Allison M. Schwalb

Small-molecule modulation of β-arrestins

Alem W. Kahsai, Natalia Pakharukova, Henry Y. Kwon, Kunal S. Shah et autres

. Although GPCR pharmacology has advanced to target orthosteric and allosteric sites, as well as G proteins and GPCR kinases, direct chemical tools to modulate β-arrestin activities have remained conspicuously absent. Here we report the identification of small-molecule inhibitors that selectively target …

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Selective impact on regulatory T cells with sustained functional phenotypes by the interleukin-2 mutein VIS171 in a nonhuman primate model

Davide Schiliró, Matt Tunbridge, Nolan J. Brown, Joshua Lopez et autres

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Cryopreserved Skin Transplantation in a Nonhuman Primate Model

Meghan Hu, Rafaela Belloni, Joseph M. Ladowski, Davide Schiliró et autres

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Use of the Frailty “Timed Up and Go” Test to Predict Perioperative Complications in Patients Undergoing Gynecologic Cancer Surgery

Mary Katherine Anastasio, Allison M. Schwalb, Katherine N. Penvose, Donna Niedzwiecki et autres

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Rhesus D Prophylaxis: When and Why We Give Rhesus D Immunoglobulin

Allison M. Schwalb, Jerome J. Federspiel, Sarah K. Dotters‐Katz, Jeffrey A. Kuller et autres

Importance Hemolytic disease of the fetus and newborn (HDFN) is caused by maternal alloantibodies to fetal red blood cells and is associated with significant fetal and neonatal morbidity and mortality. Rhesus D antigen (RhD)–mediated HDFN is the only preventable cause of alloimmunization …

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Small-molecule modulation of β-arrestins

Alem W. Kahsai, Natalia Pakharukova, Henry Y. Kwon, Kunal S. Shah et autres

β-arrestins are multifunctional regulators of G protein-coupled receptor (GPCR) signaling, orchestrating diverse downstream signaling events and physiological responses across the vast GPCR superfamily. While GPCR pharmacology has advanced to target orthosteric and allosteric sites, as well as G proteins and GRKs, comparable …

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Immunoproteasome inhibition reduces donor specific antibody production and cardiac allograft vasculopathy in a mouse heart transplantation model

Allison M. Schwalb, Imran J. Anwar, Isabel DeLaura, Joseph M. Ladowski et autres

Objective Cardiac Allograft Vasculopathy (CAV), a process of vascular damage accelerated by antibody-mediated rejection (AMR), is one of the leading causes of cardiac transplant failure. Proteasome inhibitors (PIs) are utilized to treat AMR, however PI-associated toxicity limits their therapeutic utility. Novel immunoproteasome …

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SURG-07. QUANTIFYING THE RISK OF SHORT TERM SEIZURES FOLLOWING LASER INTERSTITIAL THERMAL THERAPY

Ethan Srinivasan, Ann Marie Flusché, Aden Haskell-Mendoza, Joshua Woo et autres

Abstract BACKGROUND Tumor-related epilepsy is a common sequela of both primary and metastatic brain tumors, as well as radiation necrosis (RN). Laser interstitial thermal therapy (LITT) is an effective option for lesional cytoreduction but induces transient peritumoral edema that typically resolves within …

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Combinatorial Checkpoint Blockade and Laser Interstitial Thermal Therapy: A Single Center Study

Aden Haskell-Mendoza, Lucas P. Wachsmuth, Ethan Srinivasan, Joshua Jackson et autres

INTRODUCTION: Immune checkpoint blockade (ICB) has gained acceptance as a life-extending therapy in a variety of solid tumor types. For patients with brain metastases, combination stereotactic radiosurgery (SRS) and ICB remains an area of clinical equipoise. Similarly, for recurrent or difficult-to-access intracranial …

Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin

Alem W. Kahsai, Kunal S. Shah, Paul J. Shim, Mason Lee et autres

β-arrestins are multivalent adaptor proteins that bind active phosphorylated G protein-coupled receptors (GPCRs) to inhibit G protein signaling, mediate receptor internalization, and initiate alternative signaling events. β-arrestins link agonist-stimulated GPCRs to downstream signaling partners, such as the c-Raf-MEK1-ERK1/2 cascade leading to ERK1/2 …

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Risk of Tract Seeding Following Laser Interstitial Thermal Therapy for Brain Tumors

Aden Haskell-Mendoza, Ethan Srinivasan, Emily Lerner, Ryan Edwards et autres

BACKGROUND: The management of intracranial oncological disease remains a significant challenge despite advances in systemic cancer therapy. Laser interstitial thermal therapy (LITT) represents a novel treatment for local control of brain tumors through photocoagulation with a stereotactically implanted laser fiber. Because the …

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Commentary: Laser Interstitial Thermal Therapy for First-Line Treatment of Surgically Accessible Recurrent Glioblastoma: Outcomes Compared With a Surgical Cohort

Allison M. Schwalb, Ethan Srinivasan, Peter E. Fecci

LITT is an increasingly used minimally invasive surgery in neuro-oncology. Current literature has demonstrated its safety and efficacy in treating primary brain tumors, brain metastases, and radiation necrosis, particularly in the context of those poorly suited for open resection. The paper entitled …

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