bircan Ciytak, Foram Khatsuria, Juma El-Awaisi et autres

Research participants often do not represent the general population. Systematic exclusion of particular groups from research limits the generalizability of research findings and perpetuates health inequalities. Groups considered underserved by research include those whose inclusion is lower than expected based on population …

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The Clinical Teaching Fellow role: views of the Heads of Academy in the West Midlands

Isobel Marion Harris, Sheila Greenfield, Derek J. Ward, Alice J. Sitch et autres

BACKGROUND: Increasingly junior doctors are taking a year out of the traditional training pathway, and some opt to spend a year in a clinical teaching fellow (CTF) post. The CTF post mainly involves delivering hospital-based teaching to undergraduate medical students. In NHS …

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Health technology assessment of diagnostic tests: a state of the art review of methods guidance from international organizations

Lavinia Ferrante di Ruffano, Isobel Marion Harris, Zhivko Zhelev, Clare F Davenport et autres

OBJECTIVES: To identify which international health technology assessment (HTA) agencies are undertaking evaluations of medical tests, summarize commonalities and differences in methodological approach, and highlight examples of good practice. METHODS: A methodological review incorporating: systematic identification of HTA guidance documents mentioning evaluation …

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Long-term impact of pre-incision antibiotics on children born by caesarean section: a longitudinal study based on UK electronic health records

Dana Šumilo, Krishnarajah Nirantharakumar, Brian H Willis, Gavin Rudge et autres

BACKGROUND: Since changes in the national guidance in 2011, prophylactic antibiotics for women undergoing caesarean section are recommended prior to skin incision, rather than after the baby's umbilical cord has been clamped. Evidence from randomised controlled trials conducted outside the UK has …

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