Sara Yubero

Hyperinsulinemia due to altered insulin secretion contributes to insulin resistance in chronic intermittent hypoxia independently of obesity

Joana F. Sacramento, Bernardete F. Melo, Elena Olea, Ana Obeso et autres

Clinical studies have demonstrated a link between obstructive sleep apnea (OSA) and insulin resistance (IR), however it is not clear which is the main event that determines IR development. We hypothesize that hyperinsulinemia is a main driver of IR in chronic intermittent …

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High fat diet blunts the effects of leptin on ventilation and on carotid body activity

Maria J. Ribeiro, Joana F. Sacramento, Teresa Gallego‐Martin, Elena Olea et autres

Key points Leptin plays a role in the control of breathing, acting mainly on central nervous system; however, leptin receptors have been recently shown to be expressed in the carotid body (CB), and this finding suggests a physiological role for leptin in …

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Age protects from harmful effects produced by chronic intermittent hypoxia

Miguel Quintero, Elena Olea, Sílvia V. Conde, Ana Obeso et autres

Key points Episodes of intermittent hypoxia, as produced in obstructive sleep apnoea, cause a carotid‐driven sympathetic hyperactivity and an oxidative status leading to cardiovascular and metabolic pathologies, which are less pronounced in patients >60–65 years old. In young rats (3–4 months) chronic …

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From carotid body oxygen sensing to chronic intermittent hipoxia effects on spontaneous tumorigenesis. The journey of Constancio’s group

Teresa Gallego‐Martin, Asunción Rocher, Teresa Agapito, Ángela Gómez-Niño et autres

Resumen del trabajo presentado al XXXVIII Congreso de la Sociedad Española de Ciencias Fisiológicas (SECF), celebrado en Zaragoza del 13 al 16 de septiembre de 2016.

LATE-BREAKING ABSTRACT: Effects of long term intermittent hypoxia (IH) mimicking obstructive sleep apnea (OSA) on spontaneous tumorigenesis in aged mice

Teresa Gallego‐Martin, Ana Obeso, Sara Yubero, Elena Olea et autres

Background: Recent studies have reported, albeit with discrepancies, an association between severity of OSA and cancer incidence/mortality. Discrepancies are likely due to the large number of OSA-linked comorbidities and uncontrolled variables among patients.In mice, short term IH mimicking OSA augments tumour growth …

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Hypoxic pulmonary vasoconstriction, carotid body function and erythropoietin production in adult rats perinatally exposed to hyperoxia

Jesús Prieto‐Lloret, María José Ramírez-Bajo, Elena Olea, Javier Moral‐Sanz et autres

KEY POINTS: Adult animals that have been perinatally exposed to oxygen-rich atmospheres (hyperoxia), recalling those used for oxygen therapy in infants, exhibit a loss of hypoxic pulmonary vasoconstriction, whereas vasoconstriction elicited by depolarizing agents is maintained. Loss of pulmonary hypoxic vasoconstriction is …

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Disclosing caffeine action on insulin sensitivity: Effects on rat skeletal muscle

Joana F. Sacramento, Maria J. Ribeiro, Sara Yubero, Bernardete F. Melo et autres

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sleep apnea kinetics and cardiovascular responses in obstructive and oxygen supplementation on norepinephrine Effects of nasal continuous positive airway pressure

Paul J. Mills, Brian P. Kennedy, José S. Loredo, Joel E. Dimsdale et autres

Experimental Observations on the Biological Significance of Hydrogen Sulfide in Carotid Body Chemoreception

Teresa Gallego‐Martin, Teresa Agapito, María José Ramírez-Bajo, Elena Olea et autres

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The Carotid Body Does Not Mediate the Acute Ventilatory Effects of Leptin

Elena Olea, Maria J. Ribeiro, Teresa Gallego‐Martin, Sara Yubero et autres

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Intermittent hypoxia and diet-induced obesity: effects on oxidative status, sympathetic tone, plasma glucose and insulin levels, and arterial pressure

Elena Olea, M. T. Agapito, Teresa Gallego‐Martin, Asunción Rocher et autres

Obstructive sleep apnea (OSA) consists of sleep-related repetitive obstructions of upper airways that generate episodes of recurrent or intermittent hypoxia (IH). OSA commonly generates cardiovascular and metabolic pathologies defining the obstructive sleep apnea syndrome (OSAS). Literature usually links OSA-associated pathologies to IH …

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Fernando de Castro and the discovery of the arterial chemoreceptors

Constancio González, Sílvia V. Conde, Elena Olea, Elvira González-Obeso et autres

When de Castro entered the carotid body (CB) field, the organ was considered to be a small autonomic ganglion, a gland, a glomus or glomerulus, or a paraganglion. In his 1928 paper, de Castro concluded: "In sum, the Glomus caroticum is innervated …

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