Accès ouvert
2026
dataset
OpenAlex
Kwanho Kim, Zechuan Lin, Sean Simmons, Jacob Parker et autres
This dataset contains raw FASTQ files from the midbrain single-nucleus RNA sequencing (snRNAseq) dataset with hybrid selection for the matching PMDBS samples from the PD5D chort. The same subjects were also profiled with other omics assays including genomic DNAseq, genotyping, single-cell ATACseq, …
us, gb
(code pays fourni par la source)
Accès ouvert
2026
dataset
OpenAlex
Kwanho Kim, Zechuan Lin, Sean Simmons, Jacob Parker et autres
This dataset contains CCS corrected HiFi long-read DNA sequencing (lrDNAseq) in FASTQ format for 100 PMDBS samples from Parkinson's patients and healthy controls. It's part of the PD5D atlas, where the same subjects were also profiled with other omics assays including genotyping, …
us, gb
(code pays fourni par la source)
Accès ouvert
2026
dataset
OpenAlex
Kwanho Kim, Z Ping Lin, Sean Simmons, Jacob Parker et autres
This dataset contains raw FASTQ files from the midbrain single-nucleus RNA sequencing (snRNAseq) dataset with hybrid selection for the matching PMDBS samples from the PD5D chort. The same subjects were also profiled with other omics assays including genomic DNAseq, genotyping, single-cell ATACseq, …
us, gb
(code pays fourni par la source)
Accès ouvert
2026
dataset
OpenAlex
Kwanho Kim, Z Ping Lin, Sean Simmons, Jacob Parker et autres
This dataset contains CCS corrected HiFi long-read DNA sequencing (lrDNAseq) in FASTQ format for 100 PMDBS samples from Parkinson's patients and healthy controls. It's part of the PD5D atlas, where the same subjects were also profiled with other omics assays including genotyping, …
us, gb
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Z Ping Lin, Jacob Parker, Vanitha Nithianandam, Sakthikumar Mathivanan et autres
Synucleinopathies affect ~15 million people and are classically divided into neuronal (Parkinson's disease (PD), dementia with Lewy bodies) and glial (multiple system atrophy) disorders. Here we challenge this dichotomy. We functionally fine-map 90 PD GWAS signals across nine cell types in cortex …
us, cn
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Sean Simmons, Xian Adiconis, Nathan Haywood, Jacob J. Parker et autres
Single-cell RNA-seq (scRNA-seq) is emerging as a powerful tool for understanding gene function across diverse cells. Recently, this has included the use of allele-specific expression (ASE) analysis to better understand how variation in the human genome affects RNA expression at the single-cell …
us
(code pays fourni par la source)
Accès ouvert
2026
dataset
OpenAlex
Sean K. Simmons, Xian Adiconis, Nathan Haywood, Jacob Parker et autres
Additional file 5: Table S4. Allelic imbalance results for PD data with and without selection.
us
(code pays fourni par la source)
Accès ouvert
2026
dataset
OpenAlex
Sean K. Simmons, Xian Adiconis, Nathan Haywood, Jacob Parker et autres
Additional file 8: Table S7. Annotated Sierra peaks for PD and GTEx data.
us
(code pays fourni par la source)
Accès ouvert
2026
dataset
OpenAlex
Sean K. Simmons, Xian Adiconis, Nathan Haywood, Jacob Parker et autres
Additional file 6: Table S5. Selected genes in PD and GTEx data with gene-level QC metrics.
us
(code pays fourni par la source)
Accès ouvert
2026
dataset
OpenAlex
Sean K. Simmons, Xian Adiconis, Nathan Haywood, Jacob Parker et autres
Additional file 3: Table S2. Peak- and gene-level allelic imbalance results with GTEx data.
us
(code pays fourni par la source)
Accès ouvert
2026
dataset
OpenAlex
Sean K. Simmons, Xian Adiconis, Nathan Haywood, Jacob Parker et autres
Additional file 8: Table S7. Annotated Sierra peaks for PD and GTEx data.
us
(code pays fourni par la source)
Accès ouvert
2026
dataset
OpenAlex
Sean K. Simmons, Xian Adiconis, Nathan Haywood, Jacob Parker et autres
Additional file 9: Table S8. Key Resource Table.
us
(code pays fourni par la source)