Esther Mundwiler

Complement C1s deficiency in a male Caucasian patient with systemic lupus erythematosus: a case report

Jessica S. Kleer, Lillemor Skattum, Denise Dubler, Ingeborg Fischer et autres

Deficiencies of the early complement components of the classical pathway (CP) are well-documented in association with systemic lupus erythematosus (SLE) or SLE-like syndromes and severe pyogenic infections. Among these, complete C1s deficiency has been reported in nine cases so far. Here, we …

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Prevalence of markers of beta cell autoimmunity and thyroid disease in children with coeliac disease

Corinne Légeret, Alexander Kutz, Brunner Jessica, Esther Mundwiler et autres

BACKGROUND: Over the last decades, the prevalence of coeliac disease (CD), an autoimmune disorder, rose to 1-2%. Whether patients with CD have higher risk of developing other autoimmune disorders such as type 1 diabetes, Hashimoto thyroiditis, or Graves` disease remains unclear. AIM: …

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Can Treatment of Sudden Speech Impairment Be Life-Saving?

Eduardo Nava, Luca Bernasconi, Esther Mundwiler, Sandra Bigi

Background/Purpose: Pediatric anti-NMDA receptor encephalitis is a rare and life-threatening disease. Timely diagnosis and treatment initiation directly influences outcome. Therefore, a high level of suspicion—particularly in mild new focal neurological deficits—is of utmost importance to prevent neurological sequelae. Case Presentation: We report …

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Diagnostic relevance of free light chains in cerebrospinal fluid – The hyperbolic reference range for reliable data interpretation in quotient diagrams

Hansotto Reiber, David Zeman, Pavlína Kušnierová, Esther Mundwiler et autres

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Variable and inaccurate serum IgG4 levels resulting from lack of standardization in IgG subclass assay calibration

Luca Bernasconi, Esther Mundwiler, Stephan Regenass, Vincent Aubert et autres

Background The quantification of serum IgG4 is commonly performed during the diagnostic workup of IgG4-related diseases (IgG4-RD). According to recent literature, IgG4 values above 1.35 g/L are characteristic of IgG4-RD and support its diagnosis at initial presentation. The purpose of this study …

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Comparison of Five TSH-Receptor Antibody Assays in Graves’ disease: results from an observational pilot study

Tristan Struja, Rebecca Jutzi, Noemi Imahorn, Marina Kaeslin et autres

BACKGROUND: Early diagnosis and relapse prediction in Graves' disease influences treatment. We assessed the abilities of four TSH-receptor antibody tests [TRAb] and one cyclic adenosine monophosphate bioassay to predict relapse of Graves' disease. METHODS: Observational study investigating patients presenting with Graves' disease …

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Diagnostic Accuracy of Basal Cortisol Level to Predict Adrenal Insufficiency in Cosyntropin Testing: Results from an Observational Cohort Study with 804 Patients

Tristan Struja, Leonie Briner, Aline Meier, Alexander Kutz et autres

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External validation of the GREAT score to predict relapse risk in Graves’ disease: results from a multicenter, retrospective study with 741 patients

Tristan Struja, Marina Kaeslin, Fabienne Boesiger, Rebecca Jutzi et autres

Context First-line treatment in Graves’ disease is often done with antithyroid agents (ATD), but relapse rates remain high making definite treatment necessary. Predictors for relapse risk help guiding initial treatment decisions. Objective We aimed to externally validate the prognostic accuracy of the …

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