Yang Wan

Successful allogeneic hematopoietic stem cell transplantation in children with myeloid malignancies secondary to GATA2 deficiency using decitabine-containing busulfan conditioning

Yuanyuan Ren, Ranran Zhang, X Chen, Xiaoyan Zhang et autres

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Clinical Phenotype, Molecular Architecture, and Survival Follow-Up in NRAS- and KRAS-Mutated Juvenile Myelomonocytic Leukemia

Bang Zhang, Chenmeng Liu, Xiaolan Li, Yang Wan et autres

Background: Juvenile myelomonocytic leukemia (JMML) is a rare RAS/MAPK-driven pediatric myelodysplastic/myeloproliferative neoplasm. The phenotype and survival relevance of NRAS/KRAS alterations remain difficult to interpret because of co-mutations, evolving sequencing, incomplete germline confirmation, and post-diagnostic HSCT. Methods: We retrospectively reviewed 34 children with …

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Genomic Landscape and Clinical Outcomes of Advanced Pediatric Myelodysplastic Syndromes

Chenmeng Liu, X Wang, Yunlong Chen, Yang Wan et autres

OBJECTIVES: Pediatric myelodysplastic syndromes (MDS) differ from adult MDS, and their genetic basis is poorly understood. This study characterizes the genomic features and clinical outcomes of advanced pediatric MDS. METHODS: In this retrospective study, next-generation sequencing was performed on 63 pediatric patients …

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Relapse risk and outcome of discontinuing asparaginase in children with acute lymphoblastic leukemia

Xingchen Wang, Chenmeng Liu, Yunlong Chen, Junxia Wang et autres

Asparaginase is a cornerstone of pediatric acute lymphoblastic leukemia (ALL) therapy, but treatment discontinuation due to toxicity may increase relapse risk and compromise outcomes. We retrospectively analyzed 993 pediatric ALL patients (aged 1.0-17.9 years) treated under the CCCG-ALL-2015 protocol from May 2015 …

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Low hematologic event-free survival with age in shwachman-diamond syndrome

Kasiani Myers, Jean Donadieu, Benjamin A. Goldberg, Manon Delafoy et autres

Abstract Background: Shwachman Diamond syndrome (SDS) is characterized by bone marrow failure (BMF) and an increased risk of myeloid and lymphoid malignancies. Prognosis of myelodysplasia (MDS) or acute myeloid leukemia (AML) is poor, so regular surveillance is recommended to screen for early …

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Protein and gene levels of DNAJC21 and RNF5 as drug targets for immune thrombocytopenia: optimized post-GWAS insights

Xiaoli Li, Jun Li, Yang Lan, Yang Wan et autres

Objectives Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by antibody-mediated platelet (PLT) destruction. Its clinical manifestations are highly heterogeneous, and the unclear pathogenesis poses significant challenges for effective treatment. The limited efficacy of current therapies underscores the need for novel therapeutic …

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[Progress in diagnosis and treatment of RAS-related autoimmune lymphoproliferative disorder].

Jianing Ren, Yang Wan, Xiaofan Zhu

. Its main pathological feature is immune dysregulation-induced hematologic destruction, presenting with symptoms resembling autoimmune diseases. RALD exhibits significant clinical heterogeneity, with manifestations including autoimmune phenomena, hepatosplenomegaly, lymphadenopathy, monocytosis, and increased susceptibility to infections. Owing to its rarity and its unclear nature, …

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Development and validation of nomograms for survival prediction in Fanconi anemia

Yiman Gao, Hongyu Li, Wenbin An, Li Zhang et autres

To The Editor: 1. INTRODUCTION Fanconi anemia (FA) is a hereditary disorder characterized by genomic instability and increased sensitivity to DNA crosslinking agents.1 FA is typically diagnosed in childhood, with an average age at diagnosis of 7 years.2 Mutations in any of …

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Development and Validation of a Prediction Model for Severe Pre‐Engraftment Syndrome During the Treatment of Unrelated Umbilical Cord Blood Transplantation in Pediatric Patients

Shiyuan Wang, Lipeng Liu, Yuanyuan Ren, Xia Chen et autres

BACKGROUND: Pre-engraftment syndrome (PES) is a common immune response during the early stages of umbilical cord blood transplantation (UCBT), but the severity classification of PES remains uncertain. OBJECTIVES: To develop and validate a predictive model for PES severity in pediatric patients receiving …

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Efficacy and safety of primary letermovir prophylaxis for cytomegalovirus infection in paediatric patients undergoing allogeneic transplantation: a single-centre, retrospective, real-world analysis

Xin Wang, Chaoqian Jiang, Lipeng Liu, Xia Chen et autres

Background: Cytomegalovirus (CMV) infection is a common and life-threatening complication following allogeneic haematopoietic stem cell transplantation (allo-HSCT). Letermovir (LET) has been the standard prophylaxis for adult recipients, but studies in children remain limited. Methods: We retrospectively analyzed children with or without LET …

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Efficacy and prognostic assessment of chemotherapy-bridged transplantation in pediatric patients with advanced myelodysplastic syndromes

Xingchen Wang, Chenmeng Liu, Yunlong Chen, Yang Wan et autres

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The impact of SARS-CoV-2 infection on immunity reconstitution among pediatric patients after allogeneic hematopoietic stem cell transplantation: a propensity score-matched analysis

Xin Wang, LiPeng Liu, Luyang Zhang, Yue Shang et autres

Background Immunity reconstitution (IR) is crucial for pediatric patients undergoing hematopoietic stem cell transplantation (HSCT), but the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on lymphocyte subsets post-transplant remains unclear. Therefore, we assessed immune cell dynamics in children after …

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