Pei‐Ching Chang

Attenuation of Cuproptosis Through Histone Deacetylase Inhibition: A Novel Strategy for Alleviating Acute Lung Injury

H.-C. Shen, Wei‐Kuang Yu, C.-Y. Sun, Wan‐Chin Chen et autres

Abstract Background: Acute respiratory distress syndrome/ acute lung injury (ARDS/ALI) are significant causes of respiratory failure, associated with high mortality and often underrecognized. The pathophysiology of ALI is complex, with growing evidence indicating the involvement of regulated cell death (RCD) mechanisms in …

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Development of KSHV vaccine platforms and chimeric MHV68-K-K8.1 glycoprotein for evaluating the in vivo immunogenicity and efficacy of KSHV vaccine candidates

Wan-Shan Yang, Do-Kyun Kim, Soowon Kang, Chih‐Jen Lai et autres

ABSTRACT Kaposi’s sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 is an etiological agent of Kaposi’s Sarcoma, multicentric Castleman’s disease, and primary effusion lymphoma. Considering the high seroprevalence reaching up to 80% in sub-Saharan Africa, an effective vaccine is crucial for preventing KSHV infection. However, …

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Regions Important for Hemagglutination Activity and Serotypes of Avibacterium paragallinarum HMTp210 Protein

K.-P. Li, Duen-Huey Tan, Shan-Chia Ou, Yiyi Gong et autres

Regiones importantes para la actividad de hemaglutinación y serotipos de la proteína HMTp210 de Avibacterium paragallinarum. La bacteria Avibacterium paragallinarum es un patógeno respiratorio importante de los pollos domésticos. Avibacterium paragallinarum se subtipificó en tres serogrupos y nueve serovares de acuerdo con …

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NLRP12 is an innate immune checkpoint for repressing IFN signatures and attenuating lupus nephritis progression

Yen‐Po Tsao, Fang-Yu Tseng, Chih-Wei Chao, Ming‐Han Chen et autres

Mep50 is essential for embryonic development in medaka fish

Qiting Yao, Shi Duan, Qing Yang, Xiaoqin Ma et autres

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IFN‐stimulated metabolite transporter ENT3 facilitates viral genome release

Yu‐Ting Hsieh, Tsung‐Lin Tsai, Shen‐Yan Huang, Jian‐Wen Heng et autres

An increasing amount of evidence emphasizes the role of metabolic reprogramming in immune cells to fight infections. However, little is known about the regulation of metabolite transporters that facilitate and support metabolic demands. In this study, we found that the expression of …

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Protein Arginine Methyltransferase 5 Is Necessary for Embryonic Development in Medaka Oryzias latipes

Xiaoting Liang, Shi Duan, Qing Yang, Xiaoqin Ma et autres

Protein arginine methyltransferase 5 (Prmt5), conserved from yeast to humans, catalyzes arginine’s dimethylation in proteins. Prmt5 is necessary for embryonic development in mice because it maintains embryonic stem cells. However, the embryos of zebrafish (Danio rerio) remain viable with a deficiency in …

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SUMO Modification of Histone Demethylase KDM4A in Kaposi’s Sarcoma-Associated Herpesvirus-Induced Primary Effusion Lymphoma

Wayne Wei Yeh, Yin‐Quan Chen, Wan-Shan Yang, Yung-Chih Hong et autres

PEL is an aggressive and untreatable B-cell lymphoma caused by KSHV infection. Therefore, new therapeutic approaches for PEL need to be investigated. Since simultaneous induction of KSHV reactivation and apoptosis can directly kill PEL cells, they have been applied in the treatment …

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A novel REST-regulated lncRNA PCAT-NE1 induces neuroendocrine differentiation in castration-resistant prostate cancer

Ching-Hsin Chang, Wayne Wei Yeh, Ting-Yu Cheng, Yun-Li Luo et autres

Abstract Background Lineage plasticity is recognized as a treatment-induced resistance mechanism in prostate cancer (PCa) and contributes to the development of neuroendocrine prostate cancer (NEPC), a lethal variant of castration-resistant prostate cancer (CRPC), that is increasing in the era of second-generation anti-hormonal …

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Equilibrative Nucleoside Transporter 3 is an IFN-stimulated Gene that Facilitates Viral Genome Release

Yu‐Ting Hsieh, Tsung‐Lin Tsai, Chia-Chun Tu, Shen-Yan Huang et autres

Abstract An increasing body of evidence emphasizes the role of metabolic reprogramming in immune cells to fight off infections. However, little is known about the regulation of metabolite transporters that facilitate and support metabolic demands. In this study, we found that equilibrative …

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Long non-coding RNA KIKAT/LINC01061 as a novel epigenetic regulator that relocates KDM4A on chromatin and modulates viral reactivation

Wan-Shan Yang, Wayne Wei Yeh, Mel Campbell, Lung Chang et autres

KDM4A is a histone lysine demethylase that has been described as an oncogene in various types of cancer. The importance of KDM4A-mediated epigenetic regulation in tumorigenesis is just emerging. Here, by using Kaposi's sarcoma associated herpesvirus (KSHV) as a screening model, we …

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Relationship Between the Serotypes and Hemagglutinin Gene Sequences of Avibacterium paragallinarum

Duen-Huey Tan, Yan-xuan Gong, Shan-Chia Ou, Cheng‐Yao Yang et autres

Avibacterium paragallinarum has been subtyped into three serogroups (A, B, and C) and nine serovars (A-1, A-2, A-3, A-4, B-1, C-1, C-2, C-3, and C-4) according to the Page and Kume schemes. Both schemes use the hemagglutination inhibition test for serotyping. However, …

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