Wahib Ghanem

Contribution of Virtual Reality to Surgical Decision-Making for Evaluating Vascular Contraindications in Malignant Head and Neck Tumors

Axel Munoglu, O. Choussy, M. Lesnik, Wahib Ghanem et autres

Introduction Virtual reality (VR) is increasingly used in medicine for preoperative planning. This study evaluated the role of 3D-VR reconstruction in assessing contraindications and surgical failure risks in head and neck cancers (HNC) with peri-carotid involvement. Methods In this retrospective, single-center study …

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Physical activity in people affected by head and neck cancers: gender-specific barriers and preferences—ORLAPA survey results

Joey Martin, Timothée Marchal, Nolween Badier, Carole Bouleuc et autres

PURPOSE: People with head and neck cancers (HNCs) often experience deconditioning, nutritional challenges, and low adherence to physical activity (PA) guidelines. While gender influences PA behaviors in other cancers, data among HNC survivors remain limited. We investigated gender-specific differences in PA preferences, …

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Clinical landscape for patients with head and neck cancers enrolled in phase I trials at a tertiary referral center

Daria Maria Filippini, R. Sanchez, Etienne Bastien, Nicolas Jacquin et autres

Background: Recent advances in understanding the biology of cancer have resulted in an extensive armamentarium of new therapeutic agents, most often tested on various tumor types at the earliest stages of drug development. However, the clinical impact of these therapies on patients …

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Deciphering molecular relapse and intra-tumor heterogeneity in non-metastatic resectable head and neck squamous cell carcinoma using circulating tumor DNA

Grégoire Marret, Constance Lamy, Sophie Vacher, Luc Cabel et autres

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Biomarkers and Prognostic Stratification of Squamous Cell Carcinoma of the Oral Cavity in Young Adults: How to Personalize Therapeutic Management?

Antoine Dubray‐Vautrin, Guillaume Rougier, Christophe Le Tourneau, Wahib Ghanem et autres

Squamous cell carcinomas of the oral cavity in young adults represent a heterogeneous entity. New prognostic biomarkers are described in the literature. The aim of this review was to identify emerging biomarkers and prognostic stratification factors of young population. Clinical, biological, microbiological, …

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Lymph Node Evolution in Eyelid and Orbit Squamous Cell Carcinomas

Emilien Chebib, Guillaume Rougier, Antoine Dubray‐Vautrin, Joey Martin et autres

OBJECTIVES: To describe a large cohort of eyelid and periorbital SCCs, to compare the location of the tumor and of the pathological lymph nodes, and to analyze the risk factors for lymph node involvement among tumor characteristics. METHODS: All patients managed inside …

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“Ice cream cone” design of forearm free flap for orbital exenteration reconstruction

Joey Martin, Antoine Dubray-Vautrin, Baptiste Sabran, Robin Baudouin et autres

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Abstract 1620: Multiregion spatial sequencing of early-stage head and neck squamous cell carcinoma revealed theranostic intratumor heterogeneity

Grégoire Marret, Sophie Vacher, Constance Lamy, Ladidi Ahmanache et autres

Abstract Introduction: Head and neck squamous cell carcinoma (HNSCC) is characterized by substantial intratumor heterogeneity (ITH) at the molecular level that may foster tumor evolution, adaptation, and therapeutic failure. Personalized-medicine strategies mostly rely on single tumor-biopsy samples which might not capture the …

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Upper Aerodigestive Tract Endoscopy Combining Rigid Laryngoscopy and Flexible Endoscopy

Antoine Dubray‐Vautrin, Christian Chappey, Rabah Taouachi, Wahib Ghanem et autres

Upper Aerodigestive Tract Endoscopy (UATE) is recommended for initial examination of head and neck squamous cell carcinomas. Reducing delay of initial examination must be a challenge to manage head and neck cancers. We hereby describe the technic combining UATE and flexible endoscopy …

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A new device for managing refractory epistaxis in ICU patients with COVID19

O. Choussy, Nicolas Viault, Wahib Ghanem, Antoine Dubray‐Vautrin et autres

Five Key points COVID 19 treatment generate nose bleeding Covid 19 treatment necessitate prone position Nasal packing is useful but sometimes insufficient CAVI-T is a new treatment of epistaxis CAVI-T is especially adapted to COVID patient in prone position due to its …

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Is Primary Poorly Differentiated Sarcomatoid Malignancy of the Parotid Gland Sarcomatoid Undifferentiated/Dedifferentiated Melanoma? Report of Three Unusual Cases Diagnosed by Fine-Needle Aspiration Combined with Histological, Immunohistochemical, and Molecular Analyses

Jerzy Klijanienko, Julien Masliah‐Planchon, O. Choussy, Guillaume Rougier et autres

INTRODUCTION: Poorly differentiated primary sarcomatoid parotid malignancies are extremely rare. These tumors have not been consistently studied by morphology, immunohistochemistry, or molecular techniques. CASE PRESENTATION: We report three unusual cases of parotid gland poorly-differentiated sarcomatoid malignancy investigated by fine-needle aspiration and studied …

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Head and neck INI1-deficient carcinoma without primary: a case report

Antoine Dubray‐Vautrin, Wahib Ghanem, Laurence Bozec, Julie Gonin et autres

BACKGROUND: SMARCB1, also known as INI1, is a member of a large protein complex involved in chromatin remodeling and thus the regulation of gene expression. It is located on chromosome 22q11.2. SMARCB1 tumors have been found in various locations, including the sinonasal …

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