Jimmy J.L.L. Akkermans

USP24 is a cross-reactive DUB targeting MOV10 to regulate IFN-I production

Rishov Mukhopadhyay, Simeon D. Draganov, Timo Oosenbrug, Jimmy J.L.L. Akkermans et autres

The type I Interferon (IFN-I)-induced ubiquitin-like modifier Interferon-Stimulated Gene 15 (ISG15) plays a crucial role in the innate immune response against viral infections. ISG15 is conjugated to target proteins by an enzymatic cascade, called ISGylation. While ubiquitin-specific protease 18 (USP18) serves as …

nl, cn, gb, de, es (code pays fourni par la source)

Salmonella exploits USP32 to coordinate Rab14 and Rab11 recycling pathways for intracellular survival

Ayşegül Sapmaz, Sabina Y. van der Zanden, Jimmy J.L.L. Akkermans, Loréline Menager et autres

SUMMARY Many intracellular bacterial pathogens establish membrane-bound niches derived from host material to survive and replicate within host cells. These compartments are carved through subversion of host intracellular trafficking pathways to modulate the composition of the vacuolar membrane. Although recycling-associated small Rab …

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Advancing the Exploration of the Ubiquitin‐like Protein FUBI with Synthetic Chemical Tools

Francesca D’Amico, Cami Talavera Ormeño, Shivanganie Poeran, Jimmy J.L.L. Akkermans et autres

The Ubiquitin-like protein FUBI is encoded in humans by the FAU gene, whose down-regulation in prostate, ovarian and breast cancer is significantly associated with poor prognosis. Despite its implications in disease progression, the regulatory mechanisms orchestrated by FUBI remain elusive. To address …

nl (code pays fourni par la source)

Multi-omics analyses of cancer-linked clinical salmonellae reveal bacterial-induced host metabolic shift and mTOR-dependent cell transformation

Virginie Stévenin, Claudia E. Coipan, Janneke W. Duijster, Daphne M. van Elsland et autres

Salmonellae are associated epidemiologically and experimentally with colon cancer. To understand how Salmonella induces cell transformation, we performed multi-omics and phenotypic analyses of Salmonella clinical strains isolated from patients later diagnosed with colon cancer (case strains) and control strains from patients without …

nl (code pays fourni par la source)

Systems mapping of bidirectional endosomal transport through the crowded cell

Marlieke L.M. Jongsma, Nina Bakker, Lenard M. Voortman, Roman I. Koning et autres

and become competent for endosomal capture and minus-end movement in collaboration with membrane-associated Rab7-RILP. We show that endosomes surf over the ER through the crowded cell and move bidirectionally under the control of MAPs for motor activation and through motor replacement and …

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USP24 is an ISG15 cross-reactive deubiquitinase that mediates IFN-I production by de-ISGylating the RNA helicase MOV10

Rishov Mukhopadhyay, Simeon D. Draganov, Jimmy J.L.L. Akkermans, Marjolein Kikkert et autres

ABSTRACT The interferon-stimulated gene 15 (ISG15) is a ubiquitin-like modifier induced by type I Interferon (IFN-I) and plays a crucial role in the innate immune response against viral infections. ISG15 is conjugated to target proteins by an enzymatic cascade through a process …

nl, gb, de, es (code pays fourni par la source)

Author response: The ORP9-ORP11 dimer promotes sphingomyelin synthesis

Birol Cabukusta, Shalom Borst Pauwels, Jimmy J.L.L. Akkermans, Niek Blomberg et autres

nl (code pays fourni par la source)

The ORP9-ORP11 dimer promotes sphingomyelin synthesis

Birol Cabukusta, Shalom Borst Pauwels, Jimmy J.L.L. Akkermans, Niek Blomberg et autres

Numerous lipids are heterogeneously distributed among organelles. Most lipid trafficking between organelles is achieved by a group of lipid transfer proteins (LTPs) that carry lipids using their hydrophobic cavities. The human genome encodes many intracellular LTPs responsible for lipid trafficking and the …

nl (code pays fourni par la source)

Author response: The ORP9-ORP11 dimer promotes sphingomyelin synthesis

Birol Cabukusta, Shalom Borst Pauwels, Jimmy J.L.L. Akkermans, Niek Blomberg et autres

Numerous lipids are heterogeneously distributed among organelles. Most lipid trafficking between organelles is achieved by a group of lipid transfer proteins (LTPs) that carry lipids using their hydrophobic cavities. The human genome encodes many intracellular LTPs responsible for lipid trafficking and the …

nl (code pays fourni par la source)

The ORP9-ORP11 dimer promotes sphingomyelin synthesis

Birol Cabukusta, Shalom Borst Pauwels, Jimmy J.L.L. Akkermans, Niek Blomberg et autres

Abstract Numerous lipids are heterogeneously distributed among organelles. Most lipid trafficking between organelles is achieved by a group of lipid transfer proteins (LTPs) that carry lipids using their hydrophobic cavities. The human genome encodes many intracellular LTPs responsible for lipid trafficking and …

nl (code pays fourni par la source)

Reviewer #2 (Public Review): The ORP9-ORP11 dimer promotes sphingomyelin synthesis

Birol Cabukusta, Shalom Borst Pauwels, Jimmy J.L.L. Akkermans, Niek Blomberg et autres

Numerous lipids are heterogeneously distributed among organelles. Most lipid trafficking between organelles is achieved by a group of lipid transfer proteins (LTPs) that carry lipids using their hydrophobic cavities. The human genome encodes many intracellular LTPs responsible for lipid trafficking and the …

USP16 is an ISG15 cross-reactive deubiquitinase that targets pro-ISG15 and ISGylated proteins involved in metabolism

Adán Pinto-Fernández, Dennis Flierman, Jimmy J.L.L. Akkermans, Darragh Patrick O'Brien et autres

Interferon-induced ubiquitin (Ub)-like modifier ISG15 covalently modifies host and viral proteins to restrict viral infections. Its function is counteracted by the canonical deISGylase USP18 or Ub-specific protease 18. Notwithstanding indications for the existence of other ISG15 cross-reactive proteases, these remain to be …

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