Accès ouvert
2025
article
OpenAlex
Fumiaki Sato, Yusuke Nagano, Daiki Tachibana, Hiroko Ikeda et autres
Abstract Background Obsessive-compulsive disorder (OCD) is a psychiatric disorder characterized by the presence of obsessions and compulsions, leading to significant impairment in social and occupational functioning. The current first-line treatment for OCD involves the use of selective serotonin reuptake inhibitors (SSRIs). However, …
jp
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Kohei Ota, Hirotaka Nagai, Wenran Qiu, Io Horikawa et autres
Chronic stress causes depressed mood and cognitive deficits and predisposes to mental illness. Brain metabolic changes are linked to stress pathology, but their molecular mechanism and functional significance remain unknown. In this study, we exposed C57BL/6N male mice to chronic social defeat …
jp, gb, nz
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Hirotaka Nagai, Midori Nagai, Chisato Numa, Tomomi Yamashita et autres
Chronic social stress induces emotional and cognitive disturbances and is a risk for mental illness. Reduced neuronal activity in the medial prefrontal cortex (mPFC) underlies these behavioral abnormalities. However, the subcellular origin and process of this neuronal change remain elusive. Here we …
jp, us, gb
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Chisato Numa, Hirotaka Nagai, Midori Nagai, Tomomi Yamashita et autres
Chronic social stress induces neuronal dysfunctions in the medial prefrontal cortex (mPFC) for emotional and cognitive disturbances. However, the subcellular mechanism remains elusive. Here we examined ultrastructural and multi-omics changes in the mPFC in a mouse model of social defeat stress. Acute …
jp, us, gb
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Hirotaka Nagai, Midori Nagai, Chisato Numa, Kohei Ota et autres
Excessive or chronic social stress induces emotional and cognitive disturbances and precipitates mental illness. Altered neuronal morphology and functions in the medial prefrontal cortex (mPFC) underlie these behavioral abnormalities. However, its subcellular mechanisms remain elusive. Here we examined ultrastructural and multi-omics changes …
jp, us
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Jacqueline Palace, Dean M. Wingerchuk, Kazuo Fujihara, Achim Berthele et autres
BACKGROUND: Antibodies to the aquaporin-4 (AQP4) water channel in neuromyelitis optica spectrum disorder (NMOSD) are reported to trigger the complement cascade, which is implicated in astrocyte damage and subsequent neuronal injury. The PREVENT study demonstrated that the terminal complement inhibitor eculizumab reduces …
gb, us, jp, de, es, kr, tr, ru, my, tw
(code pays fourni par la source)