Margareth Lara Capurro

Synergistic role of CSPBP and SGS1 in sporozoite entry into Aedes aegypti salivary glands

Alec Morvay, Helena R. C. Araújo, Margareth Lara Capurro, Bianca C. Burini

Vector-borne diseases, particularly malaria, continue to pose a major global health challenge, underscoring the urgent need for innovative and sustainable vector control strategies. Among emerging solutions, genetic control holds great promise for interrupting disease transmission at its source. Malaria transmission relies on …

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Synergistic Role of CSPBP and SGS1 in Sporozoite Entry into Aedes aegypti Salivary Glands

Alec Morvay, Helena R. C. Araújo, Margareth Lara Capurro, Bianca Burini Kojin

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Transgene-induced cell death following dengue-2 virus infection in Aedes aegypti

Danilo O. Carvalho, André Luis Costa‐da‐Silva, Vivian Petersen, Micael Santana de Souza et autres

Dengue viruses (DENVs) are mosquito-borne flaviviruses causing millions of human infections each year and pose a challenge for public health systems worldwide. Aedes aegypti is the principal vector species transmitting DENVs to humans. Controlling Ae. aegypti is difficult due to the abundance …

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Transcriptome profiling and Calreticulin expression in Zika virus -infected Aedes aegypti

Laísa Silva de Almeida, Milton Yutaka Nishiyama, Aurélio Pedroso, André Luis Costa‐da‐Silva et autres

Zika virus (ZIKV) may cause febrile illness and neurological damage, such as microcephaly in fetuses. ZIKV is transmitted to humans by Aedes aegypti, a nearly cosmopolitan mosquito. Understanding the virus-vector molecular interactions has been promising to enhance the knowledge towards disease mitigation. …

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Hemorrhagic fever viruses: Pathogenesis, therapeutics, and emerging and re-emerging potential

Lizdany Flórez‐Álvarez, Edmárcia Elisa de Souza, Viviane Fongaro Botosso, Danielle Bruna Leal Oliveira et autres

Hemorrhagic fever viruses (HFVs) pose a threat to global public health owing to the emergence and re-emergence of highly fatal diseases. Viral hemorrhagic fevers (VHFs) caused by these viruses are mostly characterized by an acute febrile syndrome with coagulation abnormalities and generalized …

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Estudo da dinâmica evolutiva do mosquito Aedes aegypti sob controle SIT e estratégia de replacement

Evelyn Braga, Leonardo Kanashiro, Bruno Ferrari, Luiz Leduíno de Salles Neto et autres

Neste trabalho foram feitas simulações da introdução de dois grupos de mosquitos Aedes aegypti transgênicos em uma região ao longo do tempo - um grupo de inseto estéril (SIT - Sterile Insect Technique) e um grupo que carrega uma alteração no DNA …

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Aedes aegypti mosquito saliva ameliorates acetaminophen-induced liver injury in mice

Josiane Betim de Assis, Bruno Cogliati, Eliane Esteves, Margareth Lara Capurro et autres

Acetaminophen (N-acetyl-p-aminophenol, APAP) overdose is the most common cause of drug-induced liver injury (DILI). Although the primary hepatic damage is induced by APAP-derived toxic intermediates resulting from cytochrome P450 metabolism, immune components also play an important role in DILI pathophysiology. Aedes aegypti …

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Aedes aegypti Control Programmes in Brazil

D. O. Carvalho, Margareth Lara Capurro

Mosquito-borne diseases are among the most significant challenges facing societies around the world. In Brazil, current official epidemiological reports show increasing numbers of cases of mosquito-borne diseases, such as chikungunya, dengue, yellow fever and Zika, which are spreading to new areas of …

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Aedes aegypti SGS1 is critical for Plasmodium gallinaceum infection of both the mosquito midgut and salivary glands

Bianca Burini Kojin, Inés Martín-Martín, Brian Bonilla, Alvaro Molina-Cruz et autres

BACKGROUND: The invasion of the mosquito salivary glands by Plasmodium sporozoites is a critical step that defines the success of malaria transmission and a detailed understanding of the molecules responsible for salivary gland invasion could be leveraged towards control of vector-borne pathogens. …

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Assis et al., PLoS One 2021 dataset

Josiane Betim de Assis, Bruno Cogliati, Eliane Esteves, Margareth Lara Capurro et autres

Dataset from Josiane et al., PLoS One, 2021

Additional file 2 of Aedes aegypti SGS1 is critical for Plasmodium gallinaceum infection of both the mosquito midgut and salivary glands

Bianca Burini Kojin, Inés Martín-Martín, Brian Bonilla, Alvaro Molina-Cruz et autres

Additional file 2: Proteomic analyses of salivary glands extract of LVP and SGS1KO mosquitos

A Metagenomic Approach Identified a Novel Phasi Charoen-Like Virus Coinfecting a Chikungunya Virus-Infected Aedes aegypti Mosquito in Brazil

Marielton dos Passos Cunha, Rafaella Sayuri Ioshino, André Luis Costa‐da‐Silva, Vivian Petersen et autres

Insect-specific viruses do not replicate in vertebrates. Here, we report the genome sequence of a novel strain of a Phasi Charoen-like virus (PCLV) that was isolated from a wild Aedes aegypti mosquito collected in Aracajú, Sergipe State, Brazil. The coding-complete genome of …

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