Emi Yoshizawa

Gene editing enables non-invasive in vivo PET imaging of human induced pluripotent stem cell-derived liver bud organoids

Candice Ashmore‐Harris, Hiroaki Ayabe, Emi Yoshizawa, Tetsu Arisawa et autres

Human induced pluripotent stem cell (hiPSC)-derived liver cell therapies such as hepatocyte-like cells and liver organoids could provide unlimited therapeutic cells for clinical transplantation, but an inadequate understanding of their in vivo fate impedes translation. Whole body in vivo imaging could enable …

gb, jp, us (code pays fourni par la source)

Defining Lineage-Specific Membrane Fluidity Signatures that Regulate Adhesion Kinetics

Takahisa Matsuzaki, Shinya Matsumoto, Toshiharu Kasai, Emi Yoshizawa et autres

Cellular membrane fluidity is a critical modulator of cell adhesion and migration, prompting us to define the systematic landscape of lineage-specific cellular fluidity throughout differentiation. Here, we have unveiled membrane fluidity landscapes in various lineages ranging from human pluripotency to differentiated progeny: …

jp, us (code pays fourni par la source)

Optimal Hypoxia Regulates Human iPSC-Derived Liver Bud Differentiation through Intercellular TGFB Signaling

Hiroaki Ayabe, Takahisa Anada, Takuo Kamoya, Tomoya Sato et autres

Timely controlled oxygen (O 2 ) delivery is crucial for the developing liver. However, the influence of O 2 on intercellular communication during hepatogenesis is unclear. Using a human induced pluripotent stem cell-derived liver bud (hiPSC-LB) model, we found hypoxia induced with …

jp, us, de (code pays fourni par la source)

Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells

Takanori Takebe, Keisuke Sekine, Masaki Kimura, Emi Yoshizawa et autres

Organoid technology provides a revolutionary paradigm toward therapy but has yet to be applied in humans, mainly because of reproducibility and scalability challenges. Here, we overcome these limitations by evolving a scalable organ bud production platform entirely from human induced pluripotent stem …

us, jp (code pays fourni par la source)

Multilineage communication regulates human liver bud development from pluripotency

J. Gray Camp, Keisuke Sekine, Tobias Gerber, Henry Loeffler‐Wirth et autres

de, jp, au, us (code pays fourni par la source)

Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell-Driven Condensation

Takanori Takebe, Masahiro Enomura, Emi Yoshizawa, Masaki Kimura et autres

jp, us (code pays fourni par la source)

Transient vascularization of transplanted human adult–derived progenitors promotes self-organizing cartilage

Takanori Takebe, Shinji Kobayashi, Hiromu Suzuki, Mitsuru Mizuno et autres

Millions of patients worldwide are affected by craniofacial deformations caused by congenital defects or trauma. Current surgical interventions have limited therapeutic outcomes; therefore, methods that would allow cartilage restoration are of great interest. A number of studies on embryonic limb development have …

jp (code pays fourni par la source)

Self-Formation of Vascularized Hepatic Tissue From Human Adult Hepatocyte

Y. Enomoto, Masahiro Enomura, Takanori Takebe, Y. Mitsuhashi et autres

jp (code pays fourni par la source)

Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant

Takanori Takebe, Ranran Zhang, Hiroyuki Koike, Masaki Kimura et autres

jp (code pays fourni par la source)