Ching-Hsin Chang

Nutraceutical Evaluation of Trigonelline's Therapeutic Potential by Targeting Bladder Cancer Stem Cells and Cancer-Associated Fibroblasts via Downregulation of TGFβ3/GLI2/YAP1 Signaling Hub

Chien‐Chang Kao, Jing-Wen Shih, Huong Thi Luu Kim Huynh, Ching-Hsin Chang et autres

experiments demonstrated that TGN effectively inhibited BLCA cell proliferation, colony formation, and tumorspheroid growth while significantly enhancing cisplatin sensitivity in resistant cell lines. Notably, TGN reduced the transformation of fibroblasts into cancer-associated fibroblasts (CAFs) through the downregulation of α-SMA and FAP (Fibroblast …

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Perspectives on Pathological Crosstalk between Malocclusion and Multi-organ Systems: The Hidden Face of an Iceberg

TP Chaturvedi, Ching-Hsin Chang, Prathap Somu, Navneet Kumar Dubey et autres

Malocclusion is a dental disorder that has often been overlooked in physiological studies. It is defined as any malrelationship of dental arches with or without aberration in the teeth developmental disorder, which alters functions like mastication, swallowing, speech, etc. Mounting evidence implies …

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High-Intensity Focused Ultrasound for Grade Group 1–3 Localized Prostate Cancer: Oncologic and Safety Outcomes in a Taiwanese Cohort

Chi-Tai Li, Tien-Mei Chen, Ching-Hsin Chang

Background: Prostate cancer commonly affects older men. There is increasing interest in minimally invasive treatment options such as high-intensity focused ultrasound, which provides oncologic control with reduced side effects and functional preservation. We evaluated the oncologic and functional outcomes of whole-gland high-intensity …

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Epigenetic regulation of neuroendocrine prostate cancer

Tze-Yun Hu, Yung-Chih Hong, Po‐An Chen, Ching-Hsin Chang et autres

Neuroendocrine prostate cancer (PCa), an aggressive subtype of PCa, can arise de novo or from pre-existing castration-resistant PCa, especially after treatment with new-generation androgen receptor signaling inhibitors (ARSIs); thus, it is a major cause of resistance to ARSIs. Lineage plasticity drives the …

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Prostate health index density aids the diagnosis of prostate cancer detected using magnetic resonance imaging targeted prostate biopsy in Taiwanese multicenter study

Ching-Hsin Chang, Ping-Hsuan Yu, Po‐Fan Hsieh, Jian‐Hua Hong et autres

BACKGROUND: Multiparametric magnetic resonance imaging (mpMRI) followed by MRI-targeted prostate biopsy is the current standard for diagnosing prostate cancer (PCa). However, studies evaluating the value of biomarkers, including prostate health index (PHI) and its derivatives using this method are limited. We aimed …

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Prostate health index density in the diagnosis of clinically significant prostate cancer in equivocal magnetic resonance imaging of the prostate in the Taiwan community

Ching-Hsin Chang

REST-repressed lncRNA LINC01801 induces neuroendocrine differentiation in prostate cancer via transcriptional activation of autophagy.

Ching-Hsin Chang, Ting-Yu Cheng, Wayne Wei Yeh, Yun-Li Luo et autres

The association between REST reduction and the development of neuroendocrine prostate cancer (NEPC), a novel drug-resistant and lethal variant of castration-resistant prostate cancer (CRPC), is well established. To better understand the mechanisms underlying this process, we aimed to identify REST-repressed long noncoding …

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Single-cell analysis of castration-resistant prostate cancers to identify potential biomarkers for diagnosis and prognosis of neuroendocrine prostate cancer.

Yung-Chih Hong, Tze-Yun Hu, Chi‐Hsin Hsu, Wayne Wei Yeh et autres

The high heterogeneity and low percentage of neuroendocrine cells in prostate cancer limit the utility of traditional bulk RNA sequencing and even single-cell RNA sequencing to find better biomarkers for early diagnosis and stratification. Re-clustering of specific cell-type holds great promise for …

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A novel REST-regulated lncRNA PCAT-NE1 induces neuroendocrine differentiation in castration-resistant prostate cancer

Ching-Hsin Chang, Wayne Wei Yeh, Ting-Yu Cheng, Yun-Li Luo et autres

Abstract Background Lineage plasticity is recognized as a treatment-induced resistance mechanism in prostate cancer (PCa) and contributes to the development of neuroendocrine prostate cancer (NEPC), a lethal variant of castration-resistant prostate cancer (CRPC), that is increasing in the era of second-generation anti-hormonal …

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Non-Muscular Invasive Bladder Cancer: Re-envisioning Therapeutic Journey from Traditional to Regenerative Interventions

Kuan-Wei Shih, Wei-Chieh Chen, Ching-Hsin Chang, Ting-En Tai et autres

Non-muscular invasive bladder cancer (NMIBC) is one of the most common cancer and major cause of economical and health burden in developed countries. Progression of NMIBC has been characterized as low-grade (Ta) and high grade (carcinoma in situ and T1). The current …

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Long Non-Coding RNA PCAT-NE1 Activates Autophagy via miR-6889-3p-Regulated VPS13A to Induce Neuroendocrine Differentiation

Ching-Hsin Chang, Wayne Wei Yeh, Ting-Yu Cheng, Yun-Li Luo et autres

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Safety and effectiveness of high-power thulium laser enucleation of the prostate in patients with glands larger than 80 mL

Ching-Hsin Chang, Tzu‐Ping Lin, Jung-Yao Huang

BACKGROUND: The efficacy of thulium laser prostate enucleation (ThuLEP) for large prostates is unclear. This study aimed to explore the expanded utility of 150-200-W ThuLEP by studying patients with a large prostate (> 80 mL). METHODS: We retrospectively reviewed records of 125 …

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