Rebekka Lehmann

Antiseizure medication use in pregnancy and the risk of poor fetal growth in the EURAP international registry: a prospective cohort study

Piero Perucca, Charles Benjamin Malpas, Alexander Berry‐Noronha, Susan Philippa Walker et autres

BACKGROUND: Poor fetal growth is a major cause of perinatal morbidity and mortality and predisposes individuals to chronic diseases in adulthood. Antiseizure medication use in pregnancy has been linked with poor fetal growth, but this association has received little attention and its …

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Cenobamate in adult patients with epilepsy and intellectual disability

David Steinbart, Rebekka Geelhaar, Rebekka Lehmann, Anja Grimmer et autres

OBJECTIVE: In people with intellectual disability (ID), prevalence of epilepsy is up to 50-times higher than in the general population and often difficult to treat. Multiple randomized controlled, observational and retrospective studies have demonstrated favorable efficacy of adjunctive cenobamate (CNB). So far, …

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Non‐discontinuation of antiseizure medication in seizure‐free patients with epilepsy: Reasons and predictors among neurologists and patients

Luise Graf, Jakob I. Doerrfuss, Matthias Wawra, Nicoletta Doerr et autres

OBJECTIVE: This study was undertaken to investigate clinical and psychosocial factors associated with antiseizure medication (ASM) non-discontinuation in seizure-free patients with epilepsy among both neurologists and patients. METHODS: In this cross-sectional study, neurologists documented their recommendations on ASM discontinuation (comprising both complete …

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Risk of Major Congenital Malformations and Exposure to Antiseizure Medication Monotherapy

Dina Battino, Torbjörn Tomson, Erminio Bonizzoni, John J. Craig et autres

Importance: Women with epilepsy (WWE) require treatment with antiseizure medications (ASMs) during pregnancy, which may be associated with an increased risk of major congenital malformations (MCMs) in their offspring. Objective: To investigate the prevalence of MCMs after prenatal exposure to 8 commonly …

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Efficacy and Safety of XEN1101, a Novel Potassium Channel Opener, in Adults With Focal Epilepsy

Jacqueline A. French, Roger J. Porter, Emilio Perucca, Martin J. Brodie et autres

Importance: Many patients with focal epilepsy experience seizures despite treatment with currently available antiseizure medications (ASMs) and may benefit from novel therapeutics. Objective: To evaluate the efficacy and safety of XEN1101, a novel small-molecule selective Kv7.2/Kv7.3 potassium channel opener, in the treatment …

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Driving eligibility following acute symptomatic seizure with structural brain lesion – English Version

Martin Holtkamp, Eva Breuer, Verena Gaus, Rebekka Lehmann et autres

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Driving eligibility following acute symptomatic seizures due to a structural brain lesion – English Version

Martin Holtkamp, Eva Breuer, Verena Gaus, Rebekka Lehmann et autres

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Fahreignung nach akut-symptomatischem Anfall und isoliertem unprovozierten Anfall

Martin Holtkamp, Eva Breuer, Verena Gaus, Rebekka Lehmann et autres

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Fahreignung nach akut-symptomatischem Anfall bei struktureller Hirnläsion

Martin Holtkamp, Eva Breuer, Verena Gaus, Rebekka Lehmann et autres

Zusammenfassung Akut-symptomatische Anfälle gehen oft auf eine frische strukturelle Hirnläsion zurück. Diese Konstellation wird allerdings in den Begutachtungsleitlinien zur Kraftfahreignung nicht thematisiert. Das Risiko späterer unprovozierter Rezidivanfälle nach strukturellem akut-symptomatischem Anfall entspricht statistisch dem Rezidivrisiko nach isoliertem unprovoziertem Anfall (20–40 % in …

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Sleep-Disordered Breathing in REM Sleep Behavior Disorder with or without Parkinson’s Disease

Bernd J. Vorderwülbecke, Rebekka Lehmann, Eva Breuer

REM sleep behavior disorder (RBD) might render patients with Parkinson's disease prone to sleep-disordered breathing. This retrospective polysomonographic study assessed the prevalence of sleep-disordered breathing in 108 consecutive patients with either both Parkinson's disease and RBD (n = 37), Parkinson's disease without …

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