Jiayi Dai

Prognostic value of cardiopulmonary exercise testing in connective tissue disease-associated pulmonary arterial hypertension at low and intermediate-low risk

Yixin Zhang, Linwei Shan, Jiayi Dai, Zhangdi Zhou et autres

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Identification of immune-related genes and serum miR-100-5p in idiopathic inflammatory myopathy-related heart failure by integrated bioinformatics analysis and clinical validation

Yinghong Tang, Li Ma, Shuang Zhang, Jiayi Dai et autres

OBJECTIVE: Idiopathic inflammatory myopathy (IIM) is a collection of autoimmune disorders marked by muscle inflammation, with heart failure (HF) being a common and deadly complication. Exploring the underlying mechanisms and diagnostic markers for HF in IIM has significant clinical value. METHODS: We …

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TAPSE/PASP combined with IVC can identify poor prognosis in PAH patients with low and intermediate risk

Wei Qian, Yue Zhang, Jiayi Dai, Linwei Shan et autres

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Clinical features and prognosis of idiopathic inflammatory myopathy complicated by heart failure with preserved ejection fraction

Qi Hu, Dongyu Li, Yinghong Tang, Xiaoxuan Sun et autres

OBJECTIVES: Idiopathic inflammatory myopathy (IIM) is increasingly recognized as a systemic disorder with frequent subclinical myocardial involvement. However, its coexistence with heart failure with preserved ejection fraction (HFpEF) remains poorly understood. This study aimed to comprehensively characterize the clinical, serological and radiological …

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Reevaluating risk assessment in connective tissue disease-associated pulmonary arterial hypertension: The prognostic superiority of stroke volume index

Qingqing Cai, Huangshu Ye, Yixin Zhang, Jiayi Dai et autres

Objective: To evaluate the prognostic value of stroke volume index (SVI) compared to cardiac index (CI) in risk stratification and outcome prediction in connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH). Methods: We performed a retrospective analysis of patients diagnosed with CTD-PAH through …

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Using serum cTnT/CK combined with anti-Ro52 antibodies to screen for myocardial involvement and assess prognosis in idiopathic inflammatory myopathy

Yinghong Tang, Dongyu Li, Wangyan Liu, Yue Zhang et autres

OBJECTIVES: To identify risk factors for myocardial involvement in idiopathic inflammatory myopathy (IIM) and evaluate their prognostic value. METHODS: We analysed 92 IIM patients with abnormal cardiac troponin T (cTnT). Myocardial involvement was diagnosed by late gadolinium enhancement on cardiovascular magnetic resonance. …

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Role of B vitamins in modulating homocysteine and metabolic pathways linked to brain atrophy: Metabolomics insights from the VITACOG trial

Tereza Kačerová, Abi G. Yates, Jiayi Dai, Dawn Shepherd et autres

INTRODUCTION: Elevated total homocysteine (tHcy) is a major predictor of brain atrophy, cognitive decline, and Alzheimer's disease (AD) progression. The VITACOG trial, a randomized, placebo-controlled study in mild cognitive impairment (MCI), previously showed that B vitamin supplementation lowered tHcy, slowing brain atrophy …

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The prognostic value of HFA-PEFF score in connective tissue disease-associated PAH: evidence from a cohort study

Jiayi Dai, Li Ma, Yixin Zhang, Linwei Shan et autres

BACKGROUND: Connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH) patients with left heart dysfunction may have worse prognosis. This study was to investigate the prognostic value of HFA-PEFF score in connective tissue disease-associated PAH. METHODS: This single-center retrospective cohort study enrolled 147 CTD-PAH …

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Cardiac MRI optimizes risk stratification accuracy in connective tissue disease-associated pulmonary arterial hypertension: a retrospective cohort study

Xiaohui Wang, Xiaoxuan Sun, Zhangdi Zhou, Dongyu Li et autres

OBJECTIVES: The primary objective of this study is to investigate the potential of cardiac magnetic resonance (CMR) parameters to augment prognostic evaluation in patients with CTD-associated pulmonary arterial hypertension (CTD-PAH). METHODS: A retrospective, single-centre cohort study was conducted on 110 patients with …

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Fragmented QRS complex could predict all-cause mortality in patients with connective tissue disease–associated pulmonary arterial hypertension

Jiayi Dai, Ting Liu, Hang Zhang, Xiaoxuan Sun et autres

OBJECTIVES: To investigate the prognostic impact and pathophysiological characteristics of fragmented QRS complex (fQRS) on patients with CTD-associated pulmonary arterial hypertension (CTD-PAH). METHODS: This was a multicentre retrospective study recruiting 141 patients with CTD-PAH diagnosed by right heart catheterization (114 cases in …

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Using Serum Ctnt/Ck Combined with Anti-Ro52 Antibodies to Screen for Myocardial Involvement and Assess Prognosis in Idiopathic Inflammatory Myopathy

Yinghong Tang, Dongyu Li, Wangyan Liu, Yue Zhang et autres

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Identification of key biomarkers associated with immune cells infiltration for myocardial injury in dermatomyositis by integrated bioinformatics analysis

Yue Zhang, Linwei Shan, Dongyu Li, Yinghong Tang et autres

BACKGROUND: Dermatomyositis (DM) is an acquired autoimmune disease that can cause damage to various organs, including the heart muscle. However, the mechanisms underlying myocardial injury in DM are not yet fully understood. METHODS: In this study, we utilized publicly available datasets from …

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