Michael Hauser

Editorial Expression of Concern: Purification and biochemical characterization of Hel a 6, a cross-reactive pectate lyase allergen from Sunflower (Helianthus annuus L.) pollen

Nandini Ghosh, Gaurab Sircar, Claudia Asam, Martin Wolf et autres

Editorial Expression of Concern to: Scientific Reports https://doi.org/10.1038/s41598-020-77247-z , published online 19 November 2020

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EAACI Molecular Allergology User's Guide 2.0

Stephanie Dramburg, Christiane Hilger, Alexandra F. Santos, Leticia de las Vecillas et autres

Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE-mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend …

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Mycobacterium avium Complex Infections: Detailed Phenotypic and Functional Immunological Work-Up Is Required despite Genetic Analyses

Bernhard Kratzer, Katharina Grabmeier‐Pfistershammer, Doris Trapin, Ulrike Körmöczi et autres

INTRODUCTION: Cervical scrofulous lymphadenitis due to Mycobacterium avium complex (MAC) in immunocompetent adults is a rare disease. The presence of MAC infections demands meticulous clinical evaluation of patients along with detailed phenotypic and functional evaluation of their immune system including next-generation sequencing …

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The nanotopography of SiO 2 particles impacts the selectivity and 3D fold of bound allergens

Robert Mills-Goodlet, Litty Johnson, Isabel J. Hoppe, Christof Regl et autres

nanoparticles influenced the 3D fold of the protein, resulting in at least partial unfolding. Consequently, this conformational change influenced the allergenic response, as observed by mediator release assays employing the sera of patients and immune effector cells. For an in-depth understanding of …

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Chemical modification of ragweed extract results in an increased safety profile while maintaining immunogenicity

Sara Huber, Hanneke P. M. van der Kleij, Sabrina Wildner, Martin Wolf et autres

Chemical modification of ragweed extract results in an increased safety profile while maintaining immunogenicityTo the Editor, Short or common ragweed (Ambrosia artemisiifolia), belonging to the plant family of Asteraceae, is an annual weed with pollination peak levels in late summer.Epidemiological studies revealed …

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Purification and biochemical characterization of Hel a 6, a cross-reactive pectate lyase allergen from Sunflower (Helianthus annuus L.) pollen

Nandini Ghosh, Gaurab Sircar, Claudia Asam, Martin Wolf et autres

Sunflower pollen was reported to contain respiratory allergens responsible for occupational allergy and pollinosis. The present study describes the comprehensive characterization of a major sunflower allergen Hel a 6. Natural Hel a 6 was purified from sunflower pollen by anion exchange and …

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Hydrogen/deuterium exchange memory NMR reveals structural epitopes involved in IgE cross-reactivity of allergenic lipid transfer proteins

Martina Di Muzio, Sabrina Wildner, Sara Huber, Michael Hauser et autres

Identification of antibody-binding epitopes is crucial to understand immunological mechanisms. It is of particular interest for allergenic proteins with high cross-reactivity as observed in the lipid transfer protein (LTP) syndrome, which is characterized by severe allergic reactions. Art v 3, a pollen …

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Retinoic acid‐loading of the major birch pollen allergen Bet v 1 may improve specific allergen immunotherapy: In silico, in vitro and in vivo data in BALB/c mice

Karin Hufnagl, Sheriene Moussa Afify, Nina Kaegi-Braun, Stefanie Wagner et autres

More than twenty different isoforms of Bet v 1, the major birch pollen allergen, have been identified, sharing an amino acid sequence identity of 95% and an almost identical tertiary structure.1 Despite their structural similarities, the isoforms display remarkable different immunogenic properties …

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Weed pollen allergens

Michael Hauser, Gabriele Gadermaier, Sabrina Wildner, Lisa Pointner et autres

Pollen originating from weeds is one of the most important sources of allergenic proteins. The term weed is not a botanical classification but is used to describe a highly heterogeneous group of plants lacking appreciable economic or esthetic value. Presently, 47 weed …

Laser‐facilitated epicutaneous immunotherapy with depigmented house dust mite extract alleviates allergic responses in a mouse model of allergic lung inflammation

Evgeniia Korotchenko, Raquel Moya, Sandra Scheiblhofer, Isabella Anna Joubert et autres

BACKGROUND: Skin-based immunotherapy of type 1 allergies has recently been re-investigated as an alternative for subcutaneous injections. In the current study, we employed a mouse model of house dust mite (HDM)-induced lung inflammation to explore the potential of laser-facilitated epicutaneous allergen-specific treatment. …

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El centro vacío del populismo actual: la constitución antinómica del líder populista

Michael Hauser

Con los populismos de Donald Trump y Vladimir Putin como puntos de referencia, este artículo analiza las inconsistencias compartidas por las ideologías y estrategias populistas actuales. Se sostiene que el populismo actual está relacionado con el ser social multitudinario (multitudinal social being), …

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Harmonization of the Genetic Code Effectively Enhances the Recombinant Production of the Major Birch Pollen Allergen Bet v 1

Claudia Asam, Anargyros Roulias, María Alejandra Parigiani, Astrid Haab et autres

BACKGROUND: Enhancing the quality and yield of protein production in heterologous expression systems is an important issue for developing new biopharmaceuticals. It has been shown that the dynamics of protein folding is influenced by codon frequencies. As codon usage frequencies are species …

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