Yoshinori Ohashi

Antihyperglycemic Effect of Insulin from Self-Dissolving Micropiles in Dogs

Yukako Ιtο, Yoshinori Ohashi, Atsushi Saeki, Nobuyuki Sugioka et autres

As a percutaneous delivery device, self-dissolving micropiles (SDMPs) composed of chondroitin sulfate and insulin were prepared under room temperature from highly concentrated solution, glue. The mean weight of SDMP was 1.03+/-0.04 mg. One insulin SDMP was percutaneously administered to the shaved abdominal …

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Self-Dissolving Micropiles for the Percutaneous Absorption of Recombinant Human Growth Hormone in Rats

Yukako Ιtο, Yoshinori Ohashi, Keiji Shiroyama, Nobuyuki Sugioka et autres

The feasibility of self-dissolving micropiles (SDMP) as a percutaneous delivery system of recombinant human growth hormone (rhGH) has been studied in rats using SDMP where dextran was used as a base. After mixing dextran solution with rhGH, SDMPs were prepared by pulling …

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Pharmacokinetic and pharmacodynamic studies following percutaneous absorption of erythropoietin micropiles to rats

Keiji Shiroyama, J. Yoshimitsu, Yoshinori Ohashi, Nobuyuki Sugioka et autres

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Pharmacokinetic and pharmacodynamic studies following oral administration of erythropoietin mucoadhesive tablets to beagle dogs

Natarajan Venkatesan, J. Yoshimitsu, Yoshinori Ohashi, Nobuyuki Sugioka et autres

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