Wannan Chen

Epstein-Barr virus-encoded microRNA-BART17-5p suppresses cell proliferation and metastasis by targeting CERK

Peilin Wu, Xiazhen Xu, Qiong Wu, Lu Zhang et autres

Epstein-Barr virus (EBV) is an oncogenic DNA virus that is etiologically associated with multiple malignancies, including nasopharyngeal carcinoma, gastric carcinoma, and lymphomas. Although EBV encodes numerous viral microRNAs (miRNAs), the pathogenic functions of individual miRNAs remain incompletely characterized. In this study, we …

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Hepatitis B Doubly Spliced Protein (HBDSP) Promotes Epithelial‐Mesenchymal Transition, Migration, and Invasion via SP1/ETS1‐Dependent YAP Activation in Hepatoma Cells

Xiazhen Xu, Yibin Peng, Yuxin Ping, Tiantian Shao et autres

Chronic hepatitis B virus (HBV) infection remains a significant global health burden. Although the canonical HBV proteins are well-studied, the pathological roles of HBV spliced variants and their encoded proteins are poorly understood. In this study, we investigate the cancer-promoting potential of …

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Long-Term Follow-Up from MajesTEC-1 China Cohort of Teclistamab in Patients with Relapsed/Refractory Multiple Myeloma: Efficacy Updates, Infection Profile and Immunoglobulin Usage

Zhen Cai, Zhongjun Xia, Aili He, Yujun Dong et autres

Exploring biomarkers for diagnosing and predicting organ dysfunction in patients with perioperative sepsis: a preliminary investigation

Linghui Jiang, Shiyu Chen, Shichao Li, Jiaxing Wang et autres

OBJECTIVE: Early diagnosis and prediction of organ dysfunction are critical for intervening and improving the outcomes of septic patients. The study aimed to find novel diagnostic and predictive biomarkers of organ dysfunction for perioperative septic patients. METHOD: This is a prospective, controlled, …

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Effect of clock rhythm on emergence agitation and early postoperative delirium in older adults undergoing thoracoscopic lung cancer surgery: protocol for a prospective, observational, cohort study

Linghui Jiang, Jie Wang, Wannan Chen, Zhiyao Wang et autres

INTRODUCTION: Surgeries conducted at night can impact patients' prognosis, and the mechanism may be related to circadian rhythm, which influence normal physiological functions and pathophysiological changes. Melatonin is primarily a circadian hormone with hypnotic and chronobiotic effects, thereby affecting disease outcomes through …

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Association of clonal haematopoiesis with severe postoperative complications in patients undergoing radical oesophagectomy

Hao Wang, Huan Yan, Wannan Chen, Han Tang et autres

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Hepatitis B doubly spliced protein (HBDSP) promotes hepatocellular carcinoma cell apoptosis via ETS1/GATA2/YY1-mediated p53 transcription

Xiazhen Xu, Lu Zhang, Guiying Ye, Jiajian Shi et autres

ABSTRACT Chronic hepatitis B virus (HBV) infection represents an important global public health concern. The spliced variants generated by RNA splicing from 3.5-kb HBV pre-genomic RNA are involved in chronic hepatitis B pathogenicity and associated with hepatocellular carcinoma development. Although the HBV …

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Effect of music on hemodynamic fluctuations in women during induction of general anesthesia: a prospective randomized controlled multicenter trial

Jie Wang, Linghui Jiang, Wannan Chen, Zhiyao Wang et autres

Abstract Background Anxiety can cause perioperative stress and increase sympathetic nervous system activity, potentially contributing to negative clinical outcomes, including hemodynamic instability, prolonged anesthesia induction and cardiac arrhythmias. We aim to investigate the effect of music on hemodynamic fluctuations during induction of …

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Opioid-Free Versus Opioid-Based Anesthesia on Postoperative Pain After Thoracoscopic Surgery: The Use of Intravenous and Epidural Esketamine

Huan Yan, Wannan Chen, Youwen Chen, Huayuan Gao et autres

BACKGROUND: The effectiveness and safety of opioid-free anesthesia (OFA) regimens in distinct types of surgeries remain controversial. In this study, we investigated whether OFA could reduce the occurrence of chronic postoperative pain in patients receiving video-assisted thoracoscopic surgery (VATS). METHODS: We conducted …

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Endoskeletal coacervates with mobile-immobile duality for long-term utility

Wannan Chen, Shuqin Zheng, Fengxiang Zhou, Yangkun Huang et autres

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Chromatin remodelling factor BAF155 protects hepatitis B virus X protein (HBx) from ubiquitin-independent proteasomal degradation

Huijing Chen, Yi Zhang, Shuangshuang Ye, Qiong Wu et autres

HBx is a short-lived protein whose rapid turnover is mainly regulated by ubiquitin-dependent proteasomal degradation pathways. Our prior work identified BAF155 to be one of the HBx binding partners. Since BAF155 has been shown to stabilize other members of the SWI/SNF chromatin …

Hepatitis B Virus X Protein Is Stabilized by the Deubiquitinating Enzyme VCPIP1 in a Ubiquitin-Independent Manner by Recruiting the 26S Proteasome Subunit PSMC3

Qiong Wu, Lu Zhang, Xiazhen Xu, Yi Zhang et autres

HBx is a multifunctional viral oncoprotein that plays an essential role in the viral life cycle and hepatocarcinogenesis. HBx degradation occurs through the ubiquitin-proteasome system (UPS). However, whether novel compartments of the DUBs in the UPS also act in regulating HBx stability …

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