G Pastore

Unexpectedly competent immune response to SARS-CoV-2 vaccination in Rett syndrome

Ludovica Soldateschi, Silvia Leoncini, Fabio Fiorino, Simone Lucchesi et autres

Rett syndrome (RTT) is a rare neurodevelopmental disorder of genetic origin characterized by chronic low-grade inflammation, immune imbalance, and frequently associated with compromised respiratory function. During the COVID-19 pandemic, individuals with RTT were classified as high-risk and invited to follow stringent vaccination …

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Unexpectedly competent immune response to SARS-CoV-2 vaccination in Rett syndrome

Ludovica Soldateschi, Silvia Leoncini, Fabio Fiorino, Simone Lucchesi et autres

Rett syndrome (RTT) is a rare neurodevelopmental disorder of genetic origin characterized by chronic low-grade inflammation, immune imbalance, and frequently associated with compromised respiratory function. During the COVID-19 pandemic, individuals with RTT were classified as high-risk and invited to follow stringent vaccination …

Unexpectedly competent immune response to SARS-CoV-2 vaccination in Rett syndrome

Ludovica Soldateschi, Silvia Leoncini, Fabio Fiorino, Simone Lucchesi et autres

Rett syndrome (RTT) is a rare neurodevelopmental disorder of genetic origin characterized by chronic low-grade inflammation, immune imbalance, and frequently associated with compromised respiratory function. During the COVID-19 pandemic, individuals with RTT were classified as high-risk and invited to follow stringent vaccination …

Booster dose reshapes SARS-CoV-2 RBD-specific B cell immunity in people living with HIV

Jacopo Polvere, Simone Lucchesi, Giorgio Montesi, Fabio Fiorino et autres

Long-term persistence of spike-specific memory B cells (MBC) upon mRNA SARS-CoV-2 vaccination remains poorly explored in people living with HIV (PLWH). We previously observed that the primary two-dose immunization elicited a B cell response quantitatively similar but phenotypically different compared to healthy …

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Machine learning approaches to dissect hybrid and vaccine-induced immunity

Giorgio Montesi, Simone Costagli, Simone Lucchesi, Jacopo Polvere et autres

The spread of SARS-CoV-2 Omicron variant and its subvariants, highly transmissible but responsible of milder disease, has increased unreported infection cases. Identifying unaware infected individuals is crucial for estimating the true prevalence of infection and evaluating the breadth of hybrid immunity. In …

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Transcriptomic analysis after SARS-CoV-2 mRNA vaccination reveals a specific gene signature in low-responder hemodialysis patients

Simone Lucchesi, Giorgio Montesi, Jacopo Polvere, Fabio Fiorino et autres

Introduction: Individuals with comorbidities, such as chronic kidney disease and hemodialysis patients (HDP), are particularly susceptible to severe COVID-19 and to its complications. Furthermore, their immune response to vaccines is impaired, requiring tailored vaccination strategies. In this study, we investigated through transcriptomic …

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Longitudinal immunogenicity cohort study of SARS-CoV-2 mRNA vaccines across individuals with different immunocompromising conditions: heterogeneity in the immune response and crucial role of Omicron-adapted booster doses

Annalisa Ciabattini, Elena Pettini, Fabio Fiorino, Jacopo Polvere et autres

BACKGROUND: Individuals with primary and secondary immunodeficiencies, being more susceptible to infections, are a priority for vaccination. Here, we determined and compared in a longitudinal study the immune response elicited by SARS-CoV-2 vaccination across different groups of individuals who are immunocompromised. METHODS: …

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Spike-Specific Memory B Cell Response in Hematopoietic Cell Transplantation Recipients following Multiple mRNA-1273 Vaccinations: A Longitudinal Observational Study

Elena Pettini, Annalisa Ciabattini, Fabio Fiorino, Jacopo Polvere et autres

Preventing SARS-CoV-2 infection is of utmost importance in allogeneic hematopoietic cell transplantation patients (allo-HCT), given their heightened susceptibility to adverse outcomes associated with SARS-CoV-2 infection. However, limited data are available regarding the immune response to COVID-19 vaccines in these subjects, particularly concerning …

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Homologous or heterologous administration of mRNA or adenovirus-vectored vaccines show comparable immunogenicity and effectiveness against the SARS-CoV-2 Omicron variant

G Pastore, Jacopo Polvere, Fabio Fiorino, Simone Lucchesi et autres

BACKGROUND: Heterologous prime-boost schedules have been employed in SARS-CoV-2 vaccination, yet additional data on immunogenicity and effectiveness are still needed. RESEARCH DESIGN AND METHODS: Here, we measured the immunogenicity and effectiveness in the real-world setting of the mRNA booster dose in 181 …

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Longitudinal Immunogenicity Study of SARS-CoV-2 mRNA Vaccines Across Subjects with Different Immunocompromising Conditions: Heterogeneity in the Immune Response and Crucial Role of the Booster Dose

Annalisa Ciabattini, Elena Pettini, Fabio Fiorino, Jacopo Polvere et autres

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Does Nirmatrelvir/Ritonavir Influence the Immune Response against SARS-CoV-2, Independently from Rebound?

Francesca Panza, Fabio Fiorino, G Pastore, Lia Fiaschi et autres

Recurrence of coronavirus disease 19 (COVID-19) symptoms and SARS-CoV-2 viral load relapse have been reported in people treated with nirmatrelvir/ritonavir (NM/r). However, little is understood about the etiology of this phenomenon. Our aim was to investigate the relation between the host’s immune …

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Trajectory of Spike-Specific B Cells Elicited by Two Doses of BNT162b2 mRNA Vaccine

Annalisa Ciabattini, G Pastore, Simone Lucchesi, Giorgio Montesi et autres

The mRNA vaccines for SARS-CoV-2 have demonstrated efficacy and immunogenicity in the real-world setting. However, most of the research on vaccine immunogenicity has been centered on characterizing the antibody response, with limited exploration into the persistence of spike-specific memory B cells. Here …

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