Christophe Van Steenkiste

Ampullary Actinomycosis Mimicking Malignancy: A Case Report and Literature Review

J Bousson, Christophe Van Steenkiste, Charlotte Gabriel, Vincent Bouderez et autres

This case discusses a 76-year-old female patient with a large mass at the major papilla of Vater, initially suspected to be an ampullary adenoma. The lesion, identified during an upper endoscopy for anemia and fatigue, showed chronic inflammation but no malignancy. The …

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Is FIB-4 the right tool for screening for liver fibrosis?

Leen JM. Heyens, Demi P.A.van Malde, Gediz Dogay Us, Francesco Innocenti et autres

INTRODUCTION AND OBJECTIVES: The screening accuracy of non-invasive fibrosis tests like FIB-4 in metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear. Using standard cut-offs, this study evaluated FIB-4's agreement with vibration-controlled transient elastography (VCTE) and identified and validated new thresholds. PATIENTS AND …

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Prevalence and Risk Factors of MASLD in Prediabetes and Type 2 Diabetes Mellitus in Belgium and The Netherlands

Leen Heyens, Francesco Innocenti, Christophe Van Steenkiste, Mathieu Struyve et autres

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely intertwined with glucose metabolism status (GMS). Bi-national comparative epidemiological data are lacking; therefore, this study aimed to provide new insights into MASLD and fibrosis prevalence and risk factors in Belgium, while comparing data …

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Clinical Trial: Hepatitis B Virus Genotype and a Combination of End‐of‐Treatment Biomarkers Predict Severe Flares After Nucleos(t)ide Analogue Cessation

Arno Furquim d’Almeida, Axelle Vanderlinden, Stefan Bourgeois, Jean‐Pierre Mulkay et autres

BACKGROUND: Nucleos(t)ide analogue (NUC) cessation can induce a functional cure in chronic hepatitis B virus (HBV) infections, but severe post-cessation virologic relapses (SVRel) and severe biochemical flares (SBF) frequently occur. AIMS: To identify predictive biomarkers for patients at highest risk for SVRel …

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THU-323 A larger decline of IgG after initiation of treatment in patients with AIH is associated with complete biochemical response despite having normal baseline IgG levels

Lorenz Grossar, Sarah Raevens, Anja Geerts, Christophe Van Steenkiste et autres

SAT-248-YI End of treatment anti-HBc IgG and HBcrAg predict severe flares after nucleos(t)ide analogue withdrawal in CHB – interim analysis from the multicenter prospective COIN-B trial

Arno Furquim d’Almeida, Axelle Vanderlinden, Stefan Bourgeois, Jean‐Pierre Mulkay et autres

SAT-304 Insufficient implementation of pretherapeutic hepatitis B and C screening guidelines in academic and general belgian hospitals

Marie Coessens, Jolien de Graeve, Wim Verlinden, Anja Geerts et autres

THU-031 MASLD impacts quality of life and work productivity

Leen Heyens, Christophe Van Steenkiste, Yves Kockaerts, Ine Lowyck et autres

Role of astrocytes and microglia in hepatic encephalopathy associated with advanced chronic liver disease: lessons from animal studies

Wouter Claeys, Anja Geerts, Lien Van Hoecke, Christophe Van Steenkiste et autres

Hepatic encephalopathy, defined as neuropsychiatric dysfunction secondary to liver disease, is a frequent decompensating event in cirrhosis. Its clinical impact is highlighted by a notable increase in patient mortality rates and a concomitant reduction in overall quality of life. Systemically, liver disease, …

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Zoönotisch belang van gastrale Helicobacter-species die voorkomen bij katten, honden en varkens

Emily Taillieu, Christophe Van Steenkiste, Koen Chiers, Freddy Haesebrouck

Sinds enkele decennia is bekend dat de maag geen steriele omgeving is. In de diergeneeskunde zijn er tal van niet-Helicobacter pylori Helicobacter (NHPH) species die de maag van onder andere katten, honden en varkens koloniseren. Binnen de humane geneeskunde werd tot voor …

Ferroptosis is a targetable detrimental factor in metabolic dysfunction-associated steatotic liver disease

Cédric Peleman, Stig Hellemans, Geraldine Veeckmans, Wout Arras et autres

There is an unmet clinical need for pharmacologic treatment for metabolic dysfunction-associated steatotic liver disease (MASLD). Hepatocyte cell death is a hallmark of this highly prevalent chronic liver disease, but the dominant type of cell death remains uncertain. Here we report that …

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External validation of the IAIHG autoimmune hepatitis response criteria in a multicentric real-world cohort

Lorenz Grossar, Sarah Raevens, Christophe Van Steenkiste, Isabelle Colle et autres

Background & Aims: The goal of treatment in autoimmune hepatitis (AIH) is induction of remission to prevent the development of liver fibrosis, cirrhosis, and its related complications. Various definitions of treatment response and remission have been used. The International Autoimmune Hepatitis Group …

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