Menglei Zhu

Large language model trained on clinical oncology data predicts cancer progression

Menglei Zhu, Hui Lin, Jue Jiang, Abbas J. Jinia et autres

Subspecialty knowledge barriers have limited the adoption of large language models (LLMs) in oncology. We introduce Woollie, an open-source, oncology-specific LLM trained on real-world data from Memorial Sloan Kettering Cancer Center (MSK) across lung, breast, prostate, pancreatic, and colorectal cancers, with external …

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Abstract LB-255: Prognostic role of neuroendocrine differentiation marker in prostate adenocarcinoma

Menglei Zhu, Wei Chen, Michael J. Glover, Eswar Shankar et autres

Abstract Neuroendocrine differentiation (NED) has been recognized in prostatic adenocarcinomas. NED prostate adenocarcinoma represent a subset of aggressive tumor phenotypes which may be associated with therapeutic resistance and dismal outcome. Genomic and transcriptomic studies have suggested that there is marked intra-tumor heterogeneity …

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Writing the Genome: Are We Ready?

Menglei Zhu, Christine L. Schmotzer

Since the completion of the Human Genome Project (HGP-read), improvements of sequencing technology, dramatic reductions in sequencing cost, and importantly, progress in understanding of the function of the human genome have been continual. Recent advances in sequencing-based technologies and DNA-editing methods [e.g., …

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FUNCTION OF ANDROGEN RECEPTOR IN PROSTATE CANCER EPITHELIAL MESENCHYMAL TRANSITION AND MICROTUBULE TARGETING

Menglei Zhu

Prostate cancer is the most frequently diagnosed non-skin cancer and the third leading cause of cancer mortality among men in the US. Androgens are functionally required for the normal growth of the prostate gland and play a critical role in prostate tumor …

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Androgen receptor and growth factor signaling cross-talk in prostate cancer cells

Menglei Zhu, Natasha Kyprianou

Androgens promote the growth and differentiation of prostate cells through ligand activation of the androgen receptor (AR). Sensitization of the androgenic response by multifunctional growth factor signaling pathways is one of the mechanisms via which AR contributes to the emergence of androgen-independent …

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Prestin up-regulation in chronic salicylate (aspirin) administration: An implication of functional dependence of prestin expression

Ning Yu, Menglei Zhu, Ben L. Johnson, Ying‐Peng Liu et autres

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Prestin is expressed on the whole outer hair cell basolateral surface

Ning Yu, Menglei Zhu, Hong-Bo Zhao

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