Jiang Yao

Cloud-enabled hybrid structural equation modeling and artificial neural network framework for energy-efficient green buildings

Jiang Yao, Ge Haixiang, Chu Yanping, Zou Qizhi et autres

Rapid urbanization and the growth in demand for sustainable infrastructure have made energy efficiency in the built environment a world priority. Nonetheless, the inherent gap between predictions and actual operational use is a fundamental challenge, as linear models, almost exclusively, often fail …

cn, sy, gb, sa (code pays fourni par la source)

The global epidemiology, risk factors, and mortality prediction of nocardiosis: an easily missed opportunistic infection

Bingqian Du, Ziyu Song, Zhiqiang Ren, Jirao Shen et autres

This study was to comprehensively investigate the epidemiology of nocardiosis worldwide and develop an interpretable machine learning (ML) model to predict mortality in patients with nocardiosis. The PubMed and Web of Science databases were searched for the literature review using the keywords: …

cn (code pays fourni par la source)

Nitric Oxide Contributes to the Pathogenesis of Nocardia farcinica Infection in BALB/c Mice and Alveolar MH-S Macrophages

Jiang Yao, Lichao Han, Jirao Shen, Bingqian Du et autres

Nocardia, a rare but life-threatening pathogen, can invade multiple tissues and organs, such as lungs, brain, skin and soft tissue. In this study, we determined whether nitric oxide (NO) contributes to the severity of experimental pulmonary nocardiosis. BALB/c mice with or without …

cn (code pays fourni par la source)

Intratracheal Aerosolization of Nocardia farcinica in Mice Optimizes Bacterial Distribution and Enhances Pathogenicity Compared to Intranasal Inoculation and Intratracheal Instillation

Bingqian Du, Ziyu Song, Jirao Shen, Jiang Yao et autres

Nocardia, an easily missed but potentially fatal opportunistic pathogen, can lead to serious infections like lung and brain abscesses. Intranasal inoculation (IN) is the traditional approach for constructing a Nocardia-induced pneumonia mice model, while it usually only results in limited local bacterial …

cn (code pays fourni par la source)

Infection route influence the consequences of Nocardia farcinica infection in BALB/c mice

Jirao Shen, Lichao Han, Jiang Yao, Xiaotong Qiu et autres

Nocardia , a rare but potentially fatal pathogen, can induce systemic infections with diverse manifestations. This study aimed to investigate the tissue and organ damage caused by Nocardia farcinica ( N. farcinica ) in mice via different infection routes, evaluate the resulting …

cn (code pays fourni par la source)

Activation of NF-κB/MAPK signaling and induction of apoptosis by salicylate synthase NbtS in Nocardia farcinica promotes neuroinflammation development

Jirao Shen, Xing zhao Ji, Lichao Han, Jiang Yao et autres

ABSTRACT Nocardia farcinica can cause a rare, yet potentially fatal, central nervous system infection. NbtS protein may be a key virulence factor in N. farcinica infection of the brain. In this study, we investigated the function of the virulence-associated factor NbtS in …

cn (code pays fourni par la source)

Nocardia implantans sp. nov. isolated from a patient with pulmonary infection

Yihe Liang, Shuai Xu, Jiang Yao, Jirao Shen et autres

TwoGram-stain-positive and rod-shaped actinomycetes (strains CDC186 T and CDC192) were isolated from sputum samples of a patient in Chongqing, PR China, and were investigated to determine their taxonomic status. The results of phylogenetic analysis based on the 16S rRNA gene indicated that …

cn (code pays fourni par la source)

Capture of armA by a novel ISCR element, ISCR28

Min Yuan, Lu Nie, Zhenzhou Huang, Shuai Xu et autres

ISCR28 is a fully functional and active member of the IS91-like family of insertion sequences. ISCR28 is 1,708-bp long and contains a 1,293-bp long putative open reading frame that codes a transposase. Sixty ISCR28-containing sequences from GenBank generated 27 non-repeat genetic contexts, …

cn (code pays fourni par la source)

Development of a recombinase-aided amplification assay for rapid detection of the human pathogen Nocardia farcinca

Fang Li, Shuai Xu, Ruihuan Wang, Lichao Han et autres

Abstract Nocardia farcinica, one of the most common etiological pathogens of nocardiosis in pulmonary infection, usually causes severe disseminated diseases in immunocompromised individuals. To date, there is a lack of rapid and reliable diagnostic tools for the detection of N. farcinica in …

cn, tw (code pays fourni par la source)

Accurate, Sensitive, and Rapid Detection of Pseudomonas aeruginosa Based on CRISPR/Cas12b with One Fluid-Handling Step

Xiaotong Qiu, Xueping Liu, Ruixue Wang, Xiao Ma et autres

This study reports a P. aeruginosa CRISPR-top assay which can precisely identify P. aeruginosa using nucleic acids from pure cultures or clinical samples in one pot with one fluid-handling step. The P. aeruginosa CRISPR-top reaction is suitable for on-site testing, and its …

cn (code pays fourni par la source)

Immunoprotective Analysis of the NFA49590 Protein from Nocardia farcinica IFM 10152 Demonstrates Its Potential as a Vaccine Candidate

Lichao Han, Xingzhao Ji, Caixin Yang, Shuo Zhao et autres

Nocardia is emerging as a serious and easily neglected pathogen in clinical practice with multidrug resistance that extends the treatment period for months or even years. This has led to the investigation of a vaccine approach to prevent Nocardia infections. However, studies …

cn (code pays fourni par la source)

Three novel Cas12a orthologs with robust DNA cleavage activity suitable for nucleic acid detection

Xueping Liu, Xiaotong Qiu, Lichao Han, Yue Yuan et autres

cn (code pays fourni par la source)