Alessandra Marconi

Inhibiting HuR-Mediated mRNA Stabilization Attenuates Psoriasis-Like Inflammation in Preclinical Models

Dalila Paladino, Claudio Giacinto Atene, Martina Paganin, Elisabetta Palazzo et autres

Purpose: Psoriasis is a chronic inflammatory skin disease characterized by hyperproliferative keratinocytes and activated Th17/Th1 lymphocytes, which sustain a self-perpetuating cycle by releasing pro-inflammatory cytokines. The RNA-binding protein (RBP) Human Antigen R (HuR) stabilizes many of these cytokine mRNAs, contributing to disease …

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Soluble Fas Ligand, an overlooked target of therapy in dermatological and non-dermatological conditions

Roberta Lotti, Brydon Bennett, Alessandra Marconi, Antonino Amato et autres

BACKGROUND: The Fas/Fas Ligand (Fas/FasL) system mediates key physiological and pathological pathways. Therapies targeting this system are currently unavailable due to the complexity of the Fas/FasL pathway and the side effects associated with reduced apoptosis of cancer cells and the lack of …

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Tadalafil-loaded liposomes for localized glans delivery: ex vivo and in vitro 3D model validation

Greta Camilla Magnano, Ilaria Andreana, Silvia Arpicco, Elisabetta Palazzo et autres

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MMP2‐Responsive Liposomes Targeting LDLR Enhance the Effectiveness of Anti‐Cancer Drugs in Treating Melanoma

Antonio Renda, A.V. Antoniou, Marika Quadri, Susanna Comi et autres

ABSTRACT Current cancer therapies for solid cancers involve surgery, radiotherapy, and chemotherapy, but challenges such as tumor heterogeneity, drug resistance, and poor drug delivery hinder effective treatment. Nano‐oncology, specifically liposomes, shows promise by improving drug delivery through better pharmacokinetics and targeting, minimizing …

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125 Treatment of pemphigus and other neglected skin conditions with PC111, a human anti-Fas Ligand monoclonal antibody: a potential disease modifier

Carlo Pincelli, Roberta Lotti, Brydon L. Bennett, Alessandra Marconi et autres

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318 Inhibition of HuR/Elavl1 activity in human primary keratinocytes and T cells as a new therapeutic strategy for psoriasis

David Paladino, Claudio Giacinto Atene, E. Palazzo, M.I. Quadri et autres

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013 Generation of a humanized Fas Ligand mouse and its application in pemphigus: a new platform for the study of PC111 antibody

Roberta Lotti, Alessandra Marconi, Elisabetta Palazzo, M.I. Quadri et autres

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481 Andrographis paniculata extract promotes skin homeostasis through synergistic effects on human epidermal stem cells and their microenvironment

Roberta Lotti, L. Cattuzzato, Xinxin Huang, David Garandeau et autres

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Trk Signaling Inhibition Reduces cSCC Growth and Invasion in In Vitro and Zebrafish Models and Enhances Photodynamic Therapy Outcome

Marika Quadri, Natascia Tiso, Marco Iuliano, Paolo Rosa et autres

Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer, with a rising global incidence. Neurotrophins (NTs) and their receptors, including TrkA and CD271, play key roles in epidermal homeostasis and tumor progression. We showed that CD271 expression and function …

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CD271 orchestrates skin structure, differentiation, and inflammation via PI3K/Akt and PKCα/ERK pathways

Marika Quadri, Luca Reggiani Bonetti, Cristina Pellegrini, Mirco Mastrangelo et autres

The involvement of the neurotrophin network in pathological skin conditions, such as psoriasis or squamous cancer, by their common neurotrophin receptor CD271 has become recently evident. Depending on the specific ligand and co-receptor interacting with it, CD271 mediates various cellular responses in …

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Andrographis paniculata Extract Supports Skin Homeostasis by Enhancing Epidermal Stem Cell Function and Reinforcing Their Extracellular Niche

Roberta Lotti, L. Cattuzzato, David Garandeau, Elisabetta Palazzo et autres

Skin aging is characterized by compromised epidermal homeostasis and dermo-epidermal junction (DEJ) integrity, resulting in reduced stem cell potential and impaired tissue regeneration. This study investigated the effects of Andrographis paniculata extract (APE) on keratinocyte stem cells (KSCs) and DEJ composition in …

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Treatment of pemphigus and other neglected skin conditions with PC111, a human anti-Fas Ligand monoclonal antibody: a potential disease modifier

Roberta Lotti, Antonino Amato, Brydon L. Bennett, Tommaso Zanocco‐Marani et autres

BACKGROUND: Pemphigus vulgaris (PV) is a chronic autoimmune blistering disease with high morbidity and mortality, treated mainly with long-term immunosuppressants. Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) is an acute, life-threatening drug reaction with severe skin and mucosal involvement. No approved therapies currently exist …

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