David W. Holdsworth

STABILITY 2: A protocol for a randomised trial in orthopaedic surgery to determine whether anterior cruciate ligament (ACL) reconstruction using a patellar or quadriceps tendon autograft with or without lateral extra-articular tenodesis is more effective at reducing the incidence of recurrent instability in young, active athletes

Dianne Bryant, Alan Getgood, James Irrgang, Volker Musahl et autres

INTRODUCTION: Anterior cruciate ligament reconstruction (ACLR) is complicated by high failure rates in young, active individuals, which is associated with worse outcomes and higher rates of osteoarthritis (OA). Failure of ACLR limits activity, reduces quality of life and substantially increases socio-economic costs. …

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Combination antibiotic-loaded poly(ester amide) coatings and induction heating for bacterial killing on metal surfaces

Saman Nadeem, Mónica Vásquez Peña, Chia-Hsin Ho, Avery Gaudreau et autres

Antibiotics were loaded into a poly(ester amide) coating with a T g just above 37 °C. Induction heating of a coated titanium implant triggered localized antibiotic release, leading to synergistic killing of S. aureus biofilms by heat and antibiotics.

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Stress CMR as a measure to separate athletic hearts from early dilated cardiomyopathies

Rojda Ipek, Jennifer L. Holland, Roshan Xavier, Per Arvidsson et autres

Motivation: Exercise-induced cardiac adaptations can manifest as left ventricular (LV) dilatation and mildly reduced LV ejection fraction (LVEF), which makes the differentiation of an athletic heart from early dilated cardiomyopathy (DCM) challenging. This overlap of clinical uncertainty is termed 'grey zone' being …

A novel method to simulate radiographs of 3D printed objects

Maxwell C. Campbell, Steven I. Pollmann, Jaques S. Milner, Emily Lalone et autres

BACKGROUND: 3D printing has a number of applications within medicine and healthcare. In applications involving radiography, the internal infill structure and external geometry of a 3D printed part can produce undesirable artifacts, limiting the full potential of 3D printing as a manufacturing …

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Prototype design of porous Ti6Al4V intraosseous implant for use in mandibular reconstruction

K. Hijazi, Haojie Mao, David W. Holdsworth, S. Jeffrey Dixon et autres

The design of patient-specific implants often requires computer simulations for the characterization of mechanical properties before manufacturing. We previously developed numerical models to predict the mechanical properties of porous Ti6Al4V constructs built using laser powder bed fusion (LPBF). Here, we developed a …

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Non-invasive photon-counting CCTA imaging of severely calcific coronary artery disease: Is ultra-high resolution imaging the solution?

Rafail A. Kotronias, Giovanni De Maria, Cheng Xie, Sheena Thomas et autres

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Design and evaluation of a prototype radio-ultrasound guided system for simultaneous, dual-modality intraoperative localization

Sydney Wilson, Hristo N. Nikolov, Amal Aziz, Aaron Fenster et autres

Due to limitations in individual image guidance modalities, such as gamma probes or ultrasound imaging, up to 25% of patients must undergo a revision surgery following breast-conserving surgery. Although previous studies have shown that hybrid imaging systems combining complementary molecular and anatomical …

Performance evaluation of a miniature 14-channel spectrometer for low-cost qPCR

Tamie L. Poepping, Steven I. Pollmann, Lee D. Sikstrom, David W. Holdsworth

Analytic instrumentation for biomedical research is typically too expensive for low-resource settings, which limits research capacity around the world. However, recent developments in ultra-miniature optical instrumentation provide the opportunity to re-think some types of lab equipment, such as quantitative PCR (qPCR) systems. …

Cost-effective neonatal cerebral oximeter for low-resource settings (Conference Presentation)

Nailin Li, Lee D. Sikstrom, David W. Holdsworth, Mamadou Diop

Mechanical and microstructural properties of additively manufactured porous titanium alloy constructs for orthopaedic and maxillofacial reconstruction

K. Hijazi, Haojie Mao, David W. Holdsworth, S. Jeffrey Dixon et autres

Porous intraosseous implants, fabricated from titanium alloy by selective laser melting (SLM), promote osseointegration and decrease stress shielding. Nevertheless, the application of such constructs in surgery has been restricted due to issues with their structural and mechanical properties. In addition, the flexural …

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Cost-effective spectral quantification of skin tone for improved medical optical instrumentation

Lee D. Sikstrom, Maria Drangova, David W. Holdsworth

Ionospheric vertical TEC measurements using radar observations of Starlink satellites

David W. Holdsworth, Iain M. Reid

There is increasing interest in space domain awareness (SDA) worldwide, motivating the use of non-traditional sensors for space surveillance.One such sensor is the Buckland Park Stratosphere-Troposphere VHF radar, which has demonstrated an ability to detect over 2000 resident space objects (RSO) daily.A …

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