Pascal Klöckner

Optimized L1CAM-CAR T cells enhance activity against moderate-antigen-density rhabdomyosarcoma models.

Caroline Piccand, Corentin Gauthier, Pascal Klöckner, Sara G. Danielli et autres

Rhabdomyosarcoma (RMS), the most common pediatric soft tissue sarcoma, remains difficult to treat in relapsed, metastatic, or refractory disease. Chimeric antigen receptor (CAR) T cell therapy has demonstrated promising results in hematological diseases, but its application to solid tumors including RMS is …

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Crowdsourcing enables robust cell annotation for breast cancer pathology

Pascal Klöckner, Melis Erdal Cesur, Bart de Rooij, Zainab Ameziane et autres

The tumor microenvironment (TME) contains important morphological and molecular cues that help determine prognosis and therapeutic responses. Deep learning models can assist pathologists in assessing such biomarkers. However, generating high-quality annotations for computational pathology remains a significant bottleneck due to the level …

ch, nl, tr (code pays fourni par la source)

Crowdsourcing enables robust cell annotation for breast cancer pathology.

Pascal Klöckner, Melis Erdal Cesur, Bart de Rooij, Zainab Ameziane et autres

The tumor microenvironment (TME) contains important morphological and molecular cues that help determine prognosis and therapeutic responses. Deep learning models can assist pathologists in assessing such biomarkers. However, generating high-quality annotations for computational pathology remains a significant bottleneck due to the level …

at, us (code pays fourni par la source)

Leveraging Adversarial Learning for Pathological Fidelity in Virtual Staining

José Alberto Teixeira, Pascal Klöckner, Diana Montezuma, Melis Erdal Cesur et autres

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GANs vs. Diffusion Models for Virtual Staining with the HER2match Dataset

Pascal Klöckner, José Alberto Teixeira, Diana Montezuma, Jaime S. Cardoso et autres

nl, pt, us (code pays fourni par la source)

H&E to IHC virtual staining methods in breast cancer: an overview and benchmarking

Pascal Klöckner, José Alberto Teixeira, Diana Montezuma, João Baptista de Paula Fraga et autres

Immunohistochemistry (IHC) is crucial for the clinical categorisation of breast cancer cases. Deep generative models may offer a cost-effective alternative by virtually generating IHC images from hematoxylin and eosin samples. This review explores the state-of-the-art in virtual staining for breast cancer biomarkers …

nl, pt, us (code pays fourni par la source)

Pro-Resolving Mediators in Rotator Cuff Disease: How Is the Bursa Involved?

Franka Klatte‐Schulz, Nicole Bormann, Aysha Bonell, Jasmin Al-Michref et autres

So far, tendon regeneration has mainly been analyzed independent from its adjacent tissues. However, the subacromial bursa in particular appears to influence the local inflammatory milieu in the shoulder. The resolution of local inflammation in the shoulder tissues is essential for tendon …

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Organisational Climate Fostering Playfulness

Cornelia Gerdenitsch, Daniela Wurhofer, Pascal Klöckner, Simone Kriglstein et autres

Organisations differ in the acceptance of playfulness at the workplace. While some value playful approaches as a means of increasing employees' motivation, others are convinced that playing games is not appropriate in a working context. Depending on whether playful approaches are accepted …

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