Gernot Sellge

Soluble mucosal addressin cell adhesion molecule 1 is a biomarker for pediatric ulcerative colitis

Moritz Muschaweck, Christian Gutbier, Gernot Sellge, Angeliki Pappa et autres

BACKGROUND: Enhanced expression of mucosal addressin cell adhesion molecule 1 (MAdCAM-1) on high endothelial venules facilitates lymphocyte migration to sites of intestinal inflammation in inflammatory bowel disease (IBD). This process may be accompanied by increased shedding of soluble MAdCAM-1 (sMAdCAM-1) from endothelial …

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Soluble mucosal addressin cell adhesion molecule 1 is a biomarker for pediatric ulcerative colitis

Moritz Muschaweck, Christian Gutbier, Gernot Sellge, Angeliki Pappa et autres

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Bakterielle Fehlbesiedlung des Dünndarms (SIBO) – Therapie, Ernährung, Mikrobiom

Gernot Sellge, Johann Ockenga

SIBO (small intestinal bacterial overgrowth) is defined by bacterial overgrowth or colonization of the small intestine in combination with gastrointestinal symptoms such as bloating, nausea, pain, diarrhoea, malabsorption and food intolerance. SIBO can be caused by various mechanisms such as reduced intestinal …

Bakterielle Fehlbesiedlung des Dünndarms

Gernot Sellge

SIBO (Small Intestinal Bacterial Overgrowth) ist durch eine bakterielle Überwucherung oder Fehlbesiedlung des Dünndarms in Kombination mit intestinalen Symptomen definiert. Intestinale Stase, Hypochlorhydrie, Immundefizienz, Alter u.a. sind auslösende Faktoren. Die Therapie beinhaltet die Behandlung der auslösenden Grunderkrankung, den Ausgleich einer Mangelernährung, den …

Ernährung bei bakterieller Fehlbesiedlung des Dünndarms

Gernot Sellge

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Clinical effectiveness of bidirectional fecal microbiota transfer in the treatment of recurrent Clostridioides difficile infections

Christian Bestfater, Maria J. G. T. Vehreschild, Andreas Stallmach, Kester Tüffers et autres

BACKGROUND: Fecal microbiota transfer (FMT) has become a standard of care in the prevention of multiple recurrent Clostridioides difficile (rCDI) infection. AIM: While primary cure rates range from 70-80% following a single treatment using monodirectional approaches, cure rates of combination treatment remain …

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Fecal Eosinophil Cationic Protein Is a Diagnostic and Predictive Biomarker in Young Adults with Inflammatory Bowel Disease

Nada Abedin, Teresa Seemann, Sandra Kleinfeld, Jessica Ruehrup et autres

BACKGROUND AND AIMS: Fecal biomarkers are important non-invasive markers monitoring disease activity in inflammatory bowel disease (IBD). We compared the significance of fecal eosinophil cationic protein (fECP) and fecal calprotectin (fCal). METHODS: fECP and fCal were measured in patients with Crohn's disease …

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Macrophage-Specific NF-κB Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients

Stamatia Papoutsopoulou, Michael D. Burkitt, François Bergey, Hazel England et autres

The heterogeneous nature of inflammatory bowel disease (IBD) presents challenges, particularly when choosing therapy. Activation of the NF-B transcription factor is a highly regulated, dynamic event in IBD pathogenesis. Using a lentivirus approach, NF-B-regulated luciferase was expressed in patient macrophages, isolated from …

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Eosinophiles cationisches Protein – ein diagnostischer und prädiktiver Biomarker bei jungen Erwachsenen mit chronisch entzündlicher Darmerkrankung

N Abedin, T Langen, S Groner, J Ruehrup et autres

Einleitung: Im Stuhl detektierbare Biomarker sind ein wichtiger Bestandteil für die Diagnose, Beschreibung der Aktivität und Evaluation des Therapieansprechens bei Patienten mit chronisch entzündlichen Darmerkrankungen (CED). Ziele: Ziel der Arbeit war die Definition eines Biomarkers mit vergleichbarer Sensitivität zum Goldstandard Endoskopie und …

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Faecal Micro-RNAs in Inflammatory Bowel Diseases

Julien Verdier, Irene Raphaela Breunig, Margarete Clara Ohse, S. Roubrocks et autres

BACKGROUND AND AIMS: Faecal biomarkers are used as indicators of disease activity in inflammatory bowel diseases [IBD], which include Crohn's disease [CD] and ulcerative colitis [UC]. Micro-RNAs [miRNAs] are small non-coding RNAs detectable in extracellular fluids and can be used as clinical …

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Macrophage-specific NF-κB activation dynamics can segregate inflammatory bowel disease patients

Stamatia Papoutsopoulou, Michael D. Burkitt, François Bergey, Hazel England et autres

Abstract The heterogeneous nature of inflammatory bowel disease (IBD) presents challenges, particularly when choosing therapy. Activation of the NF-κB transcription factor is a highly-regulated, dynamic event in IBD pathogenesis. We expressed the human NF-κB/p65 subunit in blood-derived macrophages, using lentivirus. Confocal imaging …

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Subcellular antigen localization in commensal E. coli is critical for T cell activation and induction of specific tolerance

Eveline Bennek, Ana D. Mandić, Julien Verdier, S. Roubrocks et autres

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