Xi-Qiu Xu

Targeting viral suppressor of RNAi confers anti-coronaviral activity

Jiyao Chen, Jingfang Mu, Kangping Zhou, Yuming Zhang et autres

Infections caused by coronaviruses are persistent threats to human health in recent decades, necessitating the development of innovative anti-coronaviral therapies. RNA interference (RNAi) is a conserved cell-intrinsic antiviral mechanism in diverse eukaryotic organisms, including mammals. To counteract, many viruses encode viral suppressors …

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Cytosolic DNA sensors activation of human astrocytes inhibits herpes simplex virus through IRF1 induction

Yu Liu, Xi-Qiu Xu, Weijing Li, Biao Zhang et autres

Introduction: While astrocytes participate in the CNS innate immunity against herpes simplex virus type 1 (HSV-1) infection, they are the major target for the virus. Therefore, it is of importance to understand the interplay between the astrocyte-mediated immunity and HSV-1 infection. Methods: …

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Herpes Simplex Virus 1-Induced Ferroptosis Contributes to Viral Encephalitis

Xi-Qiu Xu, Tongran Xu, Wenting Ji, Chong Wang et autres

plays an important role in HSV-1-caused inflammation and encephalitis. Importantly, the inhibition of ferroptosis by either a ferroptosis inhibitor or a proteasome inhibitor to suppress HSV-1-induced Nrf2 degradation effectively alleviates HSV-1-caused neuro-damage and inflammation in infected mice. Overall, our findings uncover the …

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RIG-I contributes to dsDNA-induced innate immune activation in human brain microvascular endothelial cells

Zicheng Huang, Xi-Qiu Xu, Jiapeng Li, Lixing Gu et autres

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CD4+ T cell depletion does not affect the level of viremia in chronically SHIVSF162P3N-infected Chinese cynomolgus monkeys

Hang Liu, Jinbiao Liu, Fengzhen Meng, Xi-Qiu Xu et autres

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Poly(dA:dT) Suppresses HSV-2 Infection of Human Cervical Epithelial Cells Through RIG-I Activation

Dandan Shao, Fengzhen Meng, Yu Liu, Xi-Qiu Xu et autres

Epithelial cells of the female reproductive tract (FRT) participate in the initial innate immunity against viral infections. Poly(dA:dT) is a synthetic analog of B form double-stranded (ds) DNA which can activate the interferon (IFN) signaling pathway-mediated antiviral immunity through DNA-dependent RNA Polymerase …

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Exosomes Transport Anti-Human Immunodeficiency Virus Factors from Human Cervical Epithelial Cells to Macrophages

Xi-Qiu Xu, Biao Zhang, Le Guo, Yu Liu et autres

The female reproductive tract (FRT) is a major site of HIV sexual transmission. As the outermost layer of cells in the FRT, the human cervical epithelial cells (HCEs) have direct contact with HIV or infected cells. Our early work showed that supernatant …

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CD4+ T Cell Depletion Does Not Affect the Level of Viremia in Chronically SHIVSF162P3N-Infected Chinese Cynomolgus Monkeys

Hang Liu, Jin‐Biao Liu, Fengzhen Meng, Xi-Qiu Xu et autres

Abstract Background: Peripheral blood CD4+ T cell counts are a clinical marker for assessing disease progression in HIV-infected patients as well as in SIV-/SHIV–infected macaques. However, it is clinically debatable about whether this marker is a sole indicator for assessing HIV disease …

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Isolation and characterization of spontaneously immortalized B‐lymphocyte lines from HIV‐infected patients with and without non‐Hodgkin's Lymphoma

Ke Zhuang, Yongxi Zhang, Li Zhou, Xiaoying Qi et autres

Abstract Isolation of viable circulating tumor cells (CTC) holds the promise for improving screening, early diagnosis, and personalized treatment of lymphoma. In this study, we isolated and characterized spontaneously immortalized B‐lymphocyte (SIBC) lines from HIV‐infected patients with and without Non‐Hodgkin's Lymphoma (AIDS‐NHL). …

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IL-22 suppresses HSV-2 replication in human cervical epithelial cells

Xi-Qiu Xu, Yu Liu, Biao Zhang, Hang Liu et autres

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The significance of spontaneously immortalized B lymphocytes from patients with AIDS-related non-Hodgkin’s lymphoma and HIV-infected individuals

Ke Zhuang, Yongxi Zhang, Li Zhou, Xiaoying Qi et autres

Abstract Reliable tumor biomarkers for risk assessment, screening, detection, diagnosis, and prognosis remain an unmet need for patients with AIDS-Related Non-Hodgkin’s Lymphoma (AIDS-NHL) and its high risk population–HIV/AIDS patients. In this study, we generated spontaneously immortalized B lymphocyte cell (SIBC) lines by …

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TLR3 Activation of Hepatic Stellate Cell Line Suppresses HBV Replication in HepG2 Cells

Biao Zhang, Yu Liu, Xu Wang, Jieliang Li et autres

There is limited information about the role of hepatic stellate cells (HSCs) in the liver innate immunity against hepatitis B virus (HBV) infection. We thus examined whether hepatic stellate cell line (LX-2) can be immunologically activated and produce antiviral factors that inhibit …

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