Amanda Anqueira-González

The role of sensory experience in the maturation of prefrontal cortical circuits

Amanda Anqueira-González, Sarah Canetta

Sensory input during early life is crucial for brain circuitry to be appropriately wired and refined. Foundational studies in the past century established that early sensory input was required for the appropriate development of primary sensory areas. Further investigation in the beginning …

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Peripuberty Is a Sensitive Period for Prefrontal Parvalbumin Interneuron Activity to Impact Adult Cognitive Flexibility

Gabriella M Sahyoun, Trang Dao, Amanda Anqueira-González, Ava Hornblass et autres

INTRODUCTION: Developmental windows in which experiences can elicit long-lasting effects on brain circuitry and behavior are called "sensitive periods" and reflect a state of heightened plasticity. The classic example of a sensitive period comes from studies of sensory systems, like the visual …

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Traumatic Brain Injury–Induced Fear Generalization in Mice Involves Hippocampal Memory Trace Dysfunction and Is Alleviated by (R,S)-Ketamine

Josephine C. McGowan, Liliana Ladner, Claire Shubeck, Juliana Tapia et autres

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Traumatic brain injury-induced fear generalization in mice involves hippocampal memory trace dysfunction and is alleviated by ( R,S )-ketamine

Josephine C. McGowan, Claire Shubeck, Juliana Tapia, Christina T. LaGamma et autres

ABSTRACT INTRODUCTION Traumatic brain injury (TBI) is a debilitating neurological disorder caused by an impact to the head by an outside force. TBI results in persistent cognitive impairments, including fear generalization, the inability to distinguish between aversive and neutral stimuli. The mechanisms …

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Transcriptional Correlates of Chronic Alcohol Neuroadaptation in Drosophila Larvae

Amanda Anqueira-González, Jenny P. Acevedo‐Gonzalez, Airined Montes-Mercado, Claudia Irizarry-Hernández et autres

When presented with the choice, Drosophila melanogaster females will often prefer to lay eggs on food containing a significant amount of alcohol. While, in some cases, this behavioral decision can provide a survival advantage to the developing larvae, it can also lead …

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