Sien Zhang

Microbiome dynamics and early microbial signatures predict bone regeneration in marsupialized jaw lesions: a longitudinal 16S sequencing cohort study

Bin Zeng, Mailikanmuhan Maitikuerban, Le Chen, Di-kan Wang et autres

Background Marsupialization is a conservative treatment for odontogenic jaw lesions but is hampered by protracted, unpredictable bone regeneration, lacking early biomarkers. Furthermore, whether these intraosseous lesions harbour a unique microbiome remains unknown. We aimed to characterize microbial dynamics during treatment and develop …

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Single-cell identification of an endothelial cell proximal SPP1+ macrophage population defines the metastatic vascular niche in lymph nodes

Zhentao Lao, Rukeng Tan, Mailikanmuhan Maitikuerban, Xiaofang Xu et autres

Head and neck squamous cell carcinoma (HNSCC) is a highly prevalent malignancy with poor prognosis, largely driven by lymph node metastasis (LNM). Despite its clinical significance, the underlying mechanisms of LNM remain elusive. In this study, we used single-cell transcriptomic data to …

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Clinical correlation and survival analysis of hepatitis B virus infection in oral squamous cell carcinoma: a retrospective study of 1373 patients

Rukeng Tan, Yiyao Zhu, Zengyu Chen, Xinkai Feng et autres

BACKGROUND: Chronic hepatitis B virus (HBV) infection poses a significant global public health challenge and is found closely related to extrahepatic cancers, including head and neck cancer. Oral squamous cell carcinoma (OSCC) is the major category of head and neck cancer. This …

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Asymmetry of the alveolar ridge in Class II maxillary defects reconstructed by an osseo-myocutaneous flap: A CBCT evaluation

Lijia Yang, Sien Zhang, Guangsen Zheng, Guiqing Liao et autres

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Diagnosis of lymph node metastasis in oral squamous cell carcinoma by an MRI-based deep learning model

Le Yang, Sien Zhang, Jinsong Li, Chongjin Feng et autres

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Author response for "Development and Validation of Machine Learning Models for Predicting Tumor Progression in OSCC "

Xueying Mei, Wenhao Luo, Wan Duan, Zhu-Ming Guo et autres

cGAS-ISG15-RAGE axis reprogram necroptotic microenvironment and promote lymphatic metastasis in head and neck cancer

Jingyuan Li, Jun Tan, Tao Wang, Shan Yu et autres

BACKGROUND: Cancer cells frequently evolve necroptotic resistance to overcome various survival stress during tumorigenesis. However, we have previously showed that necroptosis is widespread in head and neck squamous cell carcinoma (HNSCC) and contributes to tumor progression and poor survival via DAMPs-induced migration …

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Contralateral facial artery myomucosal island flap for the reconstruction of T2-T3 oncologic oral defects

Min Huang, Peiyao Li, Le Yang, Yudong Xiao et autres

Objectives To avoid the oncologic risks of ipsilateral regional flaps, this study aimed to explore the feasibility and clinical outcomes of the contralateral-based facial artery myomucosal island flap (C-FAMMIF) for oral T2–T3 oncologic defects reconstruction. Methods A study of flap anatomy was …

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Understanding the multi-functionality and tissue-specificity of decellularized dental pulp matrix hydrogels for endodontic regeneration

Zelin Liang, Junda Li, Hongkun Lin, Sien Zhang et autres

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Functional and esthetic reconstruction of composite lower lip defects with a motor-innervated chimeric facial artery buccinator myomucosal-submental island flap

Peiyao Li, Fan Liu, Zhi Lin, Min Huang et autres

OBJECTIVE: This study aimed to assess the functional and esthetic outcomes of a chimeric innervated buccinator myomucosal-submental island flap (BMM-SIF) for large composite lower lip reconstruction. METHODS: This retrospective study included five patients who underwent lower lip tumor resection and BMM-SIF reconstruction …

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Clinical application of a three-dimensional-printed model in the treatment of intracranial and extracranial communicating tumors: a pilot study

Xiangheng Zhang, Jiahao Li, Zhenqiang He, Dikan Wang et autres

BACKGROUND: Surgical management for intracranial and extracranial communicating tumors is difficult due to the complex anatomical structures. Therefore, assisting methods are urgently needed. Accordingly, this study aimed to investigate the utility of a three-dimensional (3D)-printed model in the treatment of intracranial and …

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Favorable effects of open surgery on patients with extensive skull base osteoradionecrosis through a personalized sequential approach: A case series

Jingyuan Li, Sien Zhang, Daiqiao Ouyang, Lijuan Zeng et autres

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