Accès ouvert
2026
article
OpenAlex
Maria Aliotti Lippolis, Sabine Koinig, Christian Dorfer, Luca Conci et autres
Abstract Background Neuro-ophthalmological disturbances present frequently in pediatric posterior fossa (PF) tumors, contributing significantly to morbidity. This study evaluates their prevalence, risk factors, and outcomes in affected children. Methods This retrospective study analyzed 119 children with PF tumors treated over a decade …
at
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Hannah Schned, Maria Aliotti Lippolis, Cora Hedrich, Natalia Stepien et autres
Abstract Background Bevacizumab (BVZ) is widely used in patients with central nervous system (CNS) tumors. Due to its potential to impair wound healing, a minimum interval of 28 days between BVZ administration and surgery - both before and after the procedure - …
at
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Cora Hedrich, Priya Patel, Lukas Haider, Tracey Taylor et autres
Background: Children with craniopharyngiomas (CPs) typically suffer from a life-long chronic disease. The younger the child, the more vulnerable the maturing brain is to invasive therapies such as surgery or radiotherapy. Therefore, treatment modalities facilitating avoidance or delay of invasive therapies are …
at, ca, gb, es
(code pays fourni par la source)
Accès ouvert
2024
conference-abstract
OpenAlex
Hannah Schned, Christine Haberler, Andreas Peyrl, Amedeo A. Azizi et autres
Abstract BACKGROUND Improvement of molecular diagnostics has led to significant changes in the categorization of paediatric brain tumours, unveiling novel tumour entities in the latest 2021 WHO classification of central nervous system (CNS) tumours (5th edition), particularly within the group of rare …
at, dk, de, nl, cz, fr
(code pays fourni par la source)
Accès ouvert
2024
conference-abstract
OpenAlex
Natalia Stepien, Daniel Senfter, Julia Freund, Sarah Machreich et autres
Abstract BACKGROUND The introduction of tumour classification by analysis of DNA methylation has changed the landscape of paediatric neuro-oncology. With the launch of Oxford Nanopore sequencing, generation of sequencing data is possible in real-time, including information on base-modifications. Diverse classification tools for …
at, de, nl
(code pays fourni par la source)
Accès ouvert
2024
conference-abstract
OpenAlex
Cora Hedrich, Priya Patel, Lukas Haider, Tracey Taylor et autres
Abstract BACKGROUND Craniopharyngiomas (CP) is a life-long chronic disease predominantly affecting young children. Consequently, the developing brain is particularly sensitive to therapies such as surgery or radiotherapy. Hence, therapies allowing to avoid or delay intensive therapies provide substantial benefit. Intracystic injection of …
at, ca, gb, es
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Anna Cho, Maria Aliotti Lippolis, Johannes Herta, Muhammet Doğan et autres
PURPOSE: Various surgical nuances of the telovelar approach have been suggested. The necessity of removing the posterior arch of C1 to accomplish optimal tumor exposure is still debated. Therefore, we report on our experience and technical details of the fourth ventricular tumor …
at
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Natalia Stepien, Lisa Mayr, Cora Hedrich, Maria Aliotti Lippolis et autres
Abstract Activation of FGF signaling has been described for at least 3% of pediatric solid tumors including pediatric gliomas. Therapeutic actionability of FGF signaling activations, however, remains challenging. Here, we report on three patients with FGFR activation treated with erdafitinib, originally approved …
at, us
(code pays fourni par la source)
Accès ouvert
2022
conference-abstract
OpenAlex
Maria Aliotti Lippolis, Sabine Koinig, Amedeo A. Azizi, Christian Dorfer et autres
Abstract BACKGROUND Medulloblastoma represents the most common malignant pediatric brain tumor. Ophthalmic complications are possible sequelae. METHODS Pediatric medulloblastoma (MB) patients treated at the Medical University of Vienna from January 2012 to August 2021 were analyzed and their last ophthalmic assessment was …
at
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Accès ouvert
2022
article
OpenAlex
Irene Slavc, Lisa Mayr, Natalia Stepien, Johannes Gojo et autres
Medulloblastoma (MB) recurrence is usually incurable despite intensive therapy including high-dose chemotherapy. An evolving alternative approach to conventional chemotherapy aims at interfering with tumor angiogenesis at different levels. We report on a novel combinatorial metronomic antiangiogenic approach. The study is a retrospective …
at, se, dk, fr, de, nl
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Andreas Peyrl, Natalia Stepien, Lisa Mayr, Amedeo A. Azizi et autres
Abstract BACKGROUND: Malignant brain tumors carry a high risk for leptomeningeal dissemination, but the CSF compartment is often not affected by systemic therapy. Intraventricular therapy via an Ommaya reservoir is one possibility to increase the cytotoxic drug concentration in the CSF. Unfortunately, …
at
(code pays fourni par la source)