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Profil bibliographique

Richard J. Schimmel

Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.

53Publications signalées
953Citations signalées
1Affiliations récentes

Les institutions déclarées

Les domaines associés

Adipose Tissue and MetabolismPharmacological Effects and AssaysMuscle metabolism and nutritionReceptor Mechanisms and SignalingAdenosine and Purinergic Signaling

Les publications récentes

2005 article OpenAlex

Stimulus Dependent Redistribution of Membrane Raft Cholesterol in Human Platelets

Kathleen Boesze‐Battaglia, Richard J. Schimmel, Cheryl Gretzula

Abstract Cell membranes provide a requisite dynamic interface to facilitate communication between the extracellular environment and the intracellular milieu. These membranes contain proteins that span and/or are loosely associated with the lipid bilayer. The organization of lipids and proteins components into membrane …

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0 citations Macromolecular Symposia
Accès ouvert 1999 article OpenAlex

Collagen-stimulated unidirectional translocation of cholesterol in human platelet membranes

Kathleen Boesze‐Battaglia, Richard J. Schimmel

When human platelets are stimulated with collagen or thrombin, the asymmetric distribution of membrane lipids is disrupted as phosphatidylserine and phosphatidylethanolamine translocate from the inner monolayer to the outer monolayer. Coincident with the stimulus-dependent rearrangement of membrane phospholipids is a rapid redistribution …

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4 citations Journal of Experimental Biology
1997 article OpenAlex

Cell Membrane Lipid Composition and Distribution: Implications for Cell Function and Lessons Learned From Photoreceptors and Platelets

Kathleen Boesze‐Battaglia, Richard J. Schimmel

Photoreceptor rod cells and blood platelets are remarkably different, yet both illustrate a similar phenomenon. Both are strongly affected by membrane cholesterol, and the distribution of cholesterol in the membranes of both cell types is determined by the lipid composition within the …

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159 citations Journal of Experimental Biology
1997 article OpenAlex

Cholesterol enhances the adhesion of human platelets to fibrinogen: studies using a novel fluorescence based assay

Richard J. Schimmel, Purvin Shah, Madeline Fenner, Kathleen Boesze‐Battaglia

This communication reports investigations on the effect of platelet cholesterol content on adhesion of platelets to a fibrinogen coated surface. The adhesion of platelets stimulated with thrombin or ADP was dramatically increased when the platelet cholesterol content was enriched by incubation with …

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1 citation Platelets
1996 article OpenAlex

Cholesterol Redistribution within Human Platelet Plasma Membrane: Evidence for a Stimulus-Dependent Event

Kathleen Boesze‐Battaglia, Spenser T. Clayton, Richard J. Schimmel

The fluorescent analog NBD-phosphatidylethanolamine and the analogs of cholesterol NBD-cholesterol and cholestatrienol were used to study the distribution of these lipids within the plasma membrane bilayer of human platelets. The probes were incorporated into platelets using phosphatidylcholine donor vesicles. The distribution of …

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34 citations Biochemistry
1995 article OpenAlex

Dissociation of increases in intracellular calcium and aldosterone production induced by angiotensin II (AII): evidence for regulation by distinct AII receptor subtypes or isomorphs.

John F. Kocsis, Richard J. Schimmel, Patrick J. McIlroy, Rocco V. Carsia

In mammalian zona glomerulosa cells, angiotensin II (AII)-induced increases in intracellular Ca2+ ([Ca2+]i) and AII-induced aldosterone production seem to be inextricably linked. However, in avian adrenal steroidogenic (adrenocortical) cells studied thus far, inducible aldosterone production seems to be insensitive to alterations in …

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14 citations Endocrinology

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