Janelle C. Arthur

Yersiniabactin-Producing Adherent/Invasive Escherichia coli Promotes Inflammation-Associated Fibrosis in Gnotobiotic Il10−/− Mice

Florian Rieder, Laura Fulbright, Lacey R. Lopez, Belgin Dogan et autres

Fibrosis is a significant complication of intestinal disorders associated with microbial dysbiosis and pathobiont expansion, notably Crohn's disease (CD). Mechanisms that favor fibrosis are not well understood, and therapeutic strategies are limited. Here we demonstrate that colitis-susceptible Il10-deficient mice develop inflammation-associated fibrosis …

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Yersiniabactin-producing adherent-invasive Escherichia coli exploit host glycolysis to drive macrophage HIF-1α stabilization

Lance Thurlow, Nathaniel J. Moorman, Marlus S. Pedrosa, Janelle C. Arthur et autres

The siderophore yersiniabactin (Ybt) produced by a subset of intestinal adherent-invasive Escherichia coli (AIEC) drive intestinal fibrosis in murine model of Crohn's disease (CD). This is linked to the Ybt-induced disruption of host metal homeostasis and activation of the hypoxia-inducible factor 1-alpha …

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Yersiniabactin-producing adherent-invasive Escherichia coli exploit host glycolysis to drive macrophage HIF-1α stabilization

Marlus da Silva Pedrosa, J Ames O. K Ahn, John D. Sears, Kimberly A. Walker et autres

The siderophore yersiniabactin (Ybt) produced by a subset of intestinal adherent-invasive Escherichia coli (AIEC) drive intestinal fibrosis in murine model of Crohn’s disease (CD). This is linked to the Ybt-induced disruption of host metal homeostasis and activation of the hypoxia-inducible factor 1–alpha …

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Engineered Probiotic Saccharomyces boulardii Reduces Colitis-Associated Colorectal Cancer Burden in Mice

Krithika Senthil, Anthony Hazelton, Rani S. Sellers, Tyler Culpepper et autres

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From inflammation to fibrosis and cancer: the emerging role of AIEC-derived metabolites in intestinal disease progression

J Ames O. K Ahn, Anthony Hazelton, Juliane Nguyen, Janelle C. Arthur

The intestinal microbiota maintains mucosal homeostasis through dynamic host-microbe interactions. When this balance is disrupted, gut dysbiosis drives inappropriate immune activation, leading to dysregulated inflammation that contributes to the pathogenesis of chronic inflammatory diseases, including inflammatory bowel diseases (IBD). Chronic inflammation in …

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Su1483 YERSINIABACTIN-DRIVEN MACROPHAGE REPROGRAMMING REVEALS PATHWAYS LINKING AIEC TO CHRONIC INFLAMMATION AND INTESTINAL FIBROSIS

Ju-Hyun Ahn, Chuang Li, Janelle C. Arthur

Su1483 YERSINIABACTIN-DRIVEN MACROPHAGE REPROGRAMMING REVEALS PATHWAYS LINKING AIEC TO CHRONIC INFLAMMATION AND INTESTINAL FIBROSIS

Ju-Hyun Ahn, Chuang Li, Janelle C. Arthur

Targeted and quantitatively modeled biologic delivery via dual-functional probiotic yeast in inflammatory bowel disease

Anthony Hazelton, Mairead K. Heavey, Jessica R. Vlcek, Ameya Chaudhari et autres

Probiotic-based therapies are an emerging class of therapeutic interventions that offer a promising strategy for managing chronic and inflammatory conditions. Here, we engineered a dual-functional probiotic yeast strain, Saccharomyces boulardii , designed to target inflammatory lesions within the gastrointestinal tract and locally …

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Adherent-invasive Escherichia coli in Crohn’s disease: the 25th anniversary

Nicolas Barnich, Janelle C. Arthur, Anthony Buisson, Barry J. Campbell et autres

In 1998, Arlette Darfeuille-Michaud, Christel Neut and Jean-Frederic Colombel discovered a novel pathovar of Escherichia coli , adherent and invasive Escherichia coli (AIEC), in the ileum of patients with Crohn’s disease (CD), that was genetically distinct from diarrheagenic E. coli , could …

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Engineered Probiotic Saccharomyces boulardii Reduces Colitis-Associated Colorectal Cancer Burden in Mice

Tyler Culpepper, Krithika Senthil, Anthony Hazelton, Mairead K. Heavey et autres

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INTESTINAL E.COLI-PRODUCED YERSINIABACTIN INDUCES ZINC-DEPENDENT HIF-1A ACTIVATION TO PROMOTE PRO-FIBROTIC MACROPHAGES IN CROHN’S DISEASE

Ju-Hyun Ahn, Marlus da Silva Pedrosa, Lacey R. Lopez, Taylor Tibbs et autres

INTESTINAL E.COLI-PRODUCED YERSINIABACTIN INDUCES ZINC-DEPENDENT HIF-1A ACTIVATION TO PROMOTE PRO-FIBROTIC MACROPHAGES IN CROHN’S DISEASE

Ju-Hyun Ahn, Marlus da Silva Pedrosa, Lacey R. Lopez, Taylor Tibbs et autres

Abstract Inflammatory bowel disease (IBD)-associated fibrosis causes significant morbidity. Mechanisms are poorly understood, but implicate the microbiota, especially adherent-invasive Escherichia coli (AIEC). We previously demonstrated that AIEC producing the metallophore yersiniabactin (Ybt) promote intestinal fibrosis in an IBD mouse model. Since macrophages …