Yangxiao Yu

Thioketal-Mediated Silk Fibroin Nanoparticles with Reactive Oxygen Species-Triggered Structural Disintegration for Site-Specific Anti-Inflammatory Therapy

Yangxiao Yu, Yi Luo, Mengnan Dai, Yiwei Liu et autres

Silk fibroin (SF), a biocompatible natural macromolecule with self-assembly ability, has emerged as a promising drug delivery carrier. However, native SF lacks smart responsiveness. In this study, we introduced thioketal (TK) into SF to engineer an SF-based macromolecular network and further developed …

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Regulation of Mineralization and Compressive Properties in Silk Protein Porous Scaffolds to Enhance Osteogenic Differentiation

Yangxiao Yu, Yao Zhang, Mengnan Dai, Yujing Tian et autres

Abstract Mineralization capacity is an indispensable and critical property for bone tissue engineering (BTE) scaffolds. Silk protein (silk fibroin, SF; silk sericin, SS) possesses satisfactory mineralization potential. In this study, we employed silk protein as the primary material to develop in situ …

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Silk fibroin small-caliber vascular grafts with tunable degradability for differential in situ tissue regeneration and maturation

Yangxiao Yu, Helei Li, Jianmei Xu, Fenglin Dong et autres

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Recent advances and challenges in silk fibroin-based small-caliber vascular grafts: A review

Yangxiao Yu, Jiannan Wang

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Ca2+ induced silk protein hydrogels: structural characteristics, rapid water absorption and anti-compression behavior

Tian Zhang, Meng Li, Jiajun Gong, Yujing Tian et autres

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Bioabsorbable Stent-Covering with Sustained Anticoagulant Activity Fabricated via Alternate Layer-by-Layer Self-Assembly of Heparin and Silk Fibroin

Yangxiao Yu, Mengnan Dai, Meng Li, Guangzhou Song et autres

For severe local vasculopathy, covered stents are considered the major medical devices in interventional therapy due to their function to isolate lesions and deliver drugs. However, commercial stent-coverings have unsatisfactory drug-loading capacity and lack bioactivity. Silk fibroin (SF) possesses excellent biocompatibility, biodegradability, …

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Sericin/silk fibroin composite aerogel for hemostatic application

Meng Li, Jiajun Gong, Yangxiao Yu, Jianmei Xu et autres

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Tailoring silk-based covering material with matched mechanical properties for vascular tissue engineering

Yangxiao Yu, Guangzhou Song, Mengnan Dai, Peixuan Li et autres

Vascular covered stents play a significant therapeutic role in cardiovascular diseases. However, the poor compliance and biological inertness of commercial materials cause post-implantation complications. Silk fibroin (SF), as a biomaterial, possesses satisfactory hemocompatibility and tissue compatibility. In this study, we developed a …

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Potential Applications of ROS-Responsive Silk Fibroin Materials in Smart Drug Delivery Systems

Peixuan Li, Yangxiao Yu, Song Hui, Mengnan Dai et autres

Silk fibroin (SF) is a promising drug carrier because of its unique macromolecular structure and excellent biocompatibility and biodegradability. In this study, we developed a responsive SF material by introducing reactive oxygen species (ROS)-cleavable thioketal (TK) between the SF macromolecular chains. TK …

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Tailoring Silk Film with Matched Mechanical Properties: A Potential Covering Material for Vascular Tissue Engineering

Yangxiao Yu, Guangzhou Song, Mengnan Dai, Caiyu Zhou et autres

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Effect of degumming degree on the structure and tensile properties of RSF/RSS composite films prepared by one-step extraction

Meng Li, Wei Tian, Yangxiao Yu, Yao Zhang et autres

Abstract Regenerated silk fibroin (RSF) and regenerated sericin (RSS) have attracted much attention for tissue engineering due to excellent biocompatibility and controllable degradation. However, pure RSF films prepared by existing methods are brittle, which limits applications in the field of high-strength and/or …

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Silk Fibroin/Silk Braiding Fabric Composite Grafts via Layer-by-Layer Self-Assembly: Water Permeability and Cytocompatibility

Yangxiao Yu, Guangzhou Song, Mengnan Dai, Lingpeng Meng et autres

Stent grafts play an important role in sealing vessel perforations, ruptures or aneurysms for remodeling vascular access, but maintaining long-term patency remains a major challenge after implantation. Silk fibroin (SF) is an ideal vascular graft material with excellent biocompatibility and physicochemical properties. …

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