T.H.P. Hanahoe

Comparison of Histamine and 5-Hydroxytryptamine Content and Secretion in Rat Mast Cells Isolated from Different Anatomical Locations

Wendy M. Purcell, Damien Cohen, T.H.P. Hanahoe

Rat mast cells, isolated from different anatomical locations, were found to exhibit heterogeneity with respect to histamine and 5-hydroxytryptamine (5-HT) content. Unlike peritoneal mast cells, those derived by enzymatic digestion of rat lung and mesentery tissues contained amounts of 5-HT in excess …

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Distribution of 3 H-Dextran in Two Colonies of Wistar Rats after Intravenous Injection

T.H.P. Hanahoe, J.D. Wright

The rate of elimination of 3H-dextran from the blood after intravenous administration was found to be considerably faster in rats which react to dextran with an anaphylactoid reaction than in rats which do not. Correspondingly, the rate of appearance of 3H-dextran in …

Contribution of Post-Secretory Mechanisms to the Observed Pattern of Histamine and 5-Hydroxytryptamine Secretion from Peritoneal Rat Mast Cells in Response to Compound 48/80

Wendy M. Purcell, Damien Cohen, T.H.P. Hanahoe

Compound 48/80 induces a greater percentage release of histamine than 5-HT from purified peritoneal rat mast cells such that the log-concentration effect curves diverge. Mast cells were shown to remove histamine and 5-HT applied exogenously, although uptake of 5-HT was in preference …

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Genetic Susceptibility of Rats to Some Forms of Delayed Hypersensitivity

F.B. De Brito, T.H.P. Hanahoe

The F1 generation, produced by mating Wistar rats from the Tuck colony which react to dextran (R rats) with Wistar rats from the NELP colony which do not react (NR rats) all responded to dextran with an anaphylactoid oedema reaction, and developed …

Susceptibility of Two Colonies of Wistar Rats to Inflammation, with Particular Reference to Delayed Hypersensitivity

F.B. De Brito, T.H.P. Hanahoe

Two colonies of Wistar rats were tested for their abilities to produce delayed hypersensitivity reactions and other forms of inflammation. Tuck rats, which respond to dextran with an anaphylactoid reaction, produced delayed reactions to tuberculin protein and to ovalbumin in Freund's incomplete …

Contents, Vol. 90, 1989

Akira Fujioka, Carlo Pincelli, Akihiko Hashimoto, Kimie Fukuyama et autres

News Items

Madeleine Ennis, Cemre Robinson, Colin T. Dollery, Francis B. Casey et autres

Author Index

Akira Fujioka, Carlo Pincelli, Akihiko Hashimoto, Kimie Fukuyama et autres

Heparin and Acute Inflammation in the Rat

T.H.P. Hanahoe, Derek R. Jones

The subcutaneous injection of heparin into the dorsal cervical region of rats 30 min before the intrapedal administration of carrageenin significantly impaired the local inflammatory reaction from 2 h through to 6 h. This observation implies that the release of endogenous heparins …

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The Effects of Cyclophosphamide on Delayed Hypersensitivity in Rats

F.B. De Brito, T.H.P. Hanahoe

Pretreatment of Tuck Wistar rats with cyclophosphamide (100 mg kg-1) intraperitoneally prevents the development of adjuvant-induced arthritis, experimental allergic encephalomyelitis and the delayed skin reactions after ovalbumin and Freund's incomplete adjuvant. The resistance of these rats to these stimuli is similar to …

A Possible Link between the Ability of Rat Isolated Peritoneal Mast Cells to Release Histamine when Challenged with Dextran and the Proteins in Their Plasma Membranes

Russell I. Ludowyke, Geoffrey B. West, James R. Harris, T.H.P. Hanahoe

The plasma membranes of peritoneal mast cells from rats specifically bred for resistance to the dextran anaphylactoid reaction contain a polypeptide of molecular weight about 74,000 daltons which is deficient in those from rats which show the reaction. It is suggested that …

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Delayed Hypersensitivity Reactions in Rats and Their Response to Clinical Dextran

F.B. De Brito, T.H.P. Hanahoe, Pranali Nitin Shah, Geoffrey B. West

Four colonies of rats were tested for their ability to produce adjuvant-induced arthritis, oxazolone contact hypersensitivity and the dextran anaphylactoid reaction. Tuck Wistar and Hooded Lister rats, both of which respond to dextran, showed disseminated inflammatory lesions after adjuvant and exhibited oxazolone …