Taise Vitor

PET/CT WITH 68GA-FAPI46 FOR THE DETECTION OF PRIMARY AND METASTATIC LESIONS IN PATIENTS WITH DIFFERENT TYPES OF CANCER. INITIAL EXPERIENCE

Lilian Yuri Itaya Yamaga, Gustavo Borges da Silva Teles, Durval C. B. Santos, Òren Smaletz et autres

Fibroblast activation protein (FAP), a transmembrane glycoprotein, is over expressed by cancer-associated fibroblasts in the tumor microenvironment. Radiolabeled fibroblast activation protein inhibitors (FAPI) are currently being investigated for PET imaging. To evaluate the diagnostic efficacy of PET/CT with fibroblast activation protein inhibitor …

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Implementation of positron emission tomography radiopharmaceuticals labeled with Gallium-68 in a hospital radiopharmacy: experience with more than 7,500 patients

Lilian Yuri Itaya Yamaga, Marycel Rosa Felisa Figols de Barboza, Luciana Malavolta, Leonardo Lima Fuscaldi et autres

Highlights ■ In-house 68Ga radiopharmaceutical synthesis under GMP in a tertiary hospital radiopharmacy. ■ Over 7,500 patients underwent imaging with [68Ga]Ga- DOTATATE and [68Ga]Ga-PSMA-11. ■ This is the first radiopharmacy in Brazil to introduce [68Ga] Ga-DOTA-UBI, and [68Ga]Ga-FAPi-46. ABSTRACT In this study, …

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AUTOMATED SYNTHESIS AND IN VITRO STUDIES OF [68GA]GA-FAPI-46 IN HOSPITAL RADIOPHARMACY

Leonardo Lima Fuscaldi, Paloma Caiado Lupinari, Karen Alessandra Kazumi Sato, Ana Cláudia Camargo Miranda et autres

Early evidence appointed fibroblast activation protein (FAP), a type II transmembrane serine protease, as highly expressed in the stroma of various tumor entities, designating FAP as the next target for cancer studies in nuclear medicine. Several radiolabeled fibroblast activation protein inhibitors (FAPI) …

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Comparative analysis of somatostatin analog uptake between successfully irradiated and non-irradiated meningiomas

Guilherme de Carvalho Campos Neto, Edson Amaro, Suzana Mária Fleury Malheiros, Bruna Letícia Ferrari et autres

OBJECTIVE: To evaluate whether there is a significant difference in somatostatin analog uptake in meningiomas treated or not with radiation therapy. METHODS: A cross-sectional study was performed comparing measurements of somatostatin analog (68Ga-DOTATATE) uptake in two independent groups of ten patients each …

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Virtual Rehabilitation in Parkinson Disease

Juliana M. P. Toldo, Michelly Arjona, Guilherme C. Campos Neto, Taise Vitor et autres

OBJECTIVE: The aim of the study was to verify the effect of a virtual rehabilitation protocol for patients with Parkinson disease, primarily assessing striatal dopamine transporters and secondarily motor symptoms and quality of life. DESIGN: Nineteen patients with Parkinson disease underwent an …

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Kinetic modeling of 68Ga-PSMA-11 and validation of simplified methods for quantification in primary prostate cancer patients

Anna Ringheim, Guilherme de Carvalho Campos Neto, Udunna Anazodo, Lumeng Cui et autres

Abstract Background The positron emission tomography (PET) ligand 68Ga-Glu-urea-Lys(Ahx)-HBED-CC (68Ga-PSMA-11) targets the prostate-specific membrane antigen (PSMA), upregulated in prostate cancer cells. Although 68Ga-PSMA-11 PET is widely used in research and clinical practice, full kinetic modeling has not yet been reported nor have …

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Impaired brain dopamine transporter in chemobrain patients submitted to brain SPECT imaging using the technetium-99m labeled tracer TRODAT-1

Taise Vitor, Elisa Harumi Kozasa, Rodrigo A. Bressan, Shirley Silva Lacerda et autres

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Pharmacokinetic modeling of [68Ga]PSMA-11 in primary prostate cancer patients

Anna Ringheim, Guilherme de Carvalho Campos Neto, Marcelo Livorsi da Cunha, Taise Vitor et autres

15 patients underwent a 60-minute dynamic [68Ga]PSMA-11 PET scan (patient 101P had its scan interrupted at 40 min) in list-mode with the field of view over the pelvic area. PET data were reconstructed with a 3D-Ordered-Subsets Expectation Maximization (OSEM) algorithm (3 iteration, …

Pharmacokinetic modeling of 68Ga-PSMA-11 in primary prostate cancer patients

Anna Ringheim, Guilherme de Carvalho Campos Neto, Udunna Anazodo, Lumeng Cui et autres

15 patients underwent a 60-minute dynamic 68Ga-PSMA-11 PET scan (patient 101P had its scan interrupted at 40 min) in list-mode with the field of view over the pelvic area. PET data were reconstructed with a 3D-Ordered-Subsets Expectation Maximization (OSEM) algorithm (3 iteration, …

Reproducibility of standardized uptake values of same-day randomized 68Ga-PSMA-11 PET/CT and PET/MR scans in recurrent prostate cancer patients

Anna Ringheim, Guilherme de Carvalho Campos Neto, Karine Minaif Martins, Taise Vitor et autres

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Incidental detection of probable meningioma in brain scintigraphy using 99mTc-TRODAT-1

Taise Vitor, Guilherme Campos Carvalho Neto, Solange Amorim Nogueira, Jairo Wagner et autres

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PET/MRI: a novel hybrid imaging technique. Major clinical indications and preliminary experience in Brazil

Taise Vitor, Karine Minaif Martins, Tudor M. Ionescu, Marcelo Livorsi da Cunha et autres

In recent years, medical imaging with hybrid techniques has widely accepted and employed in clinical routine. PET/MRI offers significant advantages, including excellent contrast and resolution and reduced ionizing radiation, as compared to well-established PET/CT. Therefore, PET/MRI is a promising modality for oncologic …

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